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Ethnic and gender patterns for the five congenital disorders in Texas from 1992 through 1998.

Abstract

The Texas Department of Health's Newborn Screening Program screens for five inherited disorders: phenylketonuria (PKU), congenital adrenal hyperplasia (CAH), congenital hypothyroidism (CH), galactosemia (GAL), and sickle cell disease (SCD). The objective of this study was to determine the prevalence of these disorders and to describe ethnic and gender patterns in their distribution. Cases were identified from blood specimens collected at birth from live births in Texas from 1992 through 1998. During this time, the overall prevalence of these disorders per 10,000 live births was 0.70 for PKU, 0.21 for GAL, 4.18 for CH, 1.03 for CAH, and 3.92 for SCD. Ethnic and gender disparities were observed among PKU, CH, CAH, and SCD prevalence. Results suggest that unidentified mutations and environmental factors may exist that contribute to these patterns. This warrants further investigation to determine possible modifiable risk factors for populations with higher prevalence.

Authors+Show Affiliations

,

University of Texas Medical Branch at Galveston, USA.

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Source

Texas medicine 98:9 2002 Sep pg 80-6

MeSH

Adrenal Hyperplasia, Congenital
Anemia, Sickle Cell
Congenital Hypothyroidism
Female
Galactosemias
Genetic Diseases, Inborn
Humans
Hypothyroidism
Infant, Newborn
Male
Phenylketonurias
Prevalence
Sex Distribution
Texas

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12271912

Citation

TY - JOUR T1 - Ethnic and gender patterns for the five congenital disorders in Texas from 1992 through 1998. AU - Strahan,Jamison E, AU - Canfield,Mark A, AU - Drummond-Borg,L Margaret, AU - Neill,Susan U, PY - 2002/9/26/pubmed PY - 2002/10/17/medline PY - 2002/9/26/entrez SP - 80 EP - 6 JF - Texas medicine JO - Tex Med VL - 98 IS - 9 N2 - The Texas Department of Health's Newborn Screening Program screens for five inherited disorders: phenylketonuria (PKU), congenital adrenal hyperplasia (CAH), congenital hypothyroidism (CH), galactosemia (GAL), and sickle cell disease (SCD). The objective of this study was to determine the prevalence of these disorders and to describe ethnic and gender patterns in their distribution. Cases were identified from blood specimens collected at birth from live births in Texas from 1992 through 1998. During this time, the overall prevalence of these disorders per 10,000 live births was 0.70 for PKU, 0.21 for GAL, 4.18 for CH, 1.03 for CAH, and 3.92 for SCD. Ethnic and gender disparities were observed among PKU, CH, CAH, and SCD prevalence. Results suggest that unidentified mutations and environmental factors may exist that contribute to these patterns. This warrants further investigation to determine possible modifiable risk factors for populations with higher prevalence. SN - 0040-4470 UR - https://www.unboundmedicine.com/medline/citation/12271912/full_citation L2 - http://ghr.nlm.nih.gov/condition=congenital-hypothyroidism ER -