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Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines.
Scand J Rheumatol 2001; 30(3):129-34SJ

Abstract

The efficacy of weekly low-dose methotrexate treatment of rheumatoid arthritis is well documented. Efficacy and adverse effects are both dose dependent. and adverse effects rather than lack of efficacy are the main reason for discontinuing therapy. Several adverse effects are related to folate deficiencies, largely due to the antifolate properties of methotrexate. In order to reduce adverse effects without compromising drug efficacy, numerous clinical investigations have been performed using supplementation with folic or folinic acid during methotrexate therapy of patients with rheumatoid arthritis, addressing both the timing of folate supplementation and the weekly folate-to-methotrexate ratio. Based on these studies, an individually adjusted supply of folic acid rather than folinic acid is proposed. For many patients, however, a properly balanced diet is sufficient to avoid folate deficiency.

Authors+Show Affiliations

Center for Rheumatic Diseases, The National Hospital, University of Oslo, Norway.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11469521

Citation

Endresen, G K., and G Husby. "Folate Supplementation During Methotrexate Treatment of Patients With Rheumatoid Arthritis. an Update and Proposals for Guidelines." Scandinavian Journal of Rheumatology, vol. 30, no. 3, 2001, pp. 129-34.
Endresen GK, Husby G. Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines. Scand J Rheumatol. 2001;30(3):129-34.
Endresen, G. K., & Husby, G. (2001). Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines. Scandinavian Journal of Rheumatology, 30(3), pp. 129-34.
Endresen GK, Husby G. Folate Supplementation During Methotrexate Treatment of Patients With Rheumatoid Arthritis. an Update and Proposals for Guidelines. Scand J Rheumatol. 2001;30(3):129-34. PubMed PMID: 11469521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines. AU - Endresen,G K, AU - Husby,G, PY - 2001/7/27/pubmed PY - 2001/8/3/medline PY - 2001/7/27/entrez SP - 129 EP - 34 JF - Scandinavian journal of rheumatology JO - Scand. J. Rheumatol. VL - 30 IS - 3 N2 - The efficacy of weekly low-dose methotrexate treatment of rheumatoid arthritis is well documented. Efficacy and adverse effects are both dose dependent. and adverse effects rather than lack of efficacy are the main reason for discontinuing therapy. Several adverse effects are related to folate deficiencies, largely due to the antifolate properties of methotrexate. In order to reduce adverse effects without compromising drug efficacy, numerous clinical investigations have been performed using supplementation with folic or folinic acid during methotrexate therapy of patients with rheumatoid arthritis, addressing both the timing of folate supplementation and the weekly folate-to-methotrexate ratio. Based on these studies, an individually adjusted supply of folic acid rather than folinic acid is proposed. For many patients, however, a properly balanced diet is sufficient to avoid folate deficiency. SN - 0300-9742 UR - http://www.unboundmedicine.com/medline/citation/11469521/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/030097401300162888 DB - PRIME DP - Unbound Medicine ER -