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Antibodies to bovine beta-casein in diabetes and other autoimmune diseases.

Abstract

Cow's milk is thought to be an environmental trigger for autoimmune response in Type 1 diabetes. In the present study, our aim was to investigate the antibody response to bovine beta-casein in different immune- and non-immune-mediated diseases and to establish whether such an antibody response is specific to Type 1 diabetes. We measured antibodies to bovine beta-casein using an enzyme-linked immunosorbent assay in a total of 519 sera from subjects as follows: 71 patients with Type 1 diabetes, 33 patients with coeliac disease, 100 patients with latent autoimmune diabetes in adults (LADA), 50 patients with autoimmune thyroid disease (ATD), 50 patients with Type 2 diabetes, 24 patients with multiple sclerosis (MS), and 3 different groups of controls (n = 191). Significantly increased levels of antibodies to beta-casein were found in patients with Type 1 diabetes, coeliac disease and in LADA compared to age-matched controls (p = 0.01, p = 0.02 and p = 0.01, respectively). No differences were observed in beta-casein antibody titres between patients with other disease conditions (MS, and ATD) and age-matched controls. The highest antibody response to beta-casein in Type 1 diabetic patients and in patients with coeliac disease could reflect the gut mucosal immune disorders common to Type 1 diabetes and coeliac disease. Furthermore, the elevated beta-casein antibody levels found in LADA patients suggest that the antibody response to this protein may be relevant in autoimmune diabetes.

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  • Authors

    , , , , , , , , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Animals
    Antibodies
    Autoimmune Diseases
    Caseins
    Cattle
    Celiac Disease
    Diabetes Mellitus, Type 1
    Diabetes Mellitus, Type 2
    Female
    Histocompatibility Testing
    Humans
    Immunoglobulin G
    Male
    Middle Aged
    Multiple Sclerosis
    Thyroiditis, Autoimmune

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12198602

    Citation

    TY - JOUR T1 - Antibodies to bovine beta-casein in diabetes and other autoimmune diseases. AU - Monetini,L, AU - Cavallo,M G, AU - Manfrini,S, AU - Stefanini,L, AU - Picarelli,A, AU - Di Tola,M, AU - Petrone,A, AU - Bianchi,M, AU - La Presa,M, AU - Di Giulio,C, AU - Baroni,M G, AU - Thorpe,R, AU - Walker,B K, AU - Pozzilli,P, AU - ,, PY - 2002/8/29/pubmed PY - 2003/2/8/medline PY - 2002/8/29/entrez SP - 455 EP - 9 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme JO - Horm. Metab. Res. VL - 34 IS - 8 N2 - Cow's milk is thought to be an environmental trigger for autoimmune response in Type 1 diabetes. In the present study, our aim was to investigate the antibody response to bovine beta-casein in different immune- and non-immune-mediated diseases and to establish whether such an antibody response is specific to Type 1 diabetes. We measured antibodies to bovine beta-casein using an enzyme-linked immunosorbent assay in a total of 519 sera from subjects as follows: 71 patients with Type 1 diabetes, 33 patients with coeliac disease, 100 patients with latent autoimmune diabetes in adults (LADA), 50 patients with autoimmune thyroid disease (ATD), 50 patients with Type 2 diabetes, 24 patients with multiple sclerosis (MS), and 3 different groups of controls (n = 191). Significantly increased levels of antibodies to beta-casein were found in patients with Type 1 diabetes, coeliac disease and in LADA compared to age-matched controls (p = 0.01, p = 0.02 and p = 0.01, respectively). No differences were observed in beta-casein antibody titres between patients with other disease conditions (MS, and ATD) and age-matched controls. The highest antibody response to beta-casein in Type 1 diabetic patients and in patients with coeliac disease could reflect the gut mucosal immune disorders common to Type 1 diabetes and coeliac disease. Furthermore, the elevated beta-casein antibody levels found in LADA patients suggest that the antibody response to this protein may be relevant in autoimmune diabetes. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/12198602/full_citation L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-33595 ER -