Type your tag names separated by a space and hit enter

Dietary weight loss decreases serum angiotensin-converting enzyme activity in obese adults.

Abstract

OBJECTIVE

To study the effect of dietary weight loss, postural change, and an oral glucose load on serum angiotensin-converting enzyme (ACE) activity in obese adults.

RESEARCH METHODS AND PROCEDURES

Sixteen obese adult men and women with a mean body mass index of 35.7 +/- 4.3 kg/m(2) were studied after 1 week on a maintenance energy lead-in diet and after 5 weeks on an identical but 40% reduced-energy diet provided by the General Clinical Research Center (GCRC). ACE activity was measured spectrophotometrically. Plasma renin activity and serum aldosterone were measured by radioimmunoassay.

RESULTS

All subjects lost weight, with a mean decrease in body weight of 7.0 +/- 2.1 kg or 6 +/- 3% of initial body weight (p < 0.00001). Systolic and diastolic blood pressure, supine plasma renin activity, and serum aldosterone levels decreased with weight loss (p < 0.05). Supine ACE activity decreased 23 +/- 12% with weight loss (p < 0.00001). Standing ACE activity, which was significantly higher than supine ACE activity before and after weight loss (p < 0.05), also decreased 18 +/- 17% with weight loss (p = 0.0007). A 75-g oral glucose load had no effect on serum ACE activity over a 3-hour period.

DISCUSSION

In obese adults, serum ACE activity declines with modest weight loss, increases with postural change, and is unaffected by an oral glucose load.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. jharp@unc.edu

    ,

    Source

    Obesity research 10:10 2002 Oct pg 985-90

    MeSH

    Adult
    Aldosterone
    Basal Metabolism
    Blood Glucose
    Blood Pressure
    Body Mass Index
    Calorimetry
    Diet, Reducing
    Female
    Humans
    Insulin
    Male
    Middle Aged
    Obesity
    Peptidyl-Dipeptidase A
    Posture
    Renin
    Statistics, Nonparametric
    Weight Loss

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12376578

    Citation

    Harp, Joyce B., et al. "Dietary Weight Loss Decreases Serum Angiotensin-converting Enzyme Activity in Obese Adults." Obesity Research, vol. 10, no. 10, 2002, pp. 985-90.
    Harp JB, Henry SA, DiGirolamo M. Dietary weight loss decreases serum angiotensin-converting enzyme activity in obese adults. Obes Res. 2002;10(10):985-90.
    Harp, J. B., Henry, S. A., & DiGirolamo, M. (2002). Dietary weight loss decreases serum angiotensin-converting enzyme activity in obese adults. Obesity Research, 10(10), pp. 985-90.
    Harp JB, Henry SA, DiGirolamo M. Dietary Weight Loss Decreases Serum Angiotensin-converting Enzyme Activity in Obese Adults. Obes Res. 2002;10(10):985-90. PubMed PMID: 12376578.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary weight loss decreases serum angiotensin-converting enzyme activity in obese adults. AU - Harp,Joyce B, AU - Henry,Steven A, AU - DiGirolamo,Mario, PY - 2002/10/12/pubmed PY - 2003/1/22/medline PY - 2002/10/12/entrez SP - 985 EP - 90 JF - Obesity research JO - Obes. Res. VL - 10 IS - 10 N2 - OBJECTIVE: To study the effect of dietary weight loss, postural change, and an oral glucose load on serum angiotensin-converting enzyme (ACE) activity in obese adults. RESEARCH METHODS AND PROCEDURES: Sixteen obese adult men and women with a mean body mass index of 35.7 +/- 4.3 kg/m(2) were studied after 1 week on a maintenance energy lead-in diet and after 5 weeks on an identical but 40% reduced-energy diet provided by the General Clinical Research Center (GCRC). ACE activity was measured spectrophotometrically. Plasma renin activity and serum aldosterone were measured by radioimmunoassay. RESULTS: All subjects lost weight, with a mean decrease in body weight of 7.0 +/- 2.1 kg or 6 +/- 3% of initial body weight (p < 0.00001). Systolic and diastolic blood pressure, supine plasma renin activity, and serum aldosterone levels decreased with weight loss (p < 0.05). Supine ACE activity decreased 23 +/- 12% with weight loss (p < 0.00001). Standing ACE activity, which was significantly higher than supine ACE activity before and after weight loss (p < 0.05), also decreased 18 +/- 17% with weight loss (p = 0.0007). A 75-g oral glucose load had no effect on serum ACE activity over a 3-hour period. DISCUSSION: In obese adults, serum ACE activity declines with modest weight loss, increases with postural change, and is unaffected by an oral glucose load. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12376578/full_citation L2 - https://doi.org/10.1038/oby.2002.134 DB - PRIME DP - Unbound Medicine ER -