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Platelet activation and endothelial cell dysfunction in sickle cell disease is unrelated to reduced antioxidant capacity.
Blood Coagul Fibrinolysis 2003; 14(3):255-9BC

Abstract

Possible pathogenetic processes in sickle cell disease include antioxidants, endothelial and platelet changes, and hypercoagulability. Hypothesizing relationships between these processes, we recruited 47 young adult patients (mean age 19 years) with homozygous sickle cell disease and 40 age-, race- and sex-matched healthy controls and measured plasma markers representative of these processes. We found raised plasma von Willebrand factor (P = 0.001) and intercellular adhesion molecule (P = 0.016, both marking endothelial perturbation, but the latter also marking inflammation), raised soluble P selectin (P = 0.002) (marking platelet activation) and inflammation marker C reactive protein (P = 0.021), but reduced antioxidant capacity (P = 0.002) in patients compared with controls. There was no difference in fibrinogen and there was no significant correlation between any of the indices. Our data suggest that changes in endothelial and platelet function in sickle cell disease are unrelated to reduced antioxidant capacity.

Authors+Show Affiliations

Department of Haematology, City Hospital, Birmingham B18 7QH, UK. a.blann@bham.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12695748

Citation

Blann, Andrew D., et al. "Platelet Activation and Endothelial Cell Dysfunction in Sickle Cell Disease Is Unrelated to Reduced Antioxidant Capacity." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 14, no. 3, 2003, pp. 255-9.
Blann AD, Marwah S, Serjeant G, et al. Platelet activation and endothelial cell dysfunction in sickle cell disease is unrelated to reduced antioxidant capacity. Blood Coagul Fibrinolysis. 2003;14(3):255-9.
Blann, A. D., Marwah, S., Serjeant, G., Bareford, D., & Wright, J. (2003). Platelet activation and endothelial cell dysfunction in sickle cell disease is unrelated to reduced antioxidant capacity. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 14(3), pp. 255-9.
Blann AD, et al. Platelet Activation and Endothelial Cell Dysfunction in Sickle Cell Disease Is Unrelated to Reduced Antioxidant Capacity. Blood Coagul Fibrinolysis. 2003;14(3):255-9. PubMed PMID: 12695748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet activation and endothelial cell dysfunction in sickle cell disease is unrelated to reduced antioxidant capacity. AU - Blann,Andrew D, AU - Marwah,Sukhjinder, AU - Serjeant,Graham, AU - Bareford,David, AU - Wright,Josh, PY - 2003/4/16/pubmed PY - 2004/4/21/medline PY - 2003/4/16/entrez SP - 255 EP - 9 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 14 IS - 3 N2 - Possible pathogenetic processes in sickle cell disease include antioxidants, endothelial and platelet changes, and hypercoagulability. Hypothesizing relationships between these processes, we recruited 47 young adult patients (mean age 19 years) with homozygous sickle cell disease and 40 age-, race- and sex-matched healthy controls and measured plasma markers representative of these processes. We found raised plasma von Willebrand factor (P = 0.001) and intercellular adhesion molecule (P = 0.016, both marking endothelial perturbation, but the latter also marking inflammation), raised soluble P selectin (P = 0.002) (marking platelet activation) and inflammation marker C reactive protein (P = 0.021), but reduced antioxidant capacity (P = 0.002) in patients compared with controls. There was no difference in fibrinogen and there was no significant correlation between any of the indices. Our data suggest that changes in endothelial and platelet function in sickle cell disease are unrelated to reduced antioxidant capacity. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/12695748/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=12695748 DB - PRIME DP - Unbound Medicine ER -