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The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria.

Abstract

The purpose of this study was to determine the fatty acid composition of the serum phospholipids of children with sickle cell disease (SCD) in Nigeria and to compare the relative fluidity of the acyl chains of the serum phospholipids of controls versus the subjects with SCD. It is widely accepted that the fatty acid composition of an individual's serum phospholipids reflects that of their tissue phospholipids. An alteration in the fatty acid composition of membrane phospholipids could affect critical membrane-dependent enzymes and processes (e.g., ion and solute transport, hormone-receptor interactions, signal transduction pathways). We found a significant reduction in the content of polyunsaturated n-3 fatty acids in the phospholipids of subjects with SCD which could result in a reduction of the fluidity of their tissue membranes. Specifically, there was a 40-50% reduction in the proportion of total n-3 fatty acids in subjects with SCD. On the basis of calculated melting points and double bond indices of the acyl chains of the serum phospholipids, the phospholipids of the children with SCD are less fluid relative to those of their healthy counterparts. In addition, we determined that linoleic acid, arachidonic acid, and stearic acid were the major determinants of the fluidity of the acyl chains of the serum phospholipids of the healthy controls and children with SCD.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.

    , , ,

    Source

    MeSH

    Adolescent
    Anemia, Sickle Cell
    Case-Control Studies
    Child
    Child, Preschool
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids
    Fatty Acids, Unsaturated
    Female
    Humans
    Male
    Nigeria
    Phospholipids
    Sex Factors
    Temperature

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12401435

    Citation

    TY - JOUR T1 - The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. AU - Glew,R H, AU - Casados,J K, AU - Huang,Y-S, AU - Chuang,L-T, AU - VanderJagt,D J, PY - 2002/10/29/pubmed PY - 2003/8/23/medline PY - 2002/10/29/entrez SP - 217 EP - 22 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 67 IS - 4 N2 - The purpose of this study was to determine the fatty acid composition of the serum phospholipids of children with sickle cell disease (SCD) in Nigeria and to compare the relative fluidity of the acyl chains of the serum phospholipids of controls versus the subjects with SCD. It is widely accepted that the fatty acid composition of an individual's serum phospholipids reflects that of their tissue phospholipids. An alteration in the fatty acid composition of membrane phospholipids could affect critical membrane-dependent enzymes and processes (e.g., ion and solute transport, hormone-receptor interactions, signal transduction pathways). We found a significant reduction in the content of polyunsaturated n-3 fatty acids in the phospholipids of subjects with SCD which could result in a reduction of the fluidity of their tissue membranes. Specifically, there was a 40-50% reduction in the proportion of total n-3 fatty acids in subjects with SCD. On the basis of calculated melting points and double bond indices of the acyl chains of the serum phospholipids, the phospholipids of the children with SCD are less fluid relative to those of their healthy counterparts. In addition, we determined that linoleic acid, arachidonic acid, and stearic acid were the major determinants of the fluidity of the acyl chains of the serum phospholipids of the healthy controls and children with SCD. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/12401435/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S0952327802904230 ER -