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A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency.

Abstract

AIMS

To determine the prevalence of coeliac disease in a group of patients in the community who have been shown in the laboratory to have iron and/or folate deficiency. To assess the cost efficiency of this laboratory based case finding strategy.

METHODS

The study was undertaken in a large general hospital in the UK serving a population of 300 000. Three hundred and thirty three eligible patients with iron and/or folate deficiency were identified and contacted over an 18 month period. Case finding was by testing for coeliac disease using serological methods and subsequent histological confirmation.

RESULTS

Of the 333 eligible and contactable patients with iron and/or folate deficiency, 258 (77%) consented to coeliac disease antibody testing. Twenty eight patients (10.9%) were positive for coeliac disease antibodies. Of these, 24 patients proceeded to endoscopy and biopsy, resulting in 12 cases of histologically confirmed coeliac disease (4.7% (95% confidence interval, 2.1% to 6.8%) of patients tested for coeliac disease antibodies).

CONCLUSIONS

This laboratory based methodology detected a considerable number of new coeliac disease cases in the community. Many of these patients did not present with clinical findings suggestive of malabsorption and might not otherwise have been diagnosed. Laboratory based methodologies should be considered in conjunction with other strategies for the early identification and treatment of coeliac disease.

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  • Authors+Show Affiliations

    ,

    Department of Haematology, York District Hospital, York YO31 8HE, UK. Martin.R.Howard@excha.yhs-tr.northy.nhs.uk

    , , , ,

    Source

    Journal of clinical pathology 55:10 2002 Oct pg 754-7

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Anemia, Iron-Deficiency
    Autoantibodies
    Celiac Disease
    Female
    Folic Acid Deficiency
    Gliadin
    Humans
    Male
    Middle Aged
    Muscle Fibers, Skeletal
    Prospective Studies

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12354801

    Citation

    Howard, M R., et al. "A Prospective Study of the Prevalence of Undiagnosed Coeliac Disease in Laboratory Defined Iron and Folate Deficiency." Journal of Clinical Pathology, vol. 55, no. 10, 2002, pp. 754-7.
    Howard MR, Turnbull AJ, Morley P, et al. A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency. J Clin Pathol. 2002;55(10):754-7.
    Howard, M. R., Turnbull, A. J., Morley, P., Hollier, P., Webb, R., & Clarke, A. (2002). A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency. Journal of Clinical Pathology, 55(10), pp. 754-7.
    Howard MR, et al. A Prospective Study of the Prevalence of Undiagnosed Coeliac Disease in Laboratory Defined Iron and Folate Deficiency. J Clin Pathol. 2002;55(10):754-7. PubMed PMID: 12354801.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency. AU - Howard,M R, AU - Turnbull,A J, AU - Morley,P, AU - Hollier,P, AU - Webb,R, AU - Clarke,A, PY - 2002/10/2/pubmed PY - 2002/11/26/medline PY - 2002/10/2/entrez SP - 754 EP - 7 JF - Journal of clinical pathology JO - J. Clin. Pathol. VL - 55 IS - 10 N2 - AIMS: To determine the prevalence of coeliac disease in a group of patients in the community who have been shown in the laboratory to have iron and/or folate deficiency. To assess the cost efficiency of this laboratory based case finding strategy. METHODS: The study was undertaken in a large general hospital in the UK serving a population of 300 000. Three hundred and thirty three eligible patients with iron and/or folate deficiency were identified and contacted over an 18 month period. Case finding was by testing for coeliac disease using serological methods and subsequent histological confirmation. RESULTS: Of the 333 eligible and contactable patients with iron and/or folate deficiency, 258 (77%) consented to coeliac disease antibody testing. Twenty eight patients (10.9%) were positive for coeliac disease antibodies. Of these, 24 patients proceeded to endoscopy and biopsy, resulting in 12 cases of histologically confirmed coeliac disease (4.7% (95% confidence interval, 2.1% to 6.8%) of patients tested for coeliac disease antibodies). CONCLUSIONS: This laboratory based methodology detected a considerable number of new coeliac disease cases in the community. Many of these patients did not present with clinical findings suggestive of malabsorption and might not otherwise have been diagnosed. Laboratory based methodologies should be considered in conjunction with other strategies for the early identification and treatment of coeliac disease. SN - 0021-9746 UR - https://www.unboundmedicine.com/medline/citation/12354801/full_citation L2 - http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=12354801 DB - PRIME DP - Unbound Medicine ER -