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Effect of zinc supplementation on growth and body composition in children with sickle cell disease.

Abstract

BACKGROUND

Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency.

OBJECTIVE

The objective was to determine the effects of zinc supplementation on growth and body composition in children with SCD.

DESIGN

Forty-two prepubertal children (20 girls and 22 boys) aged 4-10 y with SCD-SS were randomly assigned to receive 10 mg elemental Zn/d in cherry syrup (zinc group) or cherry syrup alone (control group). The 2 groups were stratified by sex and initial height status. Dietary intakes were evaluated and anthropometric, high-precision knee-height, and plasma zinc measurements were made at baseline and at 3, 6, and 12 mo. Body composition was determined every 6 mo with dual-energy X-ray absorptiometry, and z scores for anthropometric variables were computed from national reference data. Longitudinal-mixed-effects analysis was used to test for differences between the groups over the 12-mo observation period.

RESULTS

Thirty-eight children completed the study. No significant differences were observed at baseline. After 12 mo, the zinc group had significantly greater mean (+/- SE) increases in height (0.66 +/- 0.29 cm/y), sitting height (0.97 +/- 0.40 cm/y), knee height (3.8 +/- 1.2 mm/y), and arm circumference z scores (0.27 +/- 0.12 cm/y). Height-for-age and weight-for-age z scores decreased significantly by 0.11 +/- 0.04 and 0.13 +/- 0.05, respectively, in the control group but did not change significantly in the zinc group.

CONCLUSIONS

Prepubertal children with SCD-SS may have zinc deficiency and may benefit from zinc supplementation to improve linear growth and weight gain.

Links

Authors+Show Affiliations

,

Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, the University of Pennsylvania School of Medicine, Philadelphia, 19104-4399, USA. zemel@email.chop.edu

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Source

MeSH

Body Composition
Body Height
Body Weight
Child
Child, Preschool
Developmental Disabilities
Diet
Female
Humans
Male
Nutritional Status
Sickle Cell Trait
Zinc

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11815322

Citation

TY - JOUR T1 - Effect of zinc supplementation on growth and body composition in children with sickle cell disease. AU - Zemel,Babette S, AU - Kawchak,Deborah A, AU - Fung,Ellen B, AU - Ohene-Frempong,Kwaku, AU - Stallings,Virginia A, PY - 2002/1/30/pubmed PY - 2002/2/13/medline PY - 2002/1/30/entrez SP - 300 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 75 IS - 2 N2 - BACKGROUND: Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency. OBJECTIVE: The objective was to determine the effects of zinc supplementation on growth and body composition in children with SCD. DESIGN: Forty-two prepubertal children (20 girls and 22 boys) aged 4-10 y with SCD-SS were randomly assigned to receive 10 mg elemental Zn/d in cherry syrup (zinc group) or cherry syrup alone (control group). The 2 groups were stratified by sex and initial height status. Dietary intakes were evaluated and anthropometric, high-precision knee-height, and plasma zinc measurements were made at baseline and at 3, 6, and 12 mo. Body composition was determined every 6 mo with dual-energy X-ray absorptiometry, and z scores for anthropometric variables were computed from national reference data. Longitudinal-mixed-effects analysis was used to test for differences between the groups over the 12-mo observation period. RESULTS: Thirty-eight children completed the study. No significant differences were observed at baseline. After 12 mo, the zinc group had significantly greater mean (+/- SE) increases in height (0.66 +/- 0.29 cm/y), sitting height (0.97 +/- 0.40 cm/y), knee height (3.8 +/- 1.2 mm/y), and arm circumference z scores (0.27 +/- 0.12 cm/y). Height-for-age and weight-for-age z scores decreased significantly by 0.11 +/- 0.04 and 0.13 +/- 0.05, respectively, in the control group but did not change significantly in the zinc group. CONCLUSIONS: Prepubertal children with SCD-SS may have zinc deficiency and may benefit from zinc supplementation to improve linear growth and weight gain. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11815322/full_citation L2 - http://www.diseaseinfosearch.org/result/6589 ER -