Tags

Type your tag names separated by a space and hit enter

Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study.

Abstract

A number of epidemiological studies have shown an association between beta-carotene and the risk of cardiovascular diseases, whereas only a few studies are available concerning the association of lycopene with the risk of coronary events, and no studies have been undertaken concerning lycopene and stroke. Thus, we tested the hypothesis that low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke. The subjects were 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Forty-one men had either a fatal or a non-fatal acute coronary event or a stroke by December 1997. In a Cox' proportional hazard's model adjusting for examination years, age, systolic blood pressure and three nutritional factors (serum folate, beta-carotene and plasma vitamin C), men in the lowest quarter of serum lycopene levels (< or =0.07 micromol/l) had a 3.3-fold (95 % CI 1.7, 6.4, risk of acute coronary events or stroke compared with the others. Our study suggests that a low serum level of lycopene is associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland.

    , , , , , ,

    Source

    The British journal of nutrition 85:6 2001 Jun pg 749-54

    MeSH

    Adult
    Antioxidants
    Biomarkers
    Carotenoids
    Coronary Disease
    Finland
    Follow-Up Studies
    Humans
    Lycopene
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Stroke

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11430780

    Citation

    Rissanen, T H., et al. "Low Serum Lycopene Concentration Is Associated With an Excess Incidence of Acute Coronary Events and Stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study." The British Journal of Nutrition, vol. 85, no. 6, 2001, pp. 749-54.
    Rissanen TH, Voutilainen S, Nyyssönen K, et al. Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2001;85(6):749-54.
    Rissanen, T. H., Voutilainen, S., Nyyssönen, K., Lakka, T. A., Sivenius, J., Salonen, R., ... Salonen, J. T. (2001). Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. The British Journal of Nutrition, 85(6), pp. 749-54.
    Rissanen TH, et al. Low Serum Lycopene Concentration Is Associated With an Excess Incidence of Acute Coronary Events and Stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2001;85(6):749-54. PubMed PMID: 11430780.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. AU - Rissanen,T H, AU - Voutilainen,S, AU - Nyyssönen,K, AU - Lakka,T A, AU - Sivenius,J, AU - Salonen,R, AU - Kaplan,G A, AU - Salonen,J T, PY - 2001/6/30/pubmed PY - 2001/7/13/medline PY - 2001/6/30/entrez SP - 749 EP - 54 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 85 IS - 6 N2 - A number of epidemiological studies have shown an association between beta-carotene and the risk of cardiovascular diseases, whereas only a few studies are available concerning the association of lycopene with the risk of coronary events, and no studies have been undertaken concerning lycopene and stroke. Thus, we tested the hypothesis that low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke. The subjects were 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Forty-one men had either a fatal or a non-fatal acute coronary event or a stroke by December 1997. In a Cox' proportional hazard's model adjusting for examination years, age, systolic blood pressure and three nutritional factors (serum folate, beta-carotene and plasma vitamin C), men in the lowest quarter of serum lycopene levels (< or =0.07 micromol/l) had a 3.3-fold (95 % CI 1.7, 6.4, risk of acute coronary events or stroke compared with the others. Our study suggests that a low serum level of lycopene is associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11430780/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007114501001271/type/journal_article DB - PRIME DP - Unbound Medicine ER -