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Immunization and MS [RETIRED]: a summary of published evidence and recommendations.
Neurology. 2002 Dec 24; 59(12):1837-43.Neur

Abstract

OBJECTIVE

To review the risk of MS exacerbations after infectious episodes potentially preventable by vaccination, and the risks and benefits of immunizing patients with MS.

METHODS

The authors searched MEDLINE (1966 to January 2001; U.S. National Library of Medicine, Bethesda, MD), HealthSTAR, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) database (Cinahl Information Systems, Glendale, CA) for English-language articles. Each study was summarized and rated for quality of evidence. Then feasible data were pooled and analyzed in meta-analysis.

RESULTS

The risk of contracting common infectious diseases in patients with MS is not well established. There is strong evidence for an increased risk of MS exacerbations during weeks around an infectious episode. There is strong evidence against an increased risk of MS exacerbation after influenza immunization. There is no evidence that hepatitis B, varicella, tetanus, or Bacille Calmette-Guerin vaccines increase the risk of MS exacerbations. Insufficient evidence was found for other vaccines.

CONCLUSIONS

Evidence supports 1) strategies to minimize the risk of acquiring infectious diseases that may trigger exacerbations of MS; and 2) the safety of using influenza, hepatitis B, varicella, tetanus, and Bacille Calmette-Guerin (BCG) vaccines in patients with MS.

Authors+Show Affiliations

Rutschmann OT
Duke Center for Clinical Health Policy Research, Duke University Medical Center, Durham, NC, USA.
McCrory DC
No affiliation info available
Matchar DB
No affiliation info available
Immunization Panel of the Multiple Sclerosis Council for Clinical Practice Guidelines
No affiliation info available

MeSH

Communicable Disease ControlHumansInfectionsMultiple SclerosisVaccinationVaccines

Pub Type(s)

Guideline
Journal Article
Meta-Analysis

Language

eng

PubMed ID

12499473

Clinical Trial Links

Immunisation Status and Safety of Vaccines in Italian MS Patients

Citation

Rutschmann, Olivier T., et al. "Immunization and MS [RETIRED]: a Summary of Published Evidence and Recommendations." Neurology, vol. 59, no. 12, 2002, pp. 1837-43.
Rutschmann OT, McCrory DC, Matchar DB, et al. Immunization and MS [RETIRED]: a summary of published evidence and recommendations. Neurology. 2002;59(12):1837-43.
Rutschmann, O. T., McCrory, D. C., & Matchar, D. B. (2002). Immunization and MS [RETIRED]: a summary of published evidence and recommendations. Neurology, 59(12), 1837-43.
Rutschmann OT, et al. Immunization and MS [RETIRED]: a Summary of Published Evidence and Recommendations. Neurology. 2002 12 24;59(12):1837-43. PubMed PMID: 12499473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunization and MS [RETIRED]: a summary of published evidence and recommendations. AU - Rutschmann,Olivier T, AU - McCrory,Douglas C, AU - Matchar,David B, AU - ,, PY - 2002/12/25/pubmed PY - 2003/1/15/medline PY - 2002/12/25/entrez SP - 1837 EP - 43 JF - Neurology JO - Neurology VL - 59 IS - 12 N2 - OBJECTIVE: To review the risk of MS exacerbations after infectious episodes potentially preventable by vaccination, and the risks and benefits of immunizing patients with MS. METHODS: The authors searched MEDLINE (1966 to January 2001; U.S. National Library of Medicine, Bethesda, MD), HealthSTAR, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) database (Cinahl Information Systems, Glendale, CA) for English-language articles. Each study was summarized and rated for quality of evidence. Then feasible data were pooled and analyzed in meta-analysis. RESULTS: The risk of contracting common infectious diseases in patients with MS is not well established. There is strong evidence for an increased risk of MS exacerbations during weeks around an infectious episode. There is strong evidence against an increased risk of MS exacerbation after influenza immunization. There is no evidence that hepatitis B, varicella, tetanus, or Bacille Calmette-Guerin vaccines increase the risk of MS exacerbations. Insufficient evidence was found for other vaccines. CONCLUSIONS: Evidence supports 1) strategies to minimize the risk of acquiring infectious diseases that may trigger exacerbations of MS; and 2) the safety of using influenza, hepatitis B, varicella, tetanus, and Bacille Calmette-Guerin (BCG) vaccines in patients with MS. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/12499473/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓28]

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