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Epidemiology of perforated colonic diverticular disease.
Postgrad Med J 2002; 78(925):654-8PM

Abstract

Perforated colonic diverticular disease results in considerable mortality and morbidity. This review appraises existing evidence on the epidemiology and mechanisms of perforation, highlights areas of further study, and suggests an epidemiological approach towards preventing the condition. Computerised searches were used to identify published articles relating to the epidemiology, pathophysiology, and clinical features of perforated colonic diverticular disease. Several drug and dietary exposures have potential biological mechanisms for causing perforation. Of these only non-steroidal anti-inflammatory drugs have been consistently identified as risk factors in aetiological studies. The causes of perforated colonic diverticular disease remain largely unknown. Further aetiological studies, looking specifically at perforation, are required to investigate whether cause-effect relationships exist for both drug and dietary exposures. The identification of risk factors for perforation would allow primary public health prevention, secondary risk factor modification, and early prophylactic surgery to be aimed at people at high risk.

Authors+Show Affiliations

School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK. christopher.morris@uea.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12496319

Citation

Morris, C R., et al. "Epidemiology of Perforated Colonic Diverticular Disease." Postgraduate Medical Journal, vol. 78, no. 925, 2002, pp. 654-8.
Morris CR, Harvey IM, Stebbings WS, et al. Epidemiology of perforated colonic diverticular disease. Postgrad Med J. 2002;78(925):654-8.
Morris, C. R., Harvey, I. M., Stebbings, W. S., Speakman, C. T., Kennedy, H. J., & Hart, A. R. (2002). Epidemiology of perforated colonic diverticular disease. Postgraduate Medical Journal, 78(925), pp. 654-8.
Morris CR, et al. Epidemiology of Perforated Colonic Diverticular Disease. Postgrad Med J. 2002;78(925):654-8. PubMed PMID: 12496319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of perforated colonic diverticular disease. AU - Morris,C R, AU - Harvey,I M, AU - Stebbings,W S L, AU - Speakman,C T M, AU - Kennedy,H J, AU - Hart,A R, PY - 2002/12/24/pubmed PY - 2003/3/4/medline PY - 2002/12/24/entrez SP - 654 EP - 8 JF - Postgraduate medical journal JO - Postgrad Med J VL - 78 IS - 925 N2 - Perforated colonic diverticular disease results in considerable mortality and morbidity. This review appraises existing evidence on the epidemiology and mechanisms of perforation, highlights areas of further study, and suggests an epidemiological approach towards preventing the condition. Computerised searches were used to identify published articles relating to the epidemiology, pathophysiology, and clinical features of perforated colonic diverticular disease. Several drug and dietary exposures have potential biological mechanisms for causing perforation. Of these only non-steroidal anti-inflammatory drugs have been consistently identified as risk factors in aetiological studies. The causes of perforated colonic diverticular disease remain largely unknown. Further aetiological studies, looking specifically at perforation, are required to investigate whether cause-effect relationships exist for both drug and dietary exposures. The identification of risk factors for perforation would allow primary public health prevention, secondary risk factor modification, and early prophylactic surgery to be aimed at people at high risk. SN - 0032-5473 UR - https://www.unboundmedicine.com/medline/citation/12496319/full_citation L2 - http://pmj.bmj.com/cgi/pmidlookup?view=long&pmid=12496319 DB - PRIME DP - Unbound Medicine ER -