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Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort.

Abstract

Since high energy intake, inactivity, hypertension and diabetes are linked to obesity and an unfavorable hormonal profile, we wanted to test whether energy intake, physical activity, blood pressure and serum glucose are related to the risk of endometrial cancer independent of the body mass index (BMI). A cohort of 24,460 women, aged 20-49 years, attended a Norwegian health screening twice during 1974-1981; they answered questions about diet, physical activity and chronic diseases, and their height, weight, blood pressure and non-fasting serum glucose were measured. By the end of 1996, during 15.7 years of follow-up, 130 cases of endometrial carcinomas were identified. The relative risks (RRs) for endometrial cancer were estimated in proportional hazards models including potentially confounding factors. Obese women (BMI > or = 30 kg/m(2)) were at 2.6 times increased risk of endometrial cancer compared to normal weight women (BMI < 25 kg/m(2)) (RR = 2.57, 95%CI = 1.61-4.10). Among overweight women (BMI > or = 25 kg/m(2)), non-fasting serum glucose in the upper quartile vs. in the lower quartile was associated with a 2.4 times increase in risk (RR = 2.41, 95%CI = 1.08-5.37), whereas among obese women, blood pressure above 140/90 mmHg vs. below 140/90 mmHg in both surveys was associated with a 3.5 times increase in risk (RR = 3.47, 95%CI = 1.24-9.70). Especially in women younger than 50 years, high energy intake (5,044-6,401 kJ/day) conferred higher risk compared to low energy intake (< 4266 kJ/day) (RR = 3.40, 95%CI = 1.52-7.60). Increasing recreational activity tended to be protective. Among obese women with non-sedentary jobs at both screenings, RR declined to 0.18 (95%CI = 0.05-0.62) as the level of sustained occupational activity increased (p(trend) = 0.03). Our results suggest that inactivity and high energy intake are major risk factors for endometrial cancer independent of BMI, and that hypertension and relative hyperglycemia are significant markers of risk, especially among the heaviest women.

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  • Authors+Show Affiliations

    ,

    Institute of Community Medicine, Faculty of Medicine, University of Tromsø, Tromsø, Norway. anne.sofie.furberg@ism.uit.no

    Source

    International journal of cancer 104:6 2003 May 10 pg 669-76

    MeSH

    Adult
    Blood Pressure
    Body Height
    Body Mass Index
    Body Weight
    Cohort Studies
    Endometrial Neoplasms
    Energy Intake
    Exercise
    Female
    Follow-Up Studies
    Humans
    Hyperglycemia
    Hypertension
    Life Style
    Middle Aged
    Norway
    Obesity
    Registries
    Risk Factors
    Smoking
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12640672

    Citation

    Furberg, Anne-Sofie, and Inger Thune. "Metabolic Abnormalities (hypertension, Hyperglycemia and Overweight), Lifestyle (high Energy Intake and Physical Inactivity) and Endometrial Cancer Risk in a Norwegian Cohort." International Journal of Cancer, vol. 104, no. 6, 2003, pp. 669-76.
    Furberg AS, Thune I. Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. Int J Cancer. 2003;104(6):669-76.
    Furberg, A. S., & Thune, I. (2003). Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. International Journal of Cancer, 104(6), pp. 669-76.
    Furberg AS, Thune I. Metabolic Abnormalities (hypertension, Hyperglycemia and Overweight), Lifestyle (high Energy Intake and Physical Inactivity) and Endometrial Cancer Risk in a Norwegian Cohort. Int J Cancer. 2003 May 10;104(6):669-76. PubMed PMID: 12640672.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. AU - Furberg,Anne-Sofie, AU - Thune,Inger, PY - 2003/3/18/pubmed PY - 2003/5/13/medline PY - 2003/3/18/entrez SP - 669 EP - 76 JF - International journal of cancer JO - Int. J. Cancer VL - 104 IS - 6 N2 - Since high energy intake, inactivity, hypertension and diabetes are linked to obesity and an unfavorable hormonal profile, we wanted to test whether energy intake, physical activity, blood pressure and serum glucose are related to the risk of endometrial cancer independent of the body mass index (BMI). A cohort of 24,460 women, aged 20-49 years, attended a Norwegian health screening twice during 1974-1981; they answered questions about diet, physical activity and chronic diseases, and their height, weight, blood pressure and non-fasting serum glucose were measured. By the end of 1996, during 15.7 years of follow-up, 130 cases of endometrial carcinomas were identified. The relative risks (RRs) for endometrial cancer were estimated in proportional hazards models including potentially confounding factors. Obese women (BMI > or = 30 kg/m(2)) were at 2.6 times increased risk of endometrial cancer compared to normal weight women (BMI < 25 kg/m(2)) (RR = 2.57, 95%CI = 1.61-4.10). Among overweight women (BMI > or = 25 kg/m(2)), non-fasting serum glucose in the upper quartile vs. in the lower quartile was associated with a 2.4 times increase in risk (RR = 2.41, 95%CI = 1.08-5.37), whereas among obese women, blood pressure above 140/90 mmHg vs. below 140/90 mmHg in both surveys was associated with a 3.5 times increase in risk (RR = 3.47, 95%CI = 1.24-9.70). Especially in women younger than 50 years, high energy intake (5,044-6,401 kJ/day) conferred higher risk compared to low energy intake (< 4266 kJ/day) (RR = 3.40, 95%CI = 1.52-7.60). Increasing recreational activity tended to be protective. Among obese women with non-sedentary jobs at both screenings, RR declined to 0.18 (95%CI = 0.05-0.62) as the level of sustained occupational activity increased (p(trend) = 0.03). Our results suggest that inactivity and high energy intake are major risk factors for endometrial cancer independent of BMI, and that hypertension and relative hyperglycemia are significant markers of risk, especially among the heaviest women. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/12640672/full_citation L2 - https://doi.org/10.1002/ijc.10974 DB - PRIME DP - Unbound Medicine ER -