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The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans.
Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1441-8.CE

Abstract

The lower rates of some cancers in Asian countries than in Western countries may be partly because of diet, although the mechanisms are unknown. The aim of this cross-sectional study was to determine whether a plant-based (vegan) diet is associated with a lower circulating level of insulin-like growth factor I (IGF-I) compared with a meat-eating or lacto-ovo-vegetarian diet among 292 British women, ages 20-70 years. The mean serum IGF-I concentration was 13% lower in 92 vegan women compared with 99 meat-eaters and 101 vegetarians (P = 0.0006). The mean concentrations of both serum IGF-binding protein (IGFBP)-1 and IGFBP-2 were 20-40% higher in vegan women compared with meat-eaters and vegetarians (P = 0.005 and P = 0.0008 for IGFBP-1 and IGFBP-2, respectively). There were no significant differences in IGFBP-3, C-peptide, or sex hormone-binding globulin concentrations between the diet groups. Intake of protein rich in essential amino acids was positively associated with serum IGF-I (Pearson partial correlation coefficient; r = 0.27; P < 0.0001) and explained most of the differences in IGF-I concentration between the diet groups. These data suggest that a plant-based diet is associated with lower circulating levels of total IGF-I and higher levels of IGFBP-1 and IGFBP-2.

Authors+Show Affiliations

Allen NE
Cancer Research United Kingdom Epidemiology Unit, University of Oxford, Oxford OX2 6HE, United Kingdom. naomi.allen@cancer.org.uk
Appleby PN
No affiliation info available
Davey GK
No affiliation info available
Kaaks R
No affiliation info available
Rinaldi S
No affiliation info available
Key TJ
No affiliation info available

MeSH

AdultAgedAnimalsBiomarkersBody Mass IndexC-PeptideCircadian RhythmCross-Sectional StudiesDairy ProductsDiet, VegetarianEatingFemaleHumansInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IMeatMiddle AgedPlantsSex Hormone-Binding GlobulinStatistics as TopicTime FactorsUnited KingdomWomen's HealthZinc

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12433724

Clinical Trial Links

Hypoproteic Diet in Acromegaly

Citation

Allen, Naomi E., et al. "The Associations of Diet With Serum Insulin-like Growth Factor I and Its Main Binding Proteins in 292 Women Meat-eaters, Vegetarians, and Vegans." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 11, no. 11, 2002, pp. 1441-8.
Allen NE, Appleby PN, Davey GK, et al. The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. Cancer Epidemiol Biomarkers Prev. 2002;11(11):1441-8.
Allen, N. E., Appleby, P. N., Davey, G. K., Kaaks, R., Rinaldi, S., & Key, T. J. (2002). The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 11(11), 1441-8.
Allen NE, et al. The Associations of Diet With Serum Insulin-like Growth Factor I and Its Main Binding Proteins in 292 Women Meat-eaters, Vegetarians, and Vegans. Cancer Epidemiol Biomarkers Prev. 2002;11(11):1441-8. PubMed PMID: 12433724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. AU - Allen,Naomi E, AU - Appleby,Paul N, AU - Davey,Gwyneth K, AU - Kaaks,Rudolf, AU - Rinaldi,Sabina, AU - Key,Timothy J, PY - 2002/11/16/pubmed PY - 2003/3/8/medline PY - 2002/11/16/entrez SP - 1441 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 11 IS - 11 N2 - The lower rates of some cancers in Asian countries than in Western countries may be partly because of diet, although the mechanisms are unknown. The aim of this cross-sectional study was to determine whether a plant-based (vegan) diet is associated with a lower circulating level of insulin-like growth factor I (IGF-I) compared with a meat-eating or lacto-ovo-vegetarian diet among 292 British women, ages 20-70 years. The mean serum IGF-I concentration was 13% lower in 92 vegan women compared with 99 meat-eaters and 101 vegetarians (P = 0.0006). The mean concentrations of both serum IGF-binding protein (IGFBP)-1 and IGFBP-2 were 20-40% higher in vegan women compared with meat-eaters and vegetarians (P = 0.005 and P = 0.0008 for IGFBP-1 and IGFBP-2, respectively). There were no significant differences in IGFBP-3, C-peptide, or sex hormone-binding globulin concentrations between the diet groups. Intake of protein rich in essential amino acids was positively associated with serum IGF-I (Pearson partial correlation coefficient; r = 0.27; P < 0.0001) and explained most of the differences in IGF-I concentration between the diet groups. These data suggest that a plant-based diet is associated with lower circulating levels of total IGF-I and higher levels of IGFBP-1 and IGFBP-2. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12433724/full_citation DB - PRIME DP - Unbound Medicine ER -