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Obesity, weight gain, and ovarian cancer.

Abstract

OBJECTIVE

To investigate how adipose tissue alters endogenous hormone levels and may affect events at the ovarian tissue level.

METHODS

We assessed current weight, weight at age 18, and adult weight change in relation to ovarian cancer risk among 109,445 participants in the Nurses' Health Study. Women reported ovarian cancer risk factors and new ovarian cancer diagnoses in biennial mailed questionnaires from 1976 to 1996. Height and weight were queried in 1976, current weight was updated biennially, and weight at age 18 was ascertained in 1980. During 20 years of follow-up and 1,703,474 person-years, 402 cases of epithelial ovarian cancer were confirmed. We used pooled logistic regression to control for age, oral contraceptive use, smoking history, parity, age at menarche, and tubal ligation.

RESULTS

We found no evidence of an association between recent body mass index (BMI, kg/m(2)) and ovarian cancer risk. The multivariable relative risk for women with BMI of 30 kg/m(2) or higher versus BMI less than 21 kg/m(2) was 1.05 (95% confidence interval 0.73, 1.51). For BMI at age 18, there was no association with ovarian cancer risk overall, but a two-fold increase in premenopausal ovarian cancer risk associated with having a BMI at age 18 of 25 kg/m(2) or higher versus BMI less than 20 kg/m(2) (relative risk 2.05, 95% confidence interval 1.07, 3.93, P for trend =.01). Adult weight gain was not associated with ovarian cancer risk.

CONCLUSION

We found no evidence of an association between recent BMI or adult weight change and ovarian cancer risk. Higher BMI in young adulthood was associated with an increased risk of premenopausal ovarian cancer. If confirmed, these findings suggest an additional reason for avoiding adolescent obesity.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. kathleen.fairfield@channing.harvard.edu

    , , , ,

    Source

    Obstetrics and gynecology 100:2 2002 Aug pg 288-96

    MeSH

    Adolescent
    Adult
    Age Distribution
    Body Mass Index
    Cohort Studies
    Comorbidity
    Confidence Intervals
    Female
    Health Surveys
    Humans
    Incidence
    Middle Aged
    Multivariate Analysis
    Obesity
    Ovarian Neoplasms
    Probability
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    United States
    Weight Gain

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12151152

    Citation

    Fairfield, Kathleen M., et al. "Obesity, Weight Gain, and Ovarian Cancer." Obstetrics and Gynecology, vol. 100, no. 2, 2002, pp. 288-96.
    Fairfield KM, Willett WC, Rosner BA, et al. Obesity, weight gain, and ovarian cancer. Obstet Gynecol. 2002;100(2):288-96.
    Fairfield, K. M., Willett, W. C., Rosner, B. A., Manson, J. E., Speizer, F. E., & Hankinson, S. E. (2002). Obesity, weight gain, and ovarian cancer. Obstetrics and Gynecology, 100(2), pp. 288-96.
    Fairfield KM, et al. Obesity, Weight Gain, and Ovarian Cancer. Obstet Gynecol. 2002;100(2):288-96. PubMed PMID: 12151152.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Obesity, weight gain, and ovarian cancer. AU - Fairfield,Kathleen M, AU - Willett,Walter C, AU - Rosner,Bernard A, AU - Manson,JoAnn E, AU - Speizer,Frank E, AU - Hankinson,Susan E, PY - 2002/8/2/pubmed PY - 2002/8/23/medline PY - 2002/8/2/entrez SP - 288 EP - 96 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 100 IS - 2 N2 - OBJECTIVE: To investigate how adipose tissue alters endogenous hormone levels and may affect events at the ovarian tissue level. METHODS: We assessed current weight, weight at age 18, and adult weight change in relation to ovarian cancer risk among 109,445 participants in the Nurses' Health Study. Women reported ovarian cancer risk factors and new ovarian cancer diagnoses in biennial mailed questionnaires from 1976 to 1996. Height and weight were queried in 1976, current weight was updated biennially, and weight at age 18 was ascertained in 1980. During 20 years of follow-up and 1,703,474 person-years, 402 cases of epithelial ovarian cancer were confirmed. We used pooled logistic regression to control for age, oral contraceptive use, smoking history, parity, age at menarche, and tubal ligation. RESULTS: We found no evidence of an association between recent body mass index (BMI, kg/m(2)) and ovarian cancer risk. The multivariable relative risk for women with BMI of 30 kg/m(2) or higher versus BMI less than 21 kg/m(2) was 1.05 (95% confidence interval 0.73, 1.51). For BMI at age 18, there was no association with ovarian cancer risk overall, but a two-fold increase in premenopausal ovarian cancer risk associated with having a BMI at age 18 of 25 kg/m(2) or higher versus BMI less than 20 kg/m(2) (relative risk 2.05, 95% confidence interval 1.07, 3.93, P for trend =.01). Adult weight gain was not associated with ovarian cancer risk. CONCLUSION: We found no evidence of an association between recent BMI or adult weight change and ovarian cancer risk. Higher BMI in young adulthood was associated with an increased risk of premenopausal ovarian cancer. If confirmed, these findings suggest an additional reason for avoiding adolescent obesity. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/12151152/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0029784402020537 DB - PRIME DP - Unbound Medicine ER -