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Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults.

Abstract

BACKGROUND

Previous studies suggest that zinc salts may be effective in treating the common cold. Since rhinovirus infections occur primarily in the nasal cavity, an attempt to arrest the infection at the portal of entry seems logical.

AIM

To assess the ability of zinc nasal gel to shorten the duration and reduce the severity of the common cold in healthy adults.

STUDY DESIGN

Randomized, double blind, placebo-controlled study.

METHODS

Of 1087 patients screened by telephone, 80 patients were enrolled, all presenting within 24-48 h of the onset of illness. They received one dose per nostril of a nasal gel spray containing either 33 mmol/l zincum gluconicum, or an identical placebo four times daily until their symptoms resolved, for a maximum of 10 days.

RESULTS

Median duration of cold symptoms in the zinc group was significantly shorter than in the placebo group (median [IQR] 4.3 days [2.5-5.5] vs. 6 days [5-8.5], p=0.002). Nasal drainage, nasal congestion, hoarseness, and sore throat were the symptoms most affected. Significant reduction of total symptom scores started from the second day of the study. Adverse effects (mainly nasal stinging) were similar in both groups.

DISCUSSION

Zincum gluconicum nasal gel shortens duration and reduces symptom severity of the common cold in healthy adults, when started within 24-48 h of the onset of illness.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Infectious Diseases, S-32, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. mossads@ccf.org

    Source

    MeSH

    Administration, Intranasal
    Adult
    Common Cold
    Double-Blind Method
    Female
    Gels
    Gluconates
    Humans
    Male
    Patient Compliance
    Time Factors
    Treatment Outcome
    Zinc

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12509647

    Citation

    Mossad, S B.. "Effect of Zincum Gluconicum Nasal Gel On the Duration and Symptom Severity of the Common Cold in Otherwise Healthy Adults." QJM : Monthly Journal of the Association of Physicians, vol. 96, no. 1, 2003, pp. 35-43.
    Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM. 2003;96(1):35-43.
    Mossad, S. B. (2003). Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM : Monthly Journal of the Association of Physicians, 96(1), pp. 35-43.
    Mossad SB. Effect of Zincum Gluconicum Nasal Gel On the Duration and Symptom Severity of the Common Cold in Otherwise Healthy Adults. QJM. 2003;96(1):35-43. PubMed PMID: 12509647.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. A1 - Mossad,S B, PY - 2003/1/2/pubmed PY - 2003/2/26/medline PY - 2003/1/2/entrez SP - 35 EP - 43 JF - QJM : monthly journal of the Association of Physicians JO - QJM VL - 96 IS - 1 N2 - BACKGROUND: Previous studies suggest that zinc salts may be effective in treating the common cold. Since rhinovirus infections occur primarily in the nasal cavity, an attempt to arrest the infection at the portal of entry seems logical. AIM: To assess the ability of zinc nasal gel to shorten the duration and reduce the severity of the common cold in healthy adults. STUDY DESIGN: Randomized, double blind, placebo-controlled study. METHODS: Of 1087 patients screened by telephone, 80 patients were enrolled, all presenting within 24-48 h of the onset of illness. They received one dose per nostril of a nasal gel spray containing either 33 mmol/l zincum gluconicum, or an identical placebo four times daily until their symptoms resolved, for a maximum of 10 days. RESULTS: Median duration of cold symptoms in the zinc group was significantly shorter than in the placebo group (median [IQR] 4.3 days [2.5-5.5] vs. 6 days [5-8.5], p=0.002). Nasal drainage, nasal congestion, hoarseness, and sore throat were the symptoms most affected. Significant reduction of total symptom scores started from the second day of the study. Adverse effects (mainly nasal stinging) were similar in both groups. DISCUSSION: Zincum gluconicum nasal gel shortens duration and reduces symptom severity of the common cold in healthy adults, when started within 24-48 h of the onset of illness. SN - 1460-2725 UR - https://www.unboundmedicine.com/medline/citation/12509647/full_citation L2 - https://academic.oup.com/qjmed/article-lookup/doi/10.1093/qjmed/hcg004 DB - PRIME DP - Unbound Medicine ER -