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Prospective study of diet and pancreatic cancer in male smokers.

Abstract

There have been few prospective studies relating diet to pancreatic cancer, with most having fewer than 100 cases and only one examining dietary nutrients. The authors prospectively examined dietary factors hypothesized to be associated with exocrine pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort in Finland. Of the 27,111 male smokers aged 50-69 years with complete dietary information, as ascertained from a self-administered dietary history questionnaire given at baseline (1985-1988), 163 developed pancreatic cancer from 1985 through November 1997. Cox proportional hazards models were used to estimate smoking- and age-adjusted hazard ratios and 95% confidence intervals. Energy-adjusted butter consumption and saturated fat intake were positively associated with pancreatic cancer (highest quintile vs. lowest: hazard ratio (HR) = 1.40, 95% confidence interval (CI): 0.87, 2.25 (p trend = 0.04), and HR = 1.60, 95% CI: 0.96, 2.64 (p trend = 0.02), respectively). Energy intake and energy-adjusted carbohydrate intake were inversely associated with the disease (highest quintile vs. lowest: HR = 0.62, 95% CI: 0.36, 1.07 (p trend = 0.05), and HR = 0.62, 95% CI: 0.37, 1.03 (p trend = 0.02), respectively). These results support the hypothesis that a high intake of saturated fat may increase the risk of pancreatic cancer in smokers, while greater intakes of energy and carbohydrate may reduce the risk.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7232, USA. rs221z@nih.gov

    , , ,

    Source

    American journal of epidemiology 155:9 2002 May 01 pg 783-92

    MeSH

    Aged
    Chi-Square Distribution
    Diet
    Dietary Carbohydrates
    Dietary Fats
    Energy Intake
    Finland
    Humans
    Male
    Middle Aged
    Pancreatic Neoplasms
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Smoking
    Statistics, Nonparametric
    Surveys and Questionnaires
    alpha-Tocopherol
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11978580

    Citation

    Stolzenberg-Solomon, Rachael Z., et al. "Prospective Study of Diet and Pancreatic Cancer in Male Smokers." American Journal of Epidemiology, vol. 155, no. 9, 2002, pp. 783-92.
    Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, et al. Prospective study of diet and pancreatic cancer in male smokers. Am J Epidemiol. 2002;155(9):783-92.
    Stolzenberg-Solomon, R. Z., Pietinen, P., Taylor, P. R., Virtamo, J., & Albanes, D. (2002). Prospective study of diet and pancreatic cancer in male smokers. American Journal of Epidemiology, 155(9), pp. 783-92.
    Stolzenberg-Solomon RZ, et al. Prospective Study of Diet and Pancreatic Cancer in Male Smokers. Am J Epidemiol. 2002 May 1;155(9):783-92. PubMed PMID: 11978580.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study of diet and pancreatic cancer in male smokers. AU - Stolzenberg-Solomon,Rachael Z, AU - Pietinen,Pirjo, AU - Taylor,Philip R, AU - Virtamo,Jarmo, AU - Albanes,Demetrius, PY - 2002/4/30/pubmed PY - 2002/5/25/medline PY - 2002/4/30/entrez SP - 783 EP - 92 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 155 IS - 9 N2 - There have been few prospective studies relating diet to pancreatic cancer, with most having fewer than 100 cases and only one examining dietary nutrients. The authors prospectively examined dietary factors hypothesized to be associated with exocrine pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort in Finland. Of the 27,111 male smokers aged 50-69 years with complete dietary information, as ascertained from a self-administered dietary history questionnaire given at baseline (1985-1988), 163 developed pancreatic cancer from 1985 through November 1997. Cox proportional hazards models were used to estimate smoking- and age-adjusted hazard ratios and 95% confidence intervals. Energy-adjusted butter consumption and saturated fat intake were positively associated with pancreatic cancer (highest quintile vs. lowest: hazard ratio (HR) = 1.40, 95% confidence interval (CI): 0.87, 2.25 (p trend = 0.04), and HR = 1.60, 95% CI: 0.96, 2.64 (p trend = 0.02), respectively). Energy intake and energy-adjusted carbohydrate intake were inversely associated with the disease (highest quintile vs. lowest: HR = 0.62, 95% CI: 0.36, 1.07 (p trend = 0.05), and HR = 0.62, 95% CI: 0.37, 1.03 (p trend = 0.02), respectively). These results support the hypothesis that a high intake of saturated fat may increase the risk of pancreatic cancer in smokers, while greater intakes of energy and carbohydrate may reduce the risk. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/11978580/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/155.9.783 DB - PRIME DP - Unbound Medicine ER -