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The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health.
Thyroid 2002; 12(10):867-78T

Abstract

Several minerals and trace elements are essential for normal thyroid hormone metabolism, e.g., iodine, iron, selenium, and zinc. Coexisting deficiencies of these elements can impair thyroid function. Iron deficiency impairs thyroid hormone synthesis by reducing activity of heme-dependent thyroid peroxidase. Iron-deficiency anemia blunts and iron supplementation improves the efficacy of iodine supplementation. Combined selenium and iodine deficiency leads to myxedematous cretinism. The normal thyroid gland retains high selenium concentrations even under conditions of inadequate selenium supply and expresses many of the known selenocysteine-containing proteins. Among these selenoproteins are the glutathione peroxidase, deiodinase, and thioredoxine reductase families of enzymes. Adequate selenium nutrition supports efficient thyroid hormone synthesis and metabolism and protects the thyroid gland from damage by excessive iodide exposure. In regions of combined severe iodine and selenium deficiency, normalization of iodine supply is mandatory before initiation of selenium supplementation in order to prevent hypothyroidism. Selenium deficiency and disturbed thyroid hormone economy may develop under conditions of special dietary regimens such as long-term total parenteral nutrition, phenylketonuria diet, cystic fibrosis, or may be the result of imbalanced nutrition in children, elderly people, or sick patients.

Authors+Show Affiliations

Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zürich, Switzerland. Michael.zimmermann@ilw.agrt.ethz.chNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12487769

Citation

Zimmermann, Michael B., and Josef Köhrle. "The Impact of Iron and Selenium Deficiencies On Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health." Thyroid : Official Journal of the American Thyroid Association, vol. 12, no. 10, 2002, pp. 867-78.
Zimmermann MB, Köhrle J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid. 2002;12(10):867-78.
Zimmermann, M. B., & Köhrle, J. (2002). The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid : Official Journal of the American Thyroid Association, 12(10), pp. 867-78.
Zimmermann MB, Köhrle J. The Impact of Iron and Selenium Deficiencies On Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health. Thyroid. 2002;12(10):867-78. PubMed PMID: 12487769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. AU - Zimmermann,Michael B, AU - Köhrle,Josef, PY - 2002/12/19/pubmed PY - 2003/5/13/medline PY - 2002/12/19/entrez SP - 867 EP - 78 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 12 IS - 10 N2 - Several minerals and trace elements are essential for normal thyroid hormone metabolism, e.g., iodine, iron, selenium, and zinc. Coexisting deficiencies of these elements can impair thyroid function. Iron deficiency impairs thyroid hormone synthesis by reducing activity of heme-dependent thyroid peroxidase. Iron-deficiency anemia blunts and iron supplementation improves the efficacy of iodine supplementation. Combined selenium and iodine deficiency leads to myxedematous cretinism. The normal thyroid gland retains high selenium concentrations even under conditions of inadequate selenium supply and expresses many of the known selenocysteine-containing proteins. Among these selenoproteins are the glutathione peroxidase, deiodinase, and thioredoxine reductase families of enzymes. Adequate selenium nutrition supports efficient thyroid hormone synthesis and metabolism and protects the thyroid gland from damage by excessive iodide exposure. In regions of combined severe iodine and selenium deficiency, normalization of iodine supply is mandatory before initiation of selenium supplementation in order to prevent hypothyroidism. Selenium deficiency and disturbed thyroid hormone economy may develop under conditions of special dietary regimens such as long-term total parenteral nutrition, phenylketonuria diet, cystic fibrosis, or may be the result of imbalanced nutrition in children, elderly people, or sick patients. SN - 1050-7256 UR - https://www.unboundmedicine.com/medline/citation/12487769/full_citation L2 - https://www.liebertpub.com/doi/full/10.1089/105072502761016494?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -