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Effect of zinc supplementation on growth and body composition in children with sickle cell disease.

Abstract

BACKGROUND

Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency.

OBJECTIVE

The objective was to determine the effects of zinc supplementation on growth and body composition in children with SCD.

DESIGN

Forty-two prepubertal children (20 girls and 22 boys) aged 4-10 y with SCD-SS were randomly assigned to receive 10 mg elemental Zn/d in cherry syrup (zinc group) or cherry syrup alone (control group). The 2 groups were stratified by sex and initial height status. Dietary intakes were evaluated and anthropometric, high-precision knee-height, and plasma zinc measurements were made at baseline and at 3, 6, and 12 mo. Body composition was determined every 6 mo with dual-energy X-ray absorptiometry, and z scores for anthropometric variables were computed from national reference data. Longitudinal-mixed-effects analysis was used to test for differences between the groups over the 12-mo observation period.

RESULTS

Thirty-eight children completed the study. No significant differences were observed at baseline. After 12 mo, the zinc group had significantly greater mean (+/- SE) increases in height (0.66 +/- 0.29 cm/y), sitting height (0.97 +/- 0.40 cm/y), knee height (3.8 +/- 1.2 mm/y), and arm circumference z scores (0.27 +/- 0.12 cm/y). Height-for-age and weight-for-age z scores decreased significantly by 0.11 +/- 0.04 and 0.13 +/- 0.05, respectively, in the control group but did not change significantly in the zinc group.

CONCLUSIONS

Prepubertal children with SCD-SS may have zinc deficiency and may benefit from zinc supplementation to improve linear growth and weight gain.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, the University of Pennsylvania School of Medicine, Philadelphia, 19104-4399, USA. zemel@email.chop.edu

    , , ,

    Source

    MeSH

    Body Composition
    Body Height
    Body Weight
    Child
    Child, Preschool
    Developmental Disabilities
    Diet
    Female
    Humans
    Male
    Nutritional Status
    Sickle Cell Trait
    Zinc

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11815322

    Citation

    Zemel, Babette S., et al. "Effect of Zinc Supplementation On Growth and Body Composition in Children With Sickle Cell Disease." The American Journal of Clinical Nutrition, vol. 75, no. 2, 2002, pp. 300-7.
    Zemel BS, Kawchak DA, Fung EB, et al. Effect of zinc supplementation on growth and body composition in children with sickle cell disease. Am J Clin Nutr. 2002;75(2):300-7.
    Zemel, B. S., Kawchak, D. A., Fung, E. B., Ohene-Frempong, K., & Stallings, V. A. (2002). Effect of zinc supplementation on growth and body composition in children with sickle cell disease. The American Journal of Clinical Nutrition, 75(2), pp. 300-7.
    Zemel BS, et al. Effect of Zinc Supplementation On Growth and Body Composition in Children With Sickle Cell Disease. Am J Clin Nutr. 2002;75(2):300-7. PubMed PMID: 11815322.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of zinc supplementation on growth and body composition in children with sickle cell disease. AU - Zemel,Babette S, AU - Kawchak,Deborah A, AU - Fung,Ellen B, AU - Ohene-Frempong,Kwaku, AU - Stallings,Virginia A, PY - 2002/1/30/pubmed PY - 2002/2/13/medline PY - 2002/1/30/entrez SP - 300 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 75 IS - 2 N2 - BACKGROUND: Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency. OBJECTIVE: The objective was to determine the effects of zinc supplementation on growth and body composition in children with SCD. DESIGN: Forty-two prepubertal children (20 girls and 22 boys) aged 4-10 y with SCD-SS were randomly assigned to receive 10 mg elemental Zn/d in cherry syrup (zinc group) or cherry syrup alone (control group). The 2 groups were stratified by sex and initial height status. Dietary intakes were evaluated and anthropometric, high-precision knee-height, and plasma zinc measurements were made at baseline and at 3, 6, and 12 mo. Body composition was determined every 6 mo with dual-energy X-ray absorptiometry, and z scores for anthropometric variables were computed from national reference data. Longitudinal-mixed-effects analysis was used to test for differences between the groups over the 12-mo observation period. RESULTS: Thirty-eight children completed the study. No significant differences were observed at baseline. After 12 mo, the zinc group had significantly greater mean (+/- SE) increases in height (0.66 +/- 0.29 cm/y), sitting height (0.97 +/- 0.40 cm/y), knee height (3.8 +/- 1.2 mm/y), and arm circumference z scores (0.27 +/- 0.12 cm/y). Height-for-age and weight-for-age z scores decreased significantly by 0.11 +/- 0.04 and 0.13 +/- 0.05, respectively, in the control group but did not change significantly in the zinc group. CONCLUSIONS: Prepubertal children with SCD-SS may have zinc deficiency and may benefit from zinc supplementation to improve linear growth and weight gain. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11815322/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/75.2.300 DB - PRIME DP - Unbound Medicine ER -