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Multiple sclerosis and age at infection with common viruses.
Epidemiology 2001; 12(3):301-6E

Abstract

Increased risk of multiple sclerosis has been reported among individuals with a history of measles and other common childhood diseases during adolescence, infectious mononucleosis, or exposure to the canine distemper virus. We investigated these associations in a case-control study nested within the Nurses' Health Study (121,700 women traced since 1976) and the Nurses' Health Study II (116,671 women traced since 1989). Age at diagnosis of common viral diseases and birth order were obtained through a questionnaire. Our results include 301 cases with multiple sclerosis and their (up to six) matched controls. Except for infectious mononucleosis, which was a moderate risk factor (odds ratio = 2.1, 95% confidence interval = 1.5-2.9), we found little association between history of common viral diseases or exposure to canine distemper virus and risk of multiple sclerosis. We did find a relation between mumps after 15 years of age (odds ratio = 2.3, 95% confidence interval = 1.2-4.3) or measles after age 15 years of age (odds ratio = 2.8, 95% confidence interval = 0.8-9.1) and multiple sclerosis. Birth order was not materially related to multiple sclerosis. Our findings support the hypothesis that individuals who suffered from infectious mononucleosis, a marker of late infection with the Epstein-Barr virus, have an increased risk of multiple sclerosis. Late infection with other common viruses may also be associated with increased risk.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11337603

Citation

Hernán, M A., et al. "Multiple Sclerosis and Age at Infection With Common Viruses." Epidemiology (Cambridge, Mass.), vol. 12, no. 3, 2001, pp. 301-6.
Hernán MA, Zhang SM, Lipworth L, et al. Multiple sclerosis and age at infection with common viruses. Epidemiology. 2001;12(3):301-6.
Hernán, M. A., Zhang, S. M., Lipworth, L., Olek, M. J., & Ascherio, A. (2001). Multiple sclerosis and age at infection with common viruses. Epidemiology (Cambridge, Mass.), 12(3), pp. 301-6.
Hernán MA, et al. Multiple Sclerosis and Age at Infection With Common Viruses. Epidemiology. 2001;12(3):301-6. PubMed PMID: 11337603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple sclerosis and age at infection with common viruses. AU - Hernán,M A, AU - Zhang,S M, AU - Lipworth,L, AU - Olek,M J, AU - Ascherio,A, PY - 2001/5/5/pubmed PY - 2001/9/8/medline PY - 2001/5/5/entrez SP - 301 EP - 6 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 12 IS - 3 N2 - Increased risk of multiple sclerosis has been reported among individuals with a history of measles and other common childhood diseases during adolescence, infectious mononucleosis, or exposure to the canine distemper virus. We investigated these associations in a case-control study nested within the Nurses' Health Study (121,700 women traced since 1976) and the Nurses' Health Study II (116,671 women traced since 1989). Age at diagnosis of common viral diseases and birth order were obtained through a questionnaire. Our results include 301 cases with multiple sclerosis and their (up to six) matched controls. Except for infectious mononucleosis, which was a moderate risk factor (odds ratio = 2.1, 95% confidence interval = 1.5-2.9), we found little association between history of common viral diseases or exposure to canine distemper virus and risk of multiple sclerosis. We did find a relation between mumps after 15 years of age (odds ratio = 2.3, 95% confidence interval = 1.2-4.3) or measles after age 15 years of age (odds ratio = 2.8, 95% confidence interval = 0.8-9.1) and multiple sclerosis. Birth order was not materially related to multiple sclerosis. Our findings support the hypothesis that individuals who suffered from infectious mononucleosis, a marker of late infection with the Epstein-Barr virus, have an increased risk of multiple sclerosis. Late infection with other common viruses may also be associated with increased risk. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/11337603/full_citation L2 - http://dx.doi.org/10.1097/00001648-200105000-00009 DB - PRIME DP - Unbound Medicine ER -