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Epidemiology of perforated colonic diverticular disease.

Abstract

Perforated colonic diverticular disease results in considerable mortality and morbidity. This review appraises existing evidence on the epidemiology and mechanisms of perforation, highlights areas of further study, and suggests an epidemiological approach towards preventing the condition. Computerised searches were used to identify published articles relating to the epidemiology, pathophysiology, and clinical features of perforated colonic diverticular disease. Several drug and dietary exposures have potential biological mechanisms for causing perforation. Of these only non-steroidal anti-inflammatory drugs have been consistently identified as risk factors in aetiological studies. The causes of perforated colonic diverticular disease remain largely unknown. Further aetiological studies, looking specifically at perforation, are required to investigate whether cause-effect relationships exist for both drug and dietary exposures. The identification of risk factors for perforation would allow primary public health prevention, secondary risk factor modification, and early prophylactic surgery to be aimed at people at high risk.

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  • Authors+Show Affiliations

    ,

    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK. christopher.morris@uea.ac.uk

    , , , ,

    Source

    Postgraduate medical journal 78:925 2002 Nov pg 654-8

    MeSH

    Alcohol Drinking
    Anti-Inflammatory Agents, Non-Steroidal
    Diet
    Diverticulitis, Colonic
    Global Health
    Humans
    Incidence
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    12496319

    Citation

    Morris, C R., et al. "Epidemiology of Perforated Colonic Diverticular Disease." Postgraduate Medical Journal, vol. 78, no. 925, 2002, pp. 654-8.
    Morris CR, Harvey IM, Stebbings WS, et al. Epidemiology of perforated colonic diverticular disease. Postgrad Med J. 2002;78(925):654-8.
    Morris, C. R., Harvey, I. M., Stebbings, W. S., Speakman, C. T., Kennedy, H. J., & Hart, A. R. (2002). Epidemiology of perforated colonic diverticular disease. Postgraduate Medical Journal, 78(925), pp. 654-8.
    Morris CR, et al. Epidemiology of Perforated Colonic Diverticular Disease. Postgrad Med J. 2002;78(925):654-8. PubMed PMID: 12496319.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiology of perforated colonic diverticular disease. AU - Morris,C R, AU - Harvey,I M, AU - Stebbings,W S L, AU - Speakman,C T M, AU - Kennedy,H J, AU - Hart,A R, PY - 2002/12/24/pubmed PY - 2003/3/4/medline PY - 2002/12/24/entrez SP - 654 EP - 8 JF - Postgraduate medical journal JO - Postgrad Med J VL - 78 IS - 925 N2 - Perforated colonic diverticular disease results in considerable mortality and morbidity. This review appraises existing evidence on the epidemiology and mechanisms of perforation, highlights areas of further study, and suggests an epidemiological approach towards preventing the condition. Computerised searches were used to identify published articles relating to the epidemiology, pathophysiology, and clinical features of perforated colonic diverticular disease. Several drug and dietary exposures have potential biological mechanisms for causing perforation. Of these only non-steroidal anti-inflammatory drugs have been consistently identified as risk factors in aetiological studies. The causes of perforated colonic diverticular disease remain largely unknown. Further aetiological studies, looking specifically at perforation, are required to investigate whether cause-effect relationships exist for both drug and dietary exposures. The identification of risk factors for perforation would allow primary public health prevention, secondary risk factor modification, and early prophylactic surgery to be aimed at people at high risk. SN - 0032-5473 UR - https://www.unboundmedicine.com/medline/citation/12496319/full_citation L2 - http://pmj.bmj.com/cgi/pmidlookup?view=long&pmid=12496319 DB - PRIME DP - Unbound Medicine ER -