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Symptoms of ovarian cancer.

Abstract

OBJECTIVE

To examine the symptoms of ovarian cancer in patients compared with symptoms experienced by healthy women using a case-control design.

METHODS

Cases (n = 168) were women with ovarian cancer diagnosed at two hospitals in New York between 1994 and 1997 who were interviewed shortly after diagnosis. They were compared with healthy women (n = 251 controls) from the community. Women were asked about the prevalence, duration, and constancy of eight symptoms and about use of three types of medications in the 6 to 12 months before diagnosis (cases) or interview (controls).

RESULTS

Nearly all the cases (93%) reported at least one symptom, compared with 42% of controls. The most common symptoms among cases were: unusual bloating, fullness, and pressure in the abdomen (71%); unusual abdominal pain or lower back pain (52%); and lack of energy (43%). The proportions of controls reporting these symptoms were 9, 15, and 16%, respectively, resulting in odds ratios and 95% confidence intervals of 25.3 (15.6, 40.9), 6.2 (4.0, 9.6), and 3.9 (2.5, 6.1), respectively, for these symptoms. Bloating, fullness, and pressure was of more recent onset among cases than controls (4.9 months compared with 7.6 months, P =.01). There were only minor differences in reported symptoms between cases with early and later stage disease.

CONCLUSION

Unusual bloating, fullness, and pressure, abdominal or back pain, and lack of energy are prominent symptoms in women with ovarian cancer and distinguish them from controls. Information on symptoms may make women and physicians more aware of changes associated with ovarian cancer.

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  • Authors+Show Affiliations

    ,

    Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. olsons@mskcc.org

    , , , ,

    Source

    Obstetrics and gynecology 98:2 2001 Aug pg 212-7

    MeSH

    Adult
    Aged
    Analgesics
    Antidiarrheals
    Case-Control Studies
    Cathartics
    Female
    Humans
    Middle Aged
    Ovarian Neoplasms
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11506835

    Citation

    Olson, S H., et al. "Symptoms of Ovarian Cancer." Obstetrics and Gynecology, vol. 98, no. 2, 2001, pp. 212-7.
    Olson SH, Mignone L, Nakraseive C, et al. Symptoms of ovarian cancer. Obstet Gynecol. 2001;98(2):212-7.
    Olson, S. H., Mignone, L., Nakraseive, C., Caputo, T. A., Barakat, R. R., & Harlap, S. (2001). Symptoms of ovarian cancer. Obstetrics and Gynecology, 98(2), pp. 212-7.
    Olson SH, et al. Symptoms of Ovarian Cancer. Obstet Gynecol. 2001;98(2):212-7. PubMed PMID: 11506835.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Symptoms of ovarian cancer. AU - Olson,S H, AU - Mignone,L, AU - Nakraseive,C, AU - Caputo,T A, AU - Barakat,R R, AU - Harlap,S, PY - 2001/8/17/pubmed PY - 2001/9/8/medline PY - 2001/8/17/entrez SP - 212 EP - 7 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 98 IS - 2 N2 - OBJECTIVE: To examine the symptoms of ovarian cancer in patients compared with symptoms experienced by healthy women using a case-control design. METHODS: Cases (n = 168) were women with ovarian cancer diagnosed at two hospitals in New York between 1994 and 1997 who were interviewed shortly after diagnosis. They were compared with healthy women (n = 251 controls) from the community. Women were asked about the prevalence, duration, and constancy of eight symptoms and about use of three types of medications in the 6 to 12 months before diagnosis (cases) or interview (controls). RESULTS: Nearly all the cases (93%) reported at least one symptom, compared with 42% of controls. The most common symptoms among cases were: unusual bloating, fullness, and pressure in the abdomen (71%); unusual abdominal pain or lower back pain (52%); and lack of energy (43%). The proportions of controls reporting these symptoms were 9, 15, and 16%, respectively, resulting in odds ratios and 95% confidence intervals of 25.3 (15.6, 40.9), 6.2 (4.0, 9.6), and 3.9 (2.5, 6.1), respectively, for these symptoms. Bloating, fullness, and pressure was of more recent onset among cases than controls (4.9 months compared with 7.6 months, P =.01). There were only minor differences in reported symptoms between cases with early and later stage disease. CONCLUSION: Unusual bloating, fullness, and pressure, abdominal or back pain, and lack of energy are prominent symptoms in women with ovarian cancer and distinguish them from controls. Information on symptoms may make women and physicians more aware of changes associated with ovarian cancer. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/11506835/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0029-7844(01)01457-0 DB - PRIME DP - Unbound Medicine ER -