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Fasting glucose is a risk factor for breast cancer: a prospective study.

Abstract

There is some evidence that glucose and other factors related to glucose metabolism, such as insulin and insulin-like growth-factors (IGFs) may contribute to breast cancer development. The present study analyzed the hypothesis that serum glucose, insulin levels, and IGF-I pattern are associated with breast cancer using a nested case-control study. Between 1987 and 1992, 10,786 women ages 35-69 were recruited in a prospective study in Italy. Women with history of cancer and on hormone therapy were excluded at baseline. At recruitment, blood samples were collected after a 12-h fast between 7:30 and 9:00 a.m. from all of the study participants. After 5.5 years, 144 breast cancer cases were identified among the participants of the cohort. Four matched controls were chosen for each breast cancer case from members of the cohort who did not develop breast cancer during the follow-up period. In premenopausal women, glucose was associated with breast cancer risk: the age, body mass index, and reproductive variable adjusted relative risk (RR) for the highest quartile of serum glucose versus the lowest was 2.8 [95% confidence interval (CI), 1.2-6.5], and P for trend was 0.02. Insulin showed a weaker association with breast cancer, the adjusted RR of the highest quartile versus the lowest was 1.7 (95% CI, 0.7-4.1), and P for trend was 0.14, whereas the adjusted RR of the highest quartile of IGF-I was 3.1 (95% CI, 1.1-8.6), and P for trend was 0.01. Increased levels of insulin-like growth factor binding protein-3 (IGFBP)-3 were related to breast cancer risk: the adjusted RR for the highest quartile was 2.1 (95% CI, 0.95-4.75), and P for trend was 0.02. In postmenopausal women, the associations of glucose, insulin, and IGF-1 pattern were associated with breast cancer risk in heavier subjects characterized by a body mass index higher than 26. These results indicate that chronic alteration of glucose metabolism is related to breast cancer development.

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  • Authors+Show Affiliations

    ,

    Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo 14214, USA.

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    Source

    MeSH

    Adult
    Age Factors
    Aged
    Biomarkers, Tumor
    Blood Glucose
    Body Constitution
    Body Mass Index
    Breast Neoplasms
    Case-Control Studies
    Cohort Studies
    Fasting
    Female
    Follow-Up Studies
    Humans
    Incidence
    Insulin
    Insulin-Like Growth Factor Binding Proteins
    Insulin-Like Growth Factor I
    Italy
    Menopause
    Middle Aged
    Observer Variation
    Prospective Studies
    Risk Factors
    Women's Health

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Controlled Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    12433712

    Citation

    Muti, Paola, et al. "Fasting Glucose Is a Risk Factor for Breast Cancer: a Prospective Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 11, no. 11, 2002, pp. 1361-8.
    Muti P, Quattrin T, Grant BJ, et al. Fasting glucose is a risk factor for breast cancer: a prospective study. Cancer Epidemiol Biomarkers Prev. 2002;11(11):1361-8.
    Muti, P., Quattrin, T., Grant, B. J., Krogh, V., Micheli, A., Schünemann, H. J., ... Berrino, F. (2002). Fasting glucose is a risk factor for breast cancer: a prospective study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 11(11), pp. 1361-8.
    Muti P, et al. Fasting Glucose Is a Risk Factor for Breast Cancer: a Prospective Study. Cancer Epidemiol Biomarkers Prev. 2002;11(11):1361-8. PubMed PMID: 12433712.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fasting glucose is a risk factor for breast cancer: a prospective study. AU - Muti,Paola, AU - Quattrin,Teresa, AU - Grant,Brydon J B, AU - Krogh,Vittorio, AU - Micheli,Andrea, AU - Schünemann,Holger J, AU - Ram,Malathi, AU - Freudenheim,Jo L, AU - Sieri,Sabina, AU - Trevisan,Maurizio, AU - Berrino,Franco, PY - 2002/11/16/pubmed PY - 2003/3/8/medline PY - 2002/11/16/entrez SP - 1361 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 11 IS - 11 N2 - There is some evidence that glucose and other factors related to glucose metabolism, such as insulin and insulin-like growth-factors (IGFs) may contribute to breast cancer development. The present study analyzed the hypothesis that serum glucose, insulin levels, and IGF-I pattern are associated with breast cancer using a nested case-control study. Between 1987 and 1992, 10,786 women ages 35-69 were recruited in a prospective study in Italy. Women with history of cancer and on hormone therapy were excluded at baseline. At recruitment, blood samples were collected after a 12-h fast between 7:30 and 9:00 a.m. from all of the study participants. After 5.5 years, 144 breast cancer cases were identified among the participants of the cohort. Four matched controls were chosen for each breast cancer case from members of the cohort who did not develop breast cancer during the follow-up period. In premenopausal women, glucose was associated with breast cancer risk: the age, body mass index, and reproductive variable adjusted relative risk (RR) for the highest quartile of serum glucose versus the lowest was 2.8 [95% confidence interval (CI), 1.2-6.5], and P for trend was 0.02. Insulin showed a weaker association with breast cancer, the adjusted RR of the highest quartile versus the lowest was 1.7 (95% CI, 0.7-4.1), and P for trend was 0.14, whereas the adjusted RR of the highest quartile of IGF-I was 3.1 (95% CI, 1.1-8.6), and P for trend was 0.01. Increased levels of insulin-like growth factor binding protein-3 (IGFBP)-3 were related to breast cancer risk: the adjusted RR for the highest quartile was 2.1 (95% CI, 0.95-4.75), and P for trend was 0.02. In postmenopausal women, the associations of glucose, insulin, and IGF-1 pattern were associated with breast cancer risk in heavier subjects characterized by a body mass index higher than 26. These results indicate that chronic alteration of glucose metabolism is related to breast cancer development. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12433712/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12433712 DB - PRIME DP - Unbound Medicine ER -