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Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Br J Nutr 2001; 85(6):749-54BJ

Abstract

A number of epidemiological studies have shown an association between beta-carotene and the risk of cardiovascular diseases, whereas only a few studies are available concerning the association of lycopene with the risk of coronary events, and no studies have been undertaken concerning lycopene and stroke. Thus, we tested the hypothesis that low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke. The subjects were 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Forty-one men had either a fatal or a non-fatal acute coronary event or a stroke by December 1997. In a Cox' proportional hazard's model adjusting for examination years, age, systolic blood pressure and three nutritional factors (serum folate, beta-carotene and plasma vitamin C), men in the lowest quarter of serum lycopene levels (< or =0.07 micromol/l) had a 3.3-fold (95 % CI 1.7, 6.4, risk of acute coronary events or stroke compared with the others. Our study suggests that a low serum level of lycopene is associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.

Authors+Show Affiliations

Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11430780

Citation

Rissanen, T H., et al. "Low Serum Lycopene Concentration Is Associated With an Excess Incidence of Acute Coronary Events and Stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study." The British Journal of Nutrition, vol. 85, no. 6, 2001, pp. 749-54.
Rissanen TH, Voutilainen S, Nyyssönen K, et al. Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2001;85(6):749-54.
Rissanen, T. H., Voutilainen, S., Nyyssönen, K., Lakka, T. A., Sivenius, J., Salonen, R., ... Salonen, J. T. (2001). Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. The British Journal of Nutrition, 85(6), pp. 749-54.
Rissanen TH, et al. Low Serum Lycopene Concentration Is Associated With an Excess Incidence of Acute Coronary Events and Stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2001;85(6):749-54. PubMed PMID: 11430780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. AU - Rissanen,T H, AU - Voutilainen,S, AU - Nyyssönen,K, AU - Lakka,T A, AU - Sivenius,J, AU - Salonen,R, AU - Kaplan,G A, AU - Salonen,J T, PY - 2001/6/30/pubmed PY - 2001/7/13/medline PY - 2001/6/30/entrez SP - 749 EP - 54 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 85 IS - 6 N2 - A number of epidemiological studies have shown an association between beta-carotene and the risk of cardiovascular diseases, whereas only a few studies are available concerning the association of lycopene with the risk of coronary events, and no studies have been undertaken concerning lycopene and stroke. Thus, we tested the hypothesis that low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke. The subjects were 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study. Forty-one men had either a fatal or a non-fatal acute coronary event or a stroke by December 1997. In a Cox' proportional hazard's model adjusting for examination years, age, systolic blood pressure and three nutritional factors (serum folate, beta-carotene and plasma vitamin C), men in the lowest quarter of serum lycopene levels (< or =0.07 micromol/l) had a 3.3-fold (95 % CI 1.7, 6.4, risk of acute coronary events or stroke compared with the others. Our study suggests that a low serum level of lycopene is associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11430780/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007114501001271/type/journal_article DB - PRIME DP - Unbound Medicine ER -