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Clinical features and therapeutic outcomes of 65 patients with acromegaly at Tokyo Women's Medical University.

Abstract

OBJECTIVE

The purpose of this study was to survey the clinical characteristics, complications, and therapeutic outcome in patients with acromegaly.

PATIENTS AND METHODS

The clinical features of 65 patients with acromegaly (31 males, 34 females; mean age: 50+/-2 yr.) who were admitted to Tokyo Women's Medical University between 1990 and 1999 were analyzed retrospectively from medical records.

RESULTS

The retrospective analysis revealed that the diagnosis of acromegaly was preceded by approximately 8.1+/-1.1 years of signs and symptoms of the disease. Forty-six of the 65 patients (71%) had macroadenomas, 16 (25%) had microadenomas, and the remaining three had empty sella. The rate of biochemical cure or remission was 81% for microadenoma (13/16), 64% for macroadenoma without extrasellar extension (9/14), and 13% for macroadenoma with cavernous sinus extension (2/15). Eighteen (28%) patients had impaired glucose tolerance (IGT) and 32 (49%) had diabetes mellitus (DM). After treatment for acromegaly, glucose metabolism was analyzed again in 38 patients, and it improved in 26 patients with IGT or DM. Twenty-five of 65 patients (38%) had hypertension. Of 26 patients who underwent barium enema or colonoscopy, 10 had colonic polyps and 4 had colon cancer.

CONCLUSION

This study suggests that long-term excessive growth hormone (GH) secretion causes many complications. Therefore, awareness of the early symptoms and signs of acromegaly and long-term careful management of complications, along with therapy to reduce serum GH/insulin-like growth factor (IGF)-I levels, are important for patients with acromegaly.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University.

    , , , , ,

    Source

    Internal medicine (Tokyo, Japan) 40:10 2001 Oct pg 987-92

    MeSH

    Acromegaly
    Adult
    Age Distribution
    Aged
    Bromocriptine
    Combined Modality Therapy
    Endocrine Surgical Procedures
    Female
    Hormone Antagonists
    Human Growth Hormone
    Humans
    Insulin-Like Growth Factor I
    Male
    Medical Records
    Middle Aged
    Radiotherapy, Adjuvant
    Retrospective Studies
    Sex Distribution
    Tokyo
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11688841

    Citation

    Fukuda, I, et al. "Clinical Features and Therapeutic Outcomes of 65 Patients With Acromegaly at Tokyo Women's Medical University." Internal Medicine (Tokyo, Japan), vol. 40, no. 10, 2001, pp. 987-92.
    Fukuda I, Hizuka N, Murakami Y, et al. Clinical features and therapeutic outcomes of 65 patients with acromegaly at Tokyo Women's Medical University. Intern Med. 2001;40(10):987-92.
    Fukuda, I., Hizuka, N., Murakami, Y., Itoh, E., Yasumoto, K., Sata, A., & Takano, K. (2001). Clinical features and therapeutic outcomes of 65 patients with acromegaly at Tokyo Women's Medical University. Internal Medicine (Tokyo, Japan), 40(10), pp. 987-92.
    Fukuda I, et al. Clinical Features and Therapeutic Outcomes of 65 Patients With Acromegaly at Tokyo Women's Medical University. Intern Med. 2001;40(10):987-92. PubMed PMID: 11688841.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Clinical features and therapeutic outcomes of 65 patients with acromegaly at Tokyo Women's Medical University. AU - Fukuda,I, AU - Hizuka,N, AU - Murakami,Y, AU - Itoh,E, AU - Yasumoto,K, AU - Sata,A, AU - Takano,K, PY - 2001/11/2/pubmed PY - 2002/3/28/medline PY - 2001/11/2/entrez SP - 987 EP - 92 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 40 IS - 10 N2 - OBJECTIVE: The purpose of this study was to survey the clinical characteristics, complications, and therapeutic outcome in patients with acromegaly. PATIENTS AND METHODS: The clinical features of 65 patients with acromegaly (31 males, 34 females; mean age: 50+/-2 yr.) who were admitted to Tokyo Women's Medical University between 1990 and 1999 were analyzed retrospectively from medical records. RESULTS: The retrospective analysis revealed that the diagnosis of acromegaly was preceded by approximately 8.1+/-1.1 years of signs and symptoms of the disease. Forty-six of the 65 patients (71%) had macroadenomas, 16 (25%) had microadenomas, and the remaining three had empty sella. The rate of biochemical cure or remission was 81% for microadenoma (13/16), 64% for macroadenoma without extrasellar extension (9/14), and 13% for macroadenoma with cavernous sinus extension (2/15). Eighteen (28%) patients had impaired glucose tolerance (IGT) and 32 (49%) had diabetes mellitus (DM). After treatment for acromegaly, glucose metabolism was analyzed again in 38 patients, and it improved in 26 patients with IGT or DM. Twenty-five of 65 patients (38%) had hypertension. Of 26 patients who underwent barium enema or colonoscopy, 10 had colonic polyps and 4 had colon cancer. CONCLUSION: This study suggests that long-term excessive growth hormone (GH) secretion causes many complications. Therefore, awareness of the early symptoms and signs of acromegaly and long-term careful management of complications, along with therapy to reduce serum GH/insulin-like growth factor (IGF)-I levels, are important for patients with acromegaly. SN - 0918-2918 UR - https://www.unboundmedicine.com/medline/citation/11688841/full_citation L2 - http://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/40.987?from=PubMed DB - PRIME DP - Unbound Medicine ER -