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Clinical staging of chronic lymphocytic leukemia.
Blood 1975; 46(2):219-34Blood

Abstract

A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia. Analysis of 125 patients. in the present series showed the following median survival times (in months) from diagnosis: stage 0, is greater than 150; stage I 101; stage II, 71; stage III, 19; stage IV, 19, The median survival for the entire series was 71 mo. The prognostic significance of the stage remained even after adjustment was made for age and sex. However, both sex and age were shown to be poor predictors of survival after adjustment for stage. The method of staging proved to be a reliable predictor of survival whether used at diagnosis or during the course of the disease. The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1139039

Citation

Rai, K R., et al. "Clinical Staging of Chronic Lymphocytic Leukemia." Blood, vol. 46, no. 2, 1975, pp. 219-34.
Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46(2):219-34.
Rai, K. R., Sawitsky, A., Cronkite, E. P., Chanana, A. D., Levy, R. N., & Pasternack, B. S. (1975). Clinical staging of chronic lymphocytic leukemia. Blood, 46(2), pp. 219-34.
Rai KR, et al. Clinical Staging of Chronic Lymphocytic Leukemia. Blood. 1975;46(2):219-34. PubMed PMID: 1139039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical staging of chronic lymphocytic leukemia. AU - Rai,K R, AU - Sawitsky,A, AU - Cronkite,E P, AU - Chanana,A D, AU - Levy,R N, AU - Pasternack,B S, PY - 1975/8/1/pubmed PY - 1975/8/1/medline PY - 1975/8/1/entrez SP - 219 EP - 34 JF - Blood JO - Blood VL - 46 IS - 2 N2 - A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia. Analysis of 125 patients. in the present series showed the following median survival times (in months) from diagnosis: stage 0, is greater than 150; stage I 101; stage II, 71; stage III, 19; stage IV, 19, The median survival for the entire series was 71 mo. The prognostic significance of the stage remained even after adjustment was made for age and sex. However, both sex and age were shown to be poor predictors of survival after adjustment for stage. The method of staging proved to be a reliable predictor of survival whether used at diagnosis or during the course of the disease. The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/1139039/full_citation L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=1139039 DB - PRIME DP - Unbound Medicine ER -