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Antibodies to bovine beta-casein in diabetes and other autoimmune diseases.
Horm Metab Res 2002; 34(8):455-9HM

Abstract

Cow's milk is thought to be an environmental trigger for autoimmune response in Type 1 diabetes. In the present study, our aim was to investigate the antibody response to bovine beta-casein in different immune- and non-immune-mediated diseases and to establish whether such an antibody response is specific to Type 1 diabetes. We measured antibodies to bovine beta-casein using an enzyme-linked immunosorbent assay in a total of 519 sera from subjects as follows: 71 patients with Type 1 diabetes, 33 patients with coeliac disease, 100 patients with latent autoimmune diabetes in adults (LADA), 50 patients with autoimmune thyroid disease (ATD), 50 patients with Type 2 diabetes, 24 patients with multiple sclerosis (MS), and 3 different groups of controls (n = 191). Significantly increased levels of antibodies to beta-casein were found in patients with Type 1 diabetes, coeliac disease and in LADA compared to age-matched controls (p = 0.01, p = 0.02 and p = 0.01, respectively). No differences were observed in beta-casein antibody titres between patients with other disease conditions (MS, and ATD) and age-matched controls. The highest antibody response to beta-casein in Type 1 diabetic patients and in patients with coeliac disease could reflect the gut mucosal immune disorders common to Type 1 diabetes and coeliac disease. Furthermore, the elevated beta-casein antibody levels found in LADA patients suggest that the antibody response to this protein may be relevant in autoimmune diabetes.

Authors+Show Affiliations

Unit of Diabetes and Endocrinology, University Campus Bio-Medico, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12198602

Citation

Monetini, L, et al. "Antibodies to Bovine Beta-casein in Diabetes and Other Autoimmune Diseases." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 34, no. 8, 2002, pp. 455-9.
Monetini L, Cavallo MG, Manfrini S, et al. Antibodies to bovine beta-casein in diabetes and other autoimmune diseases. Horm Metab Res. 2002;34(8):455-9.
Monetini, L., Cavallo, M. G., Manfrini, S., Stefanini, L., Picarelli, A., Di Tola, M., ... Pozzilli, P. (2002). Antibodies to bovine beta-casein in diabetes and other autoimmune diseases. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 34(8), pp. 455-9.
Monetini L, et al. Antibodies to Bovine Beta-casein in Diabetes and Other Autoimmune Diseases. Horm Metab Res. 2002;34(8):455-9. PubMed PMID: 12198602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies to bovine beta-casein in diabetes and other autoimmune diseases. AU - Monetini,L, AU - Cavallo,M G, AU - Manfrini,S, AU - Stefanini,L, AU - Picarelli,A, AU - Di Tola,M, AU - Petrone,A, AU - Bianchi,M, AU - La Presa,M, AU - Di Giulio,C, AU - Baroni,M G, AU - Thorpe,R, AU - Walker,B K, AU - Pozzilli,P, AU - ,, PY - 2002/8/29/pubmed PY - 2003/2/8/medline PY - 2002/8/29/entrez SP - 455 EP - 9 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 34 IS - 8 N2 - Cow's milk is thought to be an environmental trigger for autoimmune response in Type 1 diabetes. In the present study, our aim was to investigate the antibody response to bovine beta-casein in different immune- and non-immune-mediated diseases and to establish whether such an antibody response is specific to Type 1 diabetes. We measured antibodies to bovine beta-casein using an enzyme-linked immunosorbent assay in a total of 519 sera from subjects as follows: 71 patients with Type 1 diabetes, 33 patients with coeliac disease, 100 patients with latent autoimmune diabetes in adults (LADA), 50 patients with autoimmune thyroid disease (ATD), 50 patients with Type 2 diabetes, 24 patients with multiple sclerosis (MS), and 3 different groups of controls (n = 191). Significantly increased levels of antibodies to beta-casein were found in patients with Type 1 diabetes, coeliac disease and in LADA compared to age-matched controls (p = 0.01, p = 0.02 and p = 0.01, respectively). No differences were observed in beta-casein antibody titres between patients with other disease conditions (MS, and ATD) and age-matched controls. The highest antibody response to beta-casein in Type 1 diabetic patients and in patients with coeliac disease could reflect the gut mucosal immune disorders common to Type 1 diabetes and coeliac disease. Furthermore, the elevated beta-casein antibody levels found in LADA patients suggest that the antibody response to this protein may be relevant in autoimmune diabetes. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/12198602/full_citation L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-33595 DB - PRIME DP - Unbound Medicine ER -