Tags

Type your tag names separated by a space and hit enter

Serum antioxidant vitamins and blood pressure in the United States population.
Hypertension 2002; 40(6):810-6H

Abstract

Serum vitamin C has been inversely associated with blood pressure in several epidemiologic studies, but little is known about effect of other antioxidant vitamins. We examined the relation between serum vitamins A, C, and E, alpha-carotene, and beta-carotene levels and blood pressure among 15 317 men and women > or =20 years of age who participated in the Third National Health and Nutrition Examination Survey. Blood pressure was characterized as the average of 6 measurements obtained over 2 visits by trained observers and hypertension was defined as blood pressure > or =140/90 mm Hg and/or taking antihypertensive medications. In multivariate models, a 1 SD difference in vitamin A (16.2 microg/dL) and vitamin E (20.4 microg/dL) was associated with a 43% (OR, 1.43; 95% CI, 1.34 to 1.53) and 18% (OR, 1.18; 95% CI, 1.09 to 1.27) higher odds of hypertension, respectively. A 1 SD difference in alpha-carotene (0.47 micro g/dL) and beta-carotene (496 microg/dL) was associated with a 16% (OR, 0.84; 95% CI, 0.76 to 0.94) and 11% (OR, 0.89; 95% CI, 0.82 to 0.97) lower odds of hypertension, respectively. In addition, serum vitamins A and E were positively and significantly associated with both systolic and diastolic blood pressure, whereas alpha-carotene and beta-carotene were inversely and significantly associated with systolic and vitamin C associated with diastolic blood pressure in multivariate linear regression analyses. These findings indicate that antioxidant vitamins may be important in the underlying cause and prevention of hypertension. Further studies in this important area are warranted.

Authors+Show Affiliations

Department of Medicine, Tulane University School of Medicine, New Orleans, La, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12468562

Citation

Chen, Jing, et al. "Serum Antioxidant Vitamins and Blood Pressure in the United States Population." Hypertension (Dallas, Tex. : 1979), vol. 40, no. 6, 2002, pp. 810-6.
Chen J, He J, Hamm L, et al. Serum antioxidant vitamins and blood pressure in the United States population. Hypertension. 2002;40(6):810-6.
Chen, J., He, J., Hamm, L., Batuman, V., & Whelton, P. K. (2002). Serum antioxidant vitamins and blood pressure in the United States population. Hypertension (Dallas, Tex. : 1979), 40(6), pp. 810-6.
Chen J, et al. Serum Antioxidant Vitamins and Blood Pressure in the United States Population. Hypertension. 2002;40(6):810-6. PubMed PMID: 12468562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum antioxidant vitamins and blood pressure in the United States population. AU - Chen,Jing, AU - He,Jiang, AU - Hamm,Lee, AU - Batuman,Vecihi, AU - Whelton,Paul K, PY - 2002/12/7/pubmed PY - 2003/1/24/medline PY - 2002/12/7/entrez SP - 810 EP - 6 JF - Hypertension (Dallas, Tex. : 1979) JO - Hypertension VL - 40 IS - 6 N2 - Serum vitamin C has been inversely associated with blood pressure in several epidemiologic studies, but little is known about effect of other antioxidant vitamins. We examined the relation between serum vitamins A, C, and E, alpha-carotene, and beta-carotene levels and blood pressure among 15 317 men and women > or =20 years of age who participated in the Third National Health and Nutrition Examination Survey. Blood pressure was characterized as the average of 6 measurements obtained over 2 visits by trained observers and hypertension was defined as blood pressure > or =140/90 mm Hg and/or taking antihypertensive medications. In multivariate models, a 1 SD difference in vitamin A (16.2 microg/dL) and vitamin E (20.4 microg/dL) was associated with a 43% (OR, 1.43; 95% CI, 1.34 to 1.53) and 18% (OR, 1.18; 95% CI, 1.09 to 1.27) higher odds of hypertension, respectively. A 1 SD difference in alpha-carotene (0.47 micro g/dL) and beta-carotene (496 microg/dL) was associated with a 16% (OR, 0.84; 95% CI, 0.76 to 0.94) and 11% (OR, 0.89; 95% CI, 0.82 to 0.97) lower odds of hypertension, respectively. In addition, serum vitamins A and E were positively and significantly associated with both systolic and diastolic blood pressure, whereas alpha-carotene and beta-carotene were inversely and significantly associated with systolic and vitamin C associated with diastolic blood pressure in multivariate linear regression analyses. These findings indicate that antioxidant vitamins may be important in the underlying cause and prevention of hypertension. Further studies in this important area are warranted. SN - 1524-4563 UR - https://www.unboundmedicine.com/medline/citation/12468562/full_citation L2 - http://www.ahajournals.org/doi/full/10.1161/01.hyp.0000039962.68332.59?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -