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Effect of calories and fat on postprandial gastro-oesophageal reflux.
Scand J Gastroenterol 2002; 37(1):3-5SJ

Abstract

BACKGROUND

Gastro-oesophageal reflux (GOR) is commonly considered to be worsened by fatty food, but it has recently been shown that changing the fat content of equicaloric meals has no effect on GOR over a 3-h postprandial period. Our aims were to verify this finding over a longer postprandial period and test the hypothesis that increasing the caloric content of balanced meals increases GOR.

METHODS

Thirteen healthy subjects (6 men) aged 19-31 years underwent 6-h oesophageal pH monitoring after 3 solid/liquid meals of the same volume and osmolarity eaten on separate days in a randomized order: a) high fat (58% fat) 2.8 MJ; b) balanced (23% fat) 2.8 MJ; and c) balanced low calorie (25% fat) 1.6 MJ.

RESULTS

The mean percentage of time at pH < 4 and the mean number of reflux episodes after the balanced 2.8 MJ meal (3.0% and 11.5. respectively) were higher (P < 0.05) than after the balanced 1.6 MJ meal (1.6% and 7.2) and similar to those after the equicaloric (2.8 MJ) high-fat meal (2.5% and 9.3). Acid clearance time was similar after all three meals.

CONCLUSIONS

Our data suggest that advice on dietary habits in patients with GOR disease should be concentrated on decreasing the caloric load of meals rather than their fat content.

Authors+Show Affiliations

Cattedra di Gastroenterologia, Dipartimento di Scienze Mediche, University of Milan, IRCCS Ospedale Maggiore, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11843031

Citation

Colombo, P, et al. "Effect of Calories and Fat On Postprandial Gastro-oesophageal Reflux." Scandinavian Journal of Gastroenterology, vol. 37, no. 1, 2002, pp. 3-5.
Colombo P, Mangano M, Bianchi PA, et al. Effect of calories and fat on postprandial gastro-oesophageal reflux. Scand J Gastroenterol. 2002;37(1):3-5.
Colombo, P., Mangano, M., Bianchi, P. A., & Penagini, R. (2002). Effect of calories and fat on postprandial gastro-oesophageal reflux. Scandinavian Journal of Gastroenterology, 37(1), pp. 3-5.
Colombo P, et al. Effect of Calories and Fat On Postprandial Gastro-oesophageal Reflux. Scand J Gastroenterol. 2002;37(1):3-5. PubMed PMID: 11843031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of calories and fat on postprandial gastro-oesophageal reflux. AU - Colombo,P, AU - Mangano,M, AU - Bianchi,P A, AU - Penagini,R, PY - 2002/2/15/pubmed PY - 2002/7/27/medline PY - 2002/2/15/entrez SP - 3 EP - 5 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 37 IS - 1 N2 - BACKGROUND: Gastro-oesophageal reflux (GOR) is commonly considered to be worsened by fatty food, but it has recently been shown that changing the fat content of equicaloric meals has no effect on GOR over a 3-h postprandial period. Our aims were to verify this finding over a longer postprandial period and test the hypothesis that increasing the caloric content of balanced meals increases GOR. METHODS: Thirteen healthy subjects (6 men) aged 19-31 years underwent 6-h oesophageal pH monitoring after 3 solid/liquid meals of the same volume and osmolarity eaten on separate days in a randomized order: a) high fat (58% fat) 2.8 MJ; b) balanced (23% fat) 2.8 MJ; and c) balanced low calorie (25% fat) 1.6 MJ. RESULTS: The mean percentage of time at pH < 4 and the mean number of reflux episodes after the balanced 2.8 MJ meal (3.0% and 11.5. respectively) were higher (P < 0.05) than after the balanced 1.6 MJ meal (1.6% and 7.2) and similar to those after the equicaloric (2.8 MJ) high-fat meal (2.5% and 9.3). Acid clearance time was similar after all three meals. CONCLUSIONS: Our data suggest that advice on dietary habits in patients with GOR disease should be concentrated on decreasing the caloric load of meals rather than their fat content. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/11843031/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/003655202753387266 DB - PRIME DP - Unbound Medicine ER -