Tags

Type your tag names separated by a space and hit enter

Herbal therapy for treating rheumatoid arthritis.
Cochrane Database Syst Rev 2001; (1):CD002948CD

Abstract

BACKGROUND

The increasing popularity of the use of complementary and alternative interventions or treatments appears to be particularly evident amongst people with chronic disease. In the treatment of rheumatoid arthritis, one therapy that has been identified as having potential benefit, is herbal medicine (phytotherapy).

OBJECTIVES

To assess the effectiveness of herbal therapies in the treatment of rheumatoid arthritis.

SEARCH STRATEGY

We developed a search strategy using terms to include all forms of arthritis combined with herbal medicine. We searched the following electronic databases from 1966 to 2000: MEDLINE, EMBASE, CISCOM, AMED, CINAHL, Cochrane Controlled Trials Register (CCTR), Cochrane Musculoskeletal specialized register, Dissertation Abstracts, BIDS ISI and the Cochrane Complementary Medicine Fields Specialized Register. This was supplemented by searching the reference lists from retrieved trials.

SELECTION CRITERIA

All randomized trials of herbal interventions in rheumatoid arthritis, compared to placebo. Two reviewers independently read and selected each potential study according to the criteria published in an a priori protocol. Papers of any language were included.

DATA COLLECTION AND ANALYSIS

Data were extracted independently by the same two reviewers and an assessment of methodological quality was conducted.

MAIN RESULTS

Eleven studies met the inclusion criteria. Seven of the studies compared gamma-linolenic acid (GLA) to placebo although three of these were not suitable for data pooling. The remaining studies considered four different herbal interventions and were assessed individually. All of the GLA studies found some improvement in clinical outcomes but methodology and study quality was variable, making it difficult to draw conclusive results. However, the better quality studies suggest potential relief of pain, morning stiffness and joint tenderness. With the exception of one intervention (Tripterygium wilfordii hook F), no serious side effects were reported.

REVIEWER'S CONCLUSIONS

There appears to be some potential benefit for the use of GLA in rheumatoid arthritis although further studies are required to establish optimum dosage and duration of treatment. The single studies are inconclusive.

Authors+Show Affiliations

Institute of Health & Community Studies, Bournemouth University, Bournemouth House, Bournemouth University, 17 Christchurch Road, Bournemouth, Dorset, UK, BH1 3LG. clittle@bournemouth.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

11279784

Citation

Little, C, and T Parsons. "Herbal Therapy for Treating Rheumatoid Arthritis." The Cochrane Database of Systematic Reviews, 2001, p. CD002948.
Little C, Parsons T. Herbal therapy for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2001.
Little, C., & Parsons, T. (2001). Herbal therapy for treating rheumatoid arthritis. The Cochrane Database of Systematic Reviews, (1), p. CD002948.
Little C, Parsons T. Herbal Therapy for Treating Rheumatoid Arthritis. Cochrane Database Syst Rev. 2001;(1)CD002948. PubMed PMID: 11279784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herbal therapy for treating rheumatoid arthritis. AU - Little,C, AU - Parsons,T, PY - 2001/5/2/pubmed PY - 2002/1/5/medline PY - 2001/5/2/entrez SP - CD002948 EP - CD002948 JF - The Cochrane database of systematic reviews JO - Cochrane Database Syst Rev IS - 1 N2 - BACKGROUND: The increasing popularity of the use of complementary and alternative interventions or treatments appears to be particularly evident amongst people with chronic disease. In the treatment of rheumatoid arthritis, one therapy that has been identified as having potential benefit, is herbal medicine (phytotherapy). OBJECTIVES: To assess the effectiveness of herbal therapies in the treatment of rheumatoid arthritis. SEARCH STRATEGY: We developed a search strategy using terms to include all forms of arthritis combined with herbal medicine. We searched the following electronic databases from 1966 to 2000: MEDLINE, EMBASE, CISCOM, AMED, CINAHL, Cochrane Controlled Trials Register (CCTR), Cochrane Musculoskeletal specialized register, Dissertation Abstracts, BIDS ISI and the Cochrane Complementary Medicine Fields Specialized Register. This was supplemented by searching the reference lists from retrieved trials. SELECTION CRITERIA: All randomized trials of herbal interventions in rheumatoid arthritis, compared to placebo. Two reviewers independently read and selected each potential study according to the criteria published in an a priori protocol. Papers of any language were included. DATA COLLECTION AND ANALYSIS: Data were extracted independently by the same two reviewers and an assessment of methodological quality was conducted. MAIN RESULTS: Eleven studies met the inclusion criteria. Seven of the studies compared gamma-linolenic acid (GLA) to placebo although three of these were not suitable for data pooling. The remaining studies considered four different herbal interventions and were assessed individually. All of the GLA studies found some improvement in clinical outcomes but methodology and study quality was variable, making it difficult to draw conclusive results. However, the better quality studies suggest potential relief of pain, morning stiffness and joint tenderness. With the exception of one intervention (Tripterygium wilfordii hook F), no serious side effects were reported. REVIEWER'S CONCLUSIONS: There appears to be some potential benefit for the use of GLA in rheumatoid arthritis although further studies are required to establish optimum dosage and duration of treatment. The single studies are inconclusive. SN - 1469-493X UR - https://www.unboundmedicine.com/medline/citation/11279784/full_citation L2 - https://doi.org/10.1002/14651858.CD002948 DB - PRIME DP - Unbound Medicine ER -