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Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine.

Abstract

Nonalcoholic steatotic hepatitis (NASH), the most prevalent form of progressive liver disease in the United States, is considered to be a manifestation of insulin resistance syndrome. There is increasing evidence that steatosis in NASH is a result of the pathology in fat metabolism occurring in obesity and insulin resistance. For steatosis to progress to necroinflammation and fibrosis, however, the theory of mitochondrial oxidative-stress induced cellular damage is receiving wide acceptance. Treatment approaches that address these etiologies are reviewed: betaine, magnesium, and vitamin E.

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  • Authors+Show Affiliations

    lpatrick@frontier.net

    Source

    MeSH

    Antioxidants
    Betaine
    Fatty Liver
    Female
    Humans
    Insulin Resistance
    Lipotropic Agents
    Liver
    Magnesium
    Obesity
    Oxidative Stress
    Vitamin E

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12197781

    Citation

    Patrick, Lyn. "Nonalcoholic Fatty Liver Disease: Relationship to Insulin Sensitivity and Oxidative Stress. Treatment Approaches Using Vitamin E, Magnesium, and Betaine." Alternative Medicine Review : a Journal of Clinical Therapeutic, vol. 7, no. 4, 2002, pp. 276-91.
    Patrick L. Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine. Altern Med Rev. 2002;7(4):276-91.
    Patrick, L. (2002). Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine. Alternative Medicine Review : a Journal of Clinical Therapeutic, 7(4), pp. 276-91.
    Patrick L. Nonalcoholic Fatty Liver Disease: Relationship to Insulin Sensitivity and Oxidative Stress. Treatment Approaches Using Vitamin E, Magnesium, and Betaine. Altern Med Rev. 2002;7(4):276-91. PubMed PMID: 12197781.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine. A1 - Patrick,Lyn, PY - 2002/8/29/pubmed PY - 2002/10/19/medline PY - 2002/8/29/entrez SP - 276 EP - 91 JF - Alternative medicine review : a journal of clinical therapeutic JO - Altern Med Rev VL - 7 IS - 4 N2 - Nonalcoholic steatotic hepatitis (NASH), the most prevalent form of progressive liver disease in the United States, is considered to be a manifestation of insulin resistance syndrome. There is increasing evidence that steatosis in NASH is a result of the pathology in fat metabolism occurring in obesity and insulin resistance. For steatosis to progress to necroinflammation and fibrosis, however, the theory of mitochondrial oxidative-stress induced cellular damage is receiving wide acceptance. Treatment approaches that address these etiologies are reviewed: betaine, magnesium, and vitamin E. SN - 1089-5159 UR - https://www.unboundmedicine.com/medline/citation/12197781/full_citation L2 - http://archive.foundationalmedicinereview.com/publications/7/4/276.pdf DB - PRIME DP - Unbound Medicine ER -