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Antitumor effect of vitamin B6 and its mechanisms.
Biochim Biophys Acta 2003; 1647(1-2):127-30BB

Abstract

Epidemiological studies have reported an inverse association between vitamin B(6) intake and colon cancer risk. Our recent study has been conducted to examine the effect of dietary vitamin B(6) on colon tumorigenesis in mice. Mice were fed diets containing 1, 7, 14 or 36 mg/kg pyridoxine for 22 weeks, and given a weekly injection of azoxymethane (AOM) for the initial 10 weeks. Compared with the 1 mg/kg pyridoxine diet, 7, 14 and 35 mg/kg pyridoxine diets significantly suppressed the incidence and number of colon tumors, colon cell proliferation and expressions of c-myc and c-fos proteins. Supplemental vitamin B(6) lowered the levels of colonic 8-hydroxyguanosine (8-OHdG), 4-hydroxy-2-nonenal (4-HNE, oxidative stress markers) and inducible nitric oxide (NO) synthase protein. In an ex vivo serum-free matrix culture model using rat aortic ring, supplemental pyridoxine and pyridoxal 5'-phosphate (PLP) had antiangiogenic effect. The results suggest that dietary vitamin B(6) suppresses colon tumorigenesis by reducing cell proliferation, oxidative stress, NO production and angiogenesis.

Authors+Show Affiliations

Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima 739-8528, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12686121

Citation

Komatsu, S, et al. "Antitumor Effect of Vitamin B6 and Its Mechanisms." Biochimica Et Biophysica Acta, vol. 1647, no. 1-2, 2003, pp. 127-30.
Komatsu S, Yanaka N, Matsubara K, et al. Antitumor effect of vitamin B6 and its mechanisms. Biochim Biophys Acta. 2003;1647(1-2):127-30.
Komatsu, S., Yanaka, N., Matsubara, K., & Kato, N. (2003). Antitumor effect of vitamin B6 and its mechanisms. Biochimica Et Biophysica Acta, 1647(1-2), pp. 127-30.
Komatsu S, et al. Antitumor Effect of Vitamin B6 and Its Mechanisms. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):127-30. PubMed PMID: 12686121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor effect of vitamin B6 and its mechanisms. AU - Komatsu,S, AU - Yanaka,N, AU - Matsubara,K, AU - Kato,N, PY - 2003/4/11/pubmed PY - 2003/6/6/medline PY - 2003/4/11/entrez SP - 127 EP - 30 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1647 IS - 1-2 N2 - Epidemiological studies have reported an inverse association between vitamin B(6) intake and colon cancer risk. Our recent study has been conducted to examine the effect of dietary vitamin B(6) on colon tumorigenesis in mice. Mice were fed diets containing 1, 7, 14 or 36 mg/kg pyridoxine for 22 weeks, and given a weekly injection of azoxymethane (AOM) for the initial 10 weeks. Compared with the 1 mg/kg pyridoxine diet, 7, 14 and 35 mg/kg pyridoxine diets significantly suppressed the incidence and number of colon tumors, colon cell proliferation and expressions of c-myc and c-fos proteins. Supplemental vitamin B(6) lowered the levels of colonic 8-hydroxyguanosine (8-OHdG), 4-hydroxy-2-nonenal (4-HNE, oxidative stress markers) and inducible nitric oxide (NO) synthase protein. In an ex vivo serum-free matrix culture model using rat aortic ring, supplemental pyridoxine and pyridoxal 5'-phosphate (PLP) had antiangiogenic effect. The results suggest that dietary vitamin B(6) suppresses colon tumorigenesis by reducing cell proliferation, oxidative stress, NO production and angiogenesis. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/12686121/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570963903000761 DB - PRIME DP - Unbound Medicine ER -