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Platelet activation and endothelial cell dysfunction in sickle cell disease is unrelated to reduced antioxidant capacity.

Abstract

Possible pathogenetic processes in sickle cell disease include antioxidants, endothelial and platelet changes, and hypercoagulability. Hypothesizing relationships between these processes, we recruited 47 young adult patients (mean age 19 years) with homozygous sickle cell disease and 40 age-, race- and sex-matched healthy controls and measured plasma markers representative of these processes. We found raised plasma von Willebrand factor (P = 0.001) and intercellular adhesion molecule (P = 0.016, both marking endothelial perturbation, but the latter also marking inflammation), raised soluble P selectin (P = 0.002) (marking platelet activation) and inflammation marker C reactive protein (P = 0.021), but reduced antioxidant capacity (P = 0.002) in patients compared with controls. There was no difference in fibrinogen and there was no significant correlation between any of the indices. Our data suggest that changes in endothelial and platelet function in sickle cell disease are unrelated to reduced antioxidant capacity.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Haematology, City Hospital, Birmingham B18 7QH, UK. a.blann@bham.ac.uk

    , , ,

    Source

    MeSH

    Acute-Phase Reaction
    Adult
    Anemia, Sickle Cell
    Antioxidants
    Biomarkers
    C-Reactive Protein
    Case-Control Studies
    Cross-Sectional Studies
    Endothelial Cells
    Female
    Fibrinogen
    Humans
    Intercellular Adhesion Molecule-1
    Male
    P-Selectin
    Platelet Activation
    von Willebrand Factor

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12695748

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Platelet activation and endothelial cell dysfunction in sickle cell disease is unrelated to reduced antioxidant capacity. AU - Blann,Andrew D, AU - Marwah,Sukhjinder, AU - Serjeant,Graham, AU - Bareford,David, AU - Wright,Josh, PY - 2003/4/16/pubmed PY - 2004/4/21/medline PY - 2003/4/16/entrez SP - 255 EP - 9 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 14 IS - 3 N2 - Possible pathogenetic processes in sickle cell disease include antioxidants, endothelial and platelet changes, and hypercoagulability. Hypothesizing relationships between these processes, we recruited 47 young adult patients (mean age 19 years) with homozygous sickle cell disease and 40 age-, race- and sex-matched healthy controls and measured plasma markers representative of these processes. We found raised plasma von Willebrand factor (P = 0.001) and intercellular adhesion molecule (P = 0.016, both marking endothelial perturbation, but the latter also marking inflammation), raised soluble P selectin (P = 0.002) (marking platelet activation) and inflammation marker C reactive protein (P = 0.021), but reduced antioxidant capacity (P = 0.002) in patients compared with controls. There was no difference in fibrinogen and there was no significant correlation between any of the indices. Our data suggest that changes in endothelial and platelet function in sickle cell disease are unrelated to reduced antioxidant capacity. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/12695748/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=12695748 DB - PRIME DP - Unbound Medicine ER -