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Improvement of symptoms in infant colic following reduction of lactose load with lactase.

Abstract

Transient lactose intolerance has been identified as a possible causative factor in infant colic. A double-blind randomised placebo-controlled crossover study to investigate this has been undertaken in 53 babies with symptoms of colic. Pre-incubation of the feed with lactase resulted in breath hydrogen levels and total crying time which were both at least 45% lower than figures with placebo treatment, in 26% of the full trial group (95% confidence interval 12.9% to 44.4%), and in 38% of compliers (95% confidence interval 18.8% to 59.4%). The remainder did not respond to the same extent. These findings suggest that infant colic may have a multiple aetiology, and that in a significant number of cases the immediate cause is transient lactose intolerance, in which cases pretreatment of feeds with lactase can result in considerable symptomatic benefits.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Paediatrics, Guy's Hospital, London, UK.

    ,

    Source

    MeSH

    Breath Tests
    Colic
    Cross-Over Studies
    Crying
    Double-Blind Method
    Humans
    Hydrogen
    Infant
    Infant, Newborn
    Lactase
    Lactose
    Lactose Intolerance
    Time Factors
    beta-Galactosidase

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11906576

    Citation

    Kanabar, D, et al. "Improvement of Symptoms in Infant Colic Following Reduction of Lactose Load With Lactase." Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, vol. 14, no. 5, 2001, pp. 359-63.
    Kanabar D, Randhawa M, Clayton P. Improvement of symptoms in infant colic following reduction of lactose load with lactase. J Hum Nutr Diet. 2001;14(5):359-63.
    Kanabar, D., Randhawa, M., & Clayton, P. (2001). Improvement of symptoms in infant colic following reduction of lactose load with lactase. Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, 14(5), pp. 359-63.
    Kanabar D, Randhawa M, Clayton P. Improvement of Symptoms in Infant Colic Following Reduction of Lactose Load With Lactase. J Hum Nutr Diet. 2001;14(5):359-63. PubMed PMID: 11906576.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Improvement of symptoms in infant colic following reduction of lactose load with lactase. AU - Kanabar,D, AU - Randhawa,M, AU - Clayton,P, PY - 2002/3/22/pubmed PY - 2002/4/17/medline PY - 2002/3/22/entrez SP - 359 EP - 63 JF - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JO - J Hum Nutr Diet VL - 14 IS - 5 N2 - Transient lactose intolerance has been identified as a possible causative factor in infant colic. A double-blind randomised placebo-controlled crossover study to investigate this has been undertaken in 53 babies with symptoms of colic. Pre-incubation of the feed with lactase resulted in breath hydrogen levels and total crying time which were both at least 45% lower than figures with placebo treatment, in 26% of the full trial group (95% confidence interval 12.9% to 44.4%), and in 38% of compliers (95% confidence interval 18.8% to 59.4%). The remainder did not respond to the same extent. These findings suggest that infant colic may have a multiple aetiology, and that in a significant number of cases the immediate cause is transient lactose intolerance, in which cases pretreatment of feeds with lactase can result in considerable symptomatic benefits. SN - 0952-3871 UR - https://www.unboundmedicine.com/medline/citation/11906576/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0952-3871&date=2001&volume=14&issue=5&spage=359 DB - PRIME DP - Unbound Medicine ER -