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Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging.

Abstract

OBJECTIVE

To investigate the association between prostate cancer and calcium and other nutrients thought to influence the synthesis of 1,25-dihydroxyvitamin D [1,25(OH)2D].

METHODS

We included in the analysis 454 male participants in the Baltimore Longitudinal Study of Aging who were 46 to 92 years old at the time of completion of a food frequency questionnaire. Among them, 69 men were diagnosed with prostate cancer during their lifetime. In 68% of the cases, the food frequency questionnaire was completed after the diagnosis of cancer. Multiple logistic regression analysis was used to calculate the odds ratio and 95% confidence interval of prostate cancer.

RESULTS

The median calcium intake was 788 mg/day. The adjusted odds ratio of prostate cancer for the highest tertile compared with the lowest tertile of calcium intake was 0.92 (95% confidence interval 0.48 to 1.77; P(trend) = 0.89). Likewise, no significant trends were found for phosphorus, vitamin D, fructose, or animal protein intake. Dairy products, including milk, were not associated with an increased risk of prostate cancer. The adjusted odds ratio of prostate cancer was 1.26 (95% confidence interval 0.57 to 2.79; P(trend) = 0.73) for men with high dairy intakes compared with those with low dairy intakes.

CONCLUSIONS

The results of this study suggest that calcium intake within moderate limits is not associated with a notably increased risk of prostate cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

    , , , , , ,

    Source

    Urology 60:6 2002 Dec pg 1118-23

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Animals
    Calcium, Dietary
    Confidence Intervals
    Dairy Products
    Feeding Behavior
    Humans
    Longitudinal Studies
    Male
    Middle Aged
    Milk
    Odds Ratio
    Phosphorus
    Prostatic Neoplasms
    Risk
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12475694

    Citation

    Berndt, Sonja I., et al. "Calcium Intake and Prostate Cancer Risk in a Long-term Aging Study: the Baltimore Longitudinal Study of Aging." Urology, vol. 60, no. 6, 2002, pp. 1118-23.
    Berndt SI, Carter HB, Landis PK, et al. Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging. Urology. 2002;60(6):1118-23.
    Berndt, S. I., Carter, H. B., Landis, P. K., Tucker, K. L., Hsieh, L. J., Metter, E. J., & Platz, E. A. (2002). Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging. Urology, 60(6), pp. 1118-23.
    Berndt SI, et al. Calcium Intake and Prostate Cancer Risk in a Long-term Aging Study: the Baltimore Longitudinal Study of Aging. Urology. 2002;60(6):1118-23. PubMed PMID: 12475694.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging. AU - Berndt,Sonja I, AU - Carter,H Ballentine, AU - Landis,Patricia K, AU - Tucker,Katherine L, AU - Hsieh,Lillian J, AU - Metter,E Jeffrey, AU - Platz,Elizabeth A, AU - ,, PY - 2002/12/12/pubmed PY - 2003/1/17/medline PY - 2002/12/12/entrez SP - 1118 EP - 23 JF - Urology JO - Urology VL - 60 IS - 6 N2 - OBJECTIVE: To investigate the association between prostate cancer and calcium and other nutrients thought to influence the synthesis of 1,25-dihydroxyvitamin D [1,25(OH)2D]. METHODS: We included in the analysis 454 male participants in the Baltimore Longitudinal Study of Aging who were 46 to 92 years old at the time of completion of a food frequency questionnaire. Among them, 69 men were diagnosed with prostate cancer during their lifetime. In 68% of the cases, the food frequency questionnaire was completed after the diagnosis of cancer. Multiple logistic regression analysis was used to calculate the odds ratio and 95% confidence interval of prostate cancer. RESULTS: The median calcium intake was 788 mg/day. The adjusted odds ratio of prostate cancer for the highest tertile compared with the lowest tertile of calcium intake was 0.92 (95% confidence interval 0.48 to 1.77; P(trend) = 0.89). Likewise, no significant trends were found for phosphorus, vitamin D, fructose, or animal protein intake. Dairy products, including milk, were not associated with an increased risk of prostate cancer. The adjusted odds ratio of prostate cancer was 1.26 (95% confidence interval 0.57 to 2.79; P(trend) = 0.73) for men with high dairy intakes compared with those with low dairy intakes. CONCLUSIONS: The results of this study suggest that calcium intake within moderate limits is not associated with a notably increased risk of prostate cancer. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/12475694/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S009042950201991X DB - PRIME DP - Unbound Medicine ER -