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Multiple sclerosis and age at infection with common viruses.

Abstract

Increased risk of multiple sclerosis has been reported among individuals with a history of measles and other common childhood diseases during adolescence, infectious mononucleosis, or exposure to the canine distemper virus. We investigated these associations in a case-control study nested within the Nurses' Health Study (121,700 women traced since 1976) and the Nurses' Health Study II (116,671 women traced since 1989). Age at diagnosis of common viral diseases and birth order were obtained through a questionnaire. Our results include 301 cases with multiple sclerosis and their (up to six) matched controls. Except for infectious mononucleosis, which was a moderate risk factor (odds ratio = 2.1, 95% confidence interval = 1.5-2.9), we found little association between history of common viral diseases or exposure to canine distemper virus and risk of multiple sclerosis. We did find a relation between mumps after 15 years of age (odds ratio = 2.3, 95% confidence interval = 1.2-4.3) or measles after age 15 years of age (odds ratio = 2.8, 95% confidence interval = 0.8-9.1) and multiple sclerosis. Birth order was not materially related to multiple sclerosis. Our findings support the hypothesis that individuals who suffered from infectious mononucleosis, a marker of late infection with the Epstein-Barr virus, have an increased risk of multiple sclerosis. Late infection with other common viruses may also be associated with increased risk.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

    , , ,

    Source

    Epidemiology (Cambridge, Mass.) 12:3 2001 May pg 301-6

    MeSH

    Adult
    Age of Onset
    Animals
    Birth Order
    Case-Control Studies
    Distemper
    Dogs
    Epstein-Barr Virus Infections
    Female
    Humans
    Infectious Mononucleosis
    Measles
    Multiple Sclerosis
    Odds Ratio
    Risk Factors
    Virus Diseases

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11337603

    Citation

    Hernán, M A., et al. "Multiple Sclerosis and Age at Infection With Common Viruses." Epidemiology (Cambridge, Mass.), vol. 12, no. 3, 2001, pp. 301-6.
    Hernán MA, Zhang SM, Lipworth L, et al. Multiple sclerosis and age at infection with common viruses. Epidemiology. 2001;12(3):301-6.
    Hernán, M. A., Zhang, S. M., Lipworth, L., Olek, M. J., & Ascherio, A. (2001). Multiple sclerosis and age at infection with common viruses. Epidemiology (Cambridge, Mass.), 12(3), pp. 301-6.
    Hernán MA, et al. Multiple Sclerosis and Age at Infection With Common Viruses. Epidemiology. 2001;12(3):301-6. PubMed PMID: 11337603.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Multiple sclerosis and age at infection with common viruses. AU - Hernán,M A, AU - Zhang,S M, AU - Lipworth,L, AU - Olek,M J, AU - Ascherio,A, PY - 2001/5/5/pubmed PY - 2001/9/8/medline PY - 2001/5/5/entrez SP - 301 EP - 6 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 12 IS - 3 N2 - Increased risk of multiple sclerosis has been reported among individuals with a history of measles and other common childhood diseases during adolescence, infectious mononucleosis, or exposure to the canine distemper virus. We investigated these associations in a case-control study nested within the Nurses' Health Study (121,700 women traced since 1976) and the Nurses' Health Study II (116,671 women traced since 1989). Age at diagnosis of common viral diseases and birth order were obtained through a questionnaire. Our results include 301 cases with multiple sclerosis and their (up to six) matched controls. Except for infectious mononucleosis, which was a moderate risk factor (odds ratio = 2.1, 95% confidence interval = 1.5-2.9), we found little association between history of common viral diseases or exposure to canine distemper virus and risk of multiple sclerosis. We did find a relation between mumps after 15 years of age (odds ratio = 2.3, 95% confidence interval = 1.2-4.3) or measles after age 15 years of age (odds ratio = 2.8, 95% confidence interval = 0.8-9.1) and multiple sclerosis. Birth order was not materially related to multiple sclerosis. Our findings support the hypothesis that individuals who suffered from infectious mononucleosis, a marker of late infection with the Epstein-Barr virus, have an increased risk of multiple sclerosis. Late infection with other common viruses may also be associated with increased risk. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/11337603/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=11337603 DB - PRIME DP - Unbound Medicine ER -