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A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps.

Abstract

BACKGROUND

Muscle cramps that improve after carnitine or vitamin E therapies are common in haemodialysis (HD) patients. Because vitamin C participates in carnitine biosynthesis, and its levels are reduced in uraemia, subclinical vitamin C depletion may contribute to HD cramps. Our aim was to determine the effects of vitamins C, E and their combination on the frequency and intensity of HD cramps.

METHODS

In this placebo-controlled, double-blind study, 60 HD-patients were randomized into four therapeutic groups. Each group (n=15) received six identical capsules daily for 8 weeks, containing one of the following: vitamin E (400 mg), vitamin C (250 mg), their combination, or placebo.

RESULTS

The frequency and intensity of HD cramps decreased significantly in all three vitamin groups compared with the placebo group at the end of the trial, and compared with the pre-treatment values. At the end of the trial, vitamins E, C, their combination, and placebo produced cramp reductions of 54, 61, 97 and 7%, respectively. The percentage cramp reduction had no significant correlation with age, sex, aetiology of end-stage renal disease, serum electrolytes or HD duration, but showed a positive correlation (r=0.33, P=0.01) with the type of therapy. No vitamin-related adverse effects were encountered during the trial.

CONCLUSION

Short-term treatment with the combination of vitamins E and C is safe and effective in reducing HD cramps; however, its safety for prolonged therapy has yet to be evaluated in HD patients.

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  • Authors+Show Affiliations

    ,

    Division of Nephrology, Department of Internal Medicine, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

    , ,

    Source

    MeSH

    Ascorbic Acid
    Dietary Supplements
    Double-Blind Method
    Drug Therapy, Combination
    Electrolytes
    Female
    Hematocrit
    Humans
    Kidney Failure, Chronic
    Male
    Middle Aged
    Muscle Cramp
    Placebos
    Renal Dialysis
    Vitamin E

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    11427639

    Citation

    Khajehdehi, P, et al. "A Randomized, Double-blind, Placebo-controlled Trial of Supplementary Vitamins E, C and Their Combination for Treatment of Haemodialysis Cramps." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 16, no. 7, 2001, pp. 1448-51.
    Khajehdehi P, Mojerlou M, Behzadi S, et al. A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. Nephrol Dial Transplant. 2001;16(7):1448-51.
    Khajehdehi, P., Mojerlou, M., Behzadi, S., & Rais-Jalali, G. A. (2001). A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 16(7), pp. 1448-51.
    Khajehdehi P, et al. A Randomized, Double-blind, Placebo-controlled Trial of Supplementary Vitamins E, C and Their Combination for Treatment of Haemodialysis Cramps. Nephrol Dial Transplant. 2001;16(7):1448-51. PubMed PMID: 11427639.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. AU - Khajehdehi,P, AU - Mojerlou,M, AU - Behzadi,S, AU - Rais-Jalali,G A, PY - 2001/6/28/pubmed PY - 2001/9/28/medline PY - 2001/6/28/entrez SP - 1448 EP - 51 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol. Dial. Transplant. VL - 16 IS - 7 N2 - BACKGROUND: Muscle cramps that improve after carnitine or vitamin E therapies are common in haemodialysis (HD) patients. Because vitamin C participates in carnitine biosynthesis, and its levels are reduced in uraemia, subclinical vitamin C depletion may contribute to HD cramps. Our aim was to determine the effects of vitamins C, E and their combination on the frequency and intensity of HD cramps. METHODS: In this placebo-controlled, double-blind study, 60 HD-patients were randomized into four therapeutic groups. Each group (n=15) received six identical capsules daily for 8 weeks, containing one of the following: vitamin E (400 mg), vitamin C (250 mg), their combination, or placebo. RESULTS: The frequency and intensity of HD cramps decreased significantly in all three vitamin groups compared with the placebo group at the end of the trial, and compared with the pre-treatment values. At the end of the trial, vitamins E, C, their combination, and placebo produced cramp reductions of 54, 61, 97 and 7%, respectively. The percentage cramp reduction had no significant correlation with age, sex, aetiology of end-stage renal disease, serum electrolytes or HD duration, but showed a positive correlation (r=0.33, P=0.01) with the type of therapy. No vitamin-related adverse effects were encountered during the trial. CONCLUSION: Short-term treatment with the combination of vitamins E and C is safe and effective in reducing HD cramps; however, its safety for prolonged therapy has yet to be evaluated in HD patients. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/11427639/full_citation L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/16.7.1448 DB - PRIME DP - Unbound Medicine ER -