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Intestinal permeation and gastrointestinal disease.

Abstract

The gastrointestinal tract constitutes one of the largest sites of exposure to the outside environment. The function of the gastrointestinal tract in monitoring and sealing the host interior from intruders is called the gut barrier. A variety of specific and nonspecific mechanisms are in operation to establish the host barrier; these include luminal mechanisms and digestive enzymes, the epithelial cells together with tight junctions in between them, and the gut immune system. Disruptions in the gut barrier follow injury from various causes including nonsteroidal anti-inflammatory drugs and oxidant stress, and involve mechanisms such as adenosine triphosphate depletion and damage to epithelial cell cytoskeletons that regulate tight junctions. Ample evidence links gut barrier dysfunction to multiorgan system failure in sepsis and immune dysregulation. Additionally, contribution of gut barrier dysfunction to gastrointestinal disease is an evolving concept and is the focus of this review. An overview of the evidence for the role of gut barrier dysfunction in disorders such as Crohn's disease, celiac disease, food allergy, acute pancreatitis, non-alcoholic fatty liver disease, and alcoholic liver disease is provided, together with critical insight into the implications of this evidence as a primary disease mechanism.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Gastroenterology and Nutrition, Rush University, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA. mark_t_demeo@rush.edu

    , ,

    Source

    Journal of clinical gastroenterology 34:4 2002 Apr pg 385-96

    MeSH

    Acute Disease
    Celiac Disease
    Crohn Disease
    Digestive System
    Food Hypersensitivity
    Gastric Acid
    Humans
    Hydrogen-Ion Concentration
    Liver Diseases
    Pancreatitis
    Permeability

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    11907349

    Citation

    DeMeo, Mark T., et al. "Intestinal Permeation and Gastrointestinal Disease." Journal of Clinical Gastroenterology, vol. 34, no. 4, 2002, pp. 385-96.
    DeMeo MT, Mutlu EA, Keshavarzian A, et al. Intestinal permeation and gastrointestinal disease. J Clin Gastroenterol. 2002;34(4):385-96.
    DeMeo, M. T., Mutlu, E. A., Keshavarzian, A., & Tobin, M. C. (2002). Intestinal permeation and gastrointestinal disease. Journal of Clinical Gastroenterology, 34(4), pp. 385-96.
    DeMeo MT, et al. Intestinal Permeation and Gastrointestinal Disease. J Clin Gastroenterol. 2002;34(4):385-96. PubMed PMID: 11907349.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intestinal permeation and gastrointestinal disease. AU - DeMeo,Mark T, AU - Mutlu,Ece A, AU - Keshavarzian,Ali, AU - Tobin,Mary C, PY - 2002/3/22/pubmed PY - 2002/5/3/medline PY - 2002/3/22/entrez SP - 385 EP - 96 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 34 IS - 4 N2 - The gastrointestinal tract constitutes one of the largest sites of exposure to the outside environment. The function of the gastrointestinal tract in monitoring and sealing the host interior from intruders is called the gut barrier. A variety of specific and nonspecific mechanisms are in operation to establish the host barrier; these include luminal mechanisms and digestive enzymes, the epithelial cells together with tight junctions in between them, and the gut immune system. Disruptions in the gut barrier follow injury from various causes including nonsteroidal anti-inflammatory drugs and oxidant stress, and involve mechanisms such as adenosine triphosphate depletion and damage to epithelial cell cytoskeletons that regulate tight junctions. Ample evidence links gut barrier dysfunction to multiorgan system failure in sepsis and immune dysregulation. Additionally, contribution of gut barrier dysfunction to gastrointestinal disease is an evolving concept and is the focus of this review. An overview of the evidence for the role of gut barrier dysfunction in disorders such as Crohn's disease, celiac disease, food allergy, acute pancreatitis, non-alcoholic fatty liver disease, and alcoholic liver disease is provided, together with critical insight into the implications of this evidence as a primary disease mechanism. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/11907349/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=11907349 DB - PRIME DP - Unbound Medicine ER -