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Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial.
Int J Obes Relat Metab Disord 2002; 26(5):593-604IJ

Abstract

OBJECTIVE

To examine long-term safety and efficacy for weight loss of an herbal Ma Huang and Kola nut supplement (90/192 mg/day ephedrine alkaloids/caffeine).

DESIGN

Six-month randomized, double-blind placebo controlled trial.

SUBJECTS

A total of 167 subjects (body mass index (BMI) 31.8+/-4.1 kg/m(2)) randomized to placebo (n=84) or herbal treatment (n=83) at two outpatient weight control research units.

MEASUREMENTS

Primary outcome measurements were changes in blood pressure, heart function and body weight. Secondary variables included body composition and metabolic changes.

RESULTS

By last observation carried forward analysis, herbal vs placebo treatment decreased body weight (-5.3+/-5.0 vs. -2.6+/-3.2 kg, P<0.001), body fat (-4.3+/-3.3 vs. -2.7+/-2.8 kg, P=0.020) and LDL-cholesterol (-8+/-20 vs. 0+/-17 mg/dl, P=0.013), and increased HDL-cholesterol (+2.7+/-5.7 vs. -0.3+/-6.7 mg/dl, P=0.004). Herbal treatment produced small changes in blood pressure variables (+3 to -5 mm Hg, P< or =0.05), and increased heart rate (4+/-9 vs. -3+/-9 bpm, P<0.001), but cardiac arrhythmias were not increased (P>0.05). By self-report, dry mouth (P<0.01), heartburn (P<0.05), and insomnia (P<0.01) were increased and diarrhea decreased (P<0.05). Irritability, nausea, chest pain and palpitations did not differ, nor did numbers of subjects who withdrew.

CONCLUSIONS

In this 6-month placebo-controlled trial, herbal ephedra/caffeine (90/192 mg/day) promoted body weight and body fat reduction and improved blood lipids without significant adverse events.

Authors+Show Affiliations

New York Obesity Research Center, St Luke's-Roosevelt Hospital and Columbia University, New York 10025, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12032741

Citation

Boozer, C N., et al. "Herbal Ephedra/caffeine for Weight Loss: a 6-month Randomized Safety and Efficacy Trial." International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, vol. 26, no. 5, 2002, pp. 593-604.
Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord. 2002;26(5):593-604.
Boozer, C. N., Daly, P. A., Homel, P., Solomon, J. L., Blanchard, D., Nasser, J. A., ... Meredith, T. (2002). Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 26(5), pp. 593-604.
Boozer CN, et al. Herbal Ephedra/caffeine for Weight Loss: a 6-month Randomized Safety and Efficacy Trial. Int J Obes Relat Metab Disord. 2002;26(5):593-604. PubMed PMID: 12032741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. AU - Boozer,C N, AU - Daly,P A, AU - Homel,P, AU - Solomon,J L, AU - Blanchard,D, AU - Nasser,J A, AU - Strauss,R, AU - Meredith,T, PY - 2001/10/26/received PY - 2002/02/06/revised PY - 2002/02/11/accepted PY - 2002/5/29/pubmed PY - 2002/6/25/medline PY - 2002/5/29/entrez SP - 593 EP - 604 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity JO - Int. J. Obes. Relat. Metab. Disord. VL - 26 IS - 5 N2 - OBJECTIVE: To examine long-term safety and efficacy for weight loss of an herbal Ma Huang and Kola nut supplement (90/192 mg/day ephedrine alkaloids/caffeine). DESIGN: Six-month randomized, double-blind placebo controlled trial. SUBJECTS: A total of 167 subjects (body mass index (BMI) 31.8+/-4.1 kg/m(2)) randomized to placebo (n=84) or herbal treatment (n=83) at two outpatient weight control research units. MEASUREMENTS: Primary outcome measurements were changes in blood pressure, heart function and body weight. Secondary variables included body composition and metabolic changes. RESULTS: By last observation carried forward analysis, herbal vs placebo treatment decreased body weight (-5.3+/-5.0 vs. -2.6+/-3.2 kg, P<0.001), body fat (-4.3+/-3.3 vs. -2.7+/-2.8 kg, P=0.020) and LDL-cholesterol (-8+/-20 vs. 0+/-17 mg/dl, P=0.013), and increased HDL-cholesterol (+2.7+/-5.7 vs. -0.3+/-6.7 mg/dl, P=0.004). Herbal treatment produced small changes in blood pressure variables (+3 to -5 mm Hg, P< or =0.05), and increased heart rate (4+/-9 vs. -3+/-9 bpm, P<0.001), but cardiac arrhythmias were not increased (P>0.05). By self-report, dry mouth (P<0.01), heartburn (P<0.05), and insomnia (P<0.01) were increased and diarrhea decreased (P<0.05). Irritability, nausea, chest pain and palpitations did not differ, nor did numbers of subjects who withdrew. CONCLUSIONS: In this 6-month placebo-controlled trial, herbal ephedra/caffeine (90/192 mg/day) promoted body weight and body fat reduction and improved blood lipids without significant adverse events. UR - http://www.unboundmedicine.com/medline/citation/12032741/full_citation L2 - https://medlineplus.gov/weightcontrol.html DB - PRIME DP - Unbound Medicine ER -