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Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency. A randomized, controlled trial.
Ann Intern Med 2001; 135(11):965-76AIM

Abstract

BACKGROUND

Chronic renal insufficiency leads to muscle wasting, which may be exacerbated by low-protein diets prescribed to delay disease progression. Resistance training increases protein utilization and muscle mass.

OBJECTIVE

To determine the efficacy of resistance training in improving protein utilization and muscle mass in patients with chronic renal insufficiency treated with a low-protein diet.

DESIGN

Randomized, controlled trial.

SETTING

Tufts University, Boston, Massachusetts.

PATIENTS

26 older patients with moderate renal insufficiency (17 men, 9 women) who had achieved stabilization on a low-protein diet.

INTERVENTION

During a run-in period of 2 to 8 weeks, patients were instructed and their adherence to the low-protein diet (0.6 g/kg of body weight per day) was evaluated. They were randomly assigned to a low-protein diet plus resistance training (n = 14) or a low-protein diet alone (n = 12) for 12 weeks.

MEASUREMENTS

Total body potassium, mid-thigh muscle area, type I and II muscle-fiber cross-sectional area, and protein turnover.

RESULTS

Mean protein intake was 0.64 +/- 0.07 g/kg per day after stabilization. Total body potassium and type I and II muscle-fiber cross-sectional areas increased in patients who performed resistance training by a mean (+/-SD) of 4% +/- 8%, 24% +/- 31%, and 22% +/- 29%, respectively, compared with those who did not. Leucine oxidation and serum prealbumin levels also improved significantly. Patients assigned to resistance training maintained body weight compared with those who were not. Improvement in muscle strength was significantly greater with resistance training (32% +/- 14%) than without (-13% +/- 20%) (P < 0.001).

CONCLUSION

By improving muscle mass, nutritional status, and function, resistance training seems to be effective against the catabolism of a low-protein diet and uremia in patients with renal failure.

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    Authors+Show Affiliations

    Castaneda C
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA. ccastaneda@hnrc.tufts.edu
    Gordon PL
    No affiliation info available
    Uhlin KL
    No affiliation info available
    Levey AS
    No affiliation info available
    Kehayias JJ
    No affiliation info available
    Dwyer JT
    No affiliation info available
    Fielding RA
    No affiliation info available
    Roubenoff R
    No affiliation info available
    Singh MF
    No affiliation info available

    MeSH

    AgedBody WeightCombined Modality TherapyDiet, Protein-RestrictedExercise TherapyFemaleHumansKidney Failure, ChronicLeucineMaleMiddle AgedMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchMuscle ProteinsMuscle, SkeletalOxidation-ReductionPatient CompliancePotassiumPrealbuminThighWeight Lifting

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11730397

    Citation

    Castaneda, C, et al. "Resistance Training to Counteract the Catabolism of a Low-protein Diet in Patients With Chronic Renal Insufficiency. a Randomized, Controlled Trial." Annals of Internal Medicine, vol. 135, no. 11, 2001, pp. 965-76.
    Castaneda C, Gordon PL, Uhlin KL, et al. Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency. A randomized, controlled trial. Ann Intern Med. 2001;135(11):965-76.
    Castaneda, C., Gordon, P. L., Uhlin, K. L., Levey, A. S., Kehayias, J. J., Dwyer, J. T., ... Singh, M. F. (2001). Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency. A randomized, controlled trial. Annals of Internal Medicine, 135(11), pp. 965-76.
    Castaneda C, et al. Resistance Training to Counteract the Catabolism of a Low-protein Diet in Patients With Chronic Renal Insufficiency. a Randomized, Controlled Trial. Ann Intern Med. 2001 Dec 4;135(11):965-76. PubMed PMID: 11730397.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency. A randomized, controlled trial. AU - Castaneda,C, AU - Gordon,P L, AU - Uhlin,K L, AU - Levey,A S, AU - Kehayias,J J, AU - Dwyer,J T, AU - Fielding,R A, AU - Roubenoff,R, AU - Singh,M F, PY - 2001/12/4/pubmed PY - 2002/1/5/medline PY - 2001/12/4/entrez SP - 965 EP - 76 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 135 IS - 11 N2 - BACKGROUND: Chronic renal insufficiency leads to muscle wasting, which may be exacerbated by low-protein diets prescribed to delay disease progression. Resistance training increases protein utilization and muscle mass. OBJECTIVE: To determine the efficacy of resistance training in improving protein utilization and muscle mass in patients with chronic renal insufficiency treated with a low-protein diet. DESIGN: Randomized, controlled trial. SETTING: Tufts University, Boston, Massachusetts. PATIENTS: 26 older patients with moderate renal insufficiency (17 men, 9 women) who had achieved stabilization on a low-protein diet. INTERVENTION: During a run-in period of 2 to 8 weeks, patients were instructed and their adherence to the low-protein diet (0.6 g/kg of body weight per day) was evaluated. They were randomly assigned to a low-protein diet plus resistance training (n = 14) or a low-protein diet alone (n = 12) for 12 weeks. MEASUREMENTS: Total body potassium, mid-thigh muscle area, type I and II muscle-fiber cross-sectional area, and protein turnover. RESULTS: Mean protein intake was 0.64 +/- 0.07 g/kg per day after stabilization. Total body potassium and type I and II muscle-fiber cross-sectional areas increased in patients who performed resistance training by a mean (+/-SD) of 4% +/- 8%, 24% +/- 31%, and 22% +/- 29%, respectively, compared with those who did not. Leucine oxidation and serum prealbumin levels also improved significantly. Patients assigned to resistance training maintained body weight compared with those who were not. Improvement in muscle strength was significantly greater with resistance training (32% +/- 14%) than without (-13% +/- 20%) (P < 0.001). CONCLUSION: By improving muscle mass, nutritional status, and function, resistance training seems to be effective against the catabolism of a low-protein diet and uremia in patients with renal failure. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/11730397/full_citation L2 - https://www.annals.org/article.aspx?volume=135&amp;issue=11&amp;page=965 DB - PRIME DP - Unbound Medicine ER -