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Dietary fat reduction to reduce prostate cancer risk: controlled enthusiasm, learning a lesson from breast or other cancers, and the big picture.

Abstract

Breast and prostate cancer share similar intrinsic and extrinsic risk factors. Based on laboratory, ecologic/international comparison, and case-control studies, the impact of dietary fat or other fat subtypes has been suggested as a potential route to reduce risk. Recent large-scale prospective studies have failed to find an association between fat and breast cancer risk. These studies may provide some insight for researchers examining the relation between fat and prostate cancer. Prospective studies to date have also failed to find a consistent association between prostate cancer and fat intake. Some fat subtypes (eg, saturated fat) or other lifestyle changes (eg, obesity, physical activity) may affect risk and progression of these cancers when examining the sum total of the research, but more precise and specific investigations in humans are needed to address these issues. Other concerns, such as the impact of excess energy or overall caloric consumption on carcinogenesis, still need to be addressed, as well as other methodologic limitations of past investigations. Large gaps exist in environmental (eg, diet, lifestyle) and heritable causes of these diseases. Regardless, until more extensive research is completed, lifestyle changes should be recommended based on reducing morbidity and mortality from cardiovascular disease-the number 1 cause of death in the United States. Additionally, cardiovascular disease remains the number 1 or 2 cause of death in patients diagnosed with breast or prostate cancer. Practical and simple dietary changes should be encouraged by health professionals because they could improve the overall longevity and quality of patients' lives. Numerous ongoing prospective studies of diet and cancer should provide researchers and the public with much-needed answers in this area.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Urology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0330, USA. moyad@umich.edu

    Source

    Urology 59:4 Suppl 1 2002 Apr pg 51-62

    MeSH

    Animals
    Breast Neoplasms
    Case-Control Studies
    Cohort Studies
    Diet, Fat-Restricted
    Female
    Humans
    Male
    Prospective Studies
    Prostatic Neoplasms
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    11937436

    Citation

    Moyad, Mark A.. "Dietary Fat Reduction to Reduce Prostate Cancer Risk: Controlled Enthusiasm, Learning a Lesson From Breast or Other Cancers, and the Big Picture." Urology, vol. 59, no. 4 Suppl 1, 2002, pp. 51-62.
    Moyad MA. Dietary fat reduction to reduce prostate cancer risk: controlled enthusiasm, learning a lesson from breast or other cancers, and the big picture. Urology. 2002;59(4 Suppl 1):51-62.
    Moyad, M. A. (2002). Dietary fat reduction to reduce prostate cancer risk: controlled enthusiasm, learning a lesson from breast or other cancers, and the big picture. Urology, 59(4 Suppl 1), pp. 51-62.
    Moyad MA. Dietary Fat Reduction to Reduce Prostate Cancer Risk: Controlled Enthusiasm, Learning a Lesson From Breast or Other Cancers, and the Big Picture. Urology. 2002;59(4 Suppl 1):51-62. PubMed PMID: 11937436.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat reduction to reduce prostate cancer risk: controlled enthusiasm, learning a lesson from breast or other cancers, and the big picture. A1 - Moyad,Mark A, PY - 2002/4/9/pubmed PY - 2002/4/11/medline PY - 2002/4/9/entrez SP - 51 EP - 62 JF - Urology JO - Urology VL - 59 IS - 4 Suppl 1 N2 - Breast and prostate cancer share similar intrinsic and extrinsic risk factors. Based on laboratory, ecologic/international comparison, and case-control studies, the impact of dietary fat or other fat subtypes has been suggested as a potential route to reduce risk. Recent large-scale prospective studies have failed to find an association between fat and breast cancer risk. These studies may provide some insight for researchers examining the relation between fat and prostate cancer. Prospective studies to date have also failed to find a consistent association between prostate cancer and fat intake. Some fat subtypes (eg, saturated fat) or other lifestyle changes (eg, obesity, physical activity) may affect risk and progression of these cancers when examining the sum total of the research, but more precise and specific investigations in humans are needed to address these issues. Other concerns, such as the impact of excess energy or overall caloric consumption on carcinogenesis, still need to be addressed, as well as other methodologic limitations of past investigations. Large gaps exist in environmental (eg, diet, lifestyle) and heritable causes of these diseases. Regardless, until more extensive research is completed, lifestyle changes should be recommended based on reducing morbidity and mortality from cardiovascular disease-the number 1 cause of death in the United States. Additionally, cardiovascular disease remains the number 1 or 2 cause of death in patients diagnosed with breast or prostate cancer. Practical and simple dietary changes should be encouraged by health professionals because they could improve the overall longevity and quality of patients' lives. Numerous ongoing prospective studies of diet and cancer should provide researchers and the public with much-needed answers in this area. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/11937436/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090429501011761 DB - PRIME DP - Unbound Medicine ER -