Tags

Type your tag names separated by a space and hit enter

Treatment of chronic constipation with colchicine: randomized, double-blind, placebo-controlled, crossover trial.

Abstract

OBJECTIVE

Refractory constipation is a common GI complaint seen by physicians in all practice settings. We have previously shown that p.d. colchicine (0.6 mg t.i.d.) increases the number of spontaneous bowel movements, hastens GI transit, and improves GI symptoms in patients with chronic constipation during an 8-wk, open-label therapeutic trial. The aim of this study was to determine if p.d. colchicine will increase spontaneous bowel movements and accelerate colonic transit in patients with idiopathic chronic constipation in a randomized, placebo-controlled, crossover trial.

METHODS

A total of 16 patients (15 women, one man) with a mean age of 47 yr (age range 25-89) with chronic idiopathic constipation who were refractory to standard medical therapy participated in the study. Patients randomly received either colchicine 0.6 mg p.o. t.i.d. or an identical placebo p.o. t.i.d. for a total of 4 wk in a double-blind, crossover fashion. Patients recorded their daily number of bowel movements and daily symptoms of daily nausea, abdominal pain, and bloating. Mean colonic transit was calculated at baseline, weeks 6 and 12.

RESULTS

Colchicine increased the number of bowel movements and accelerated colonic transit compared with baseline and placebo conditions. There were no significant differences between conditions on ratings of nausea and bloating. During colchicine administration, mean abdominal pain was greater than the baseline or placebo conditions, however, the pain decreased significantly by the last week the patient was on colchicine.

CONCLUSION

Colchicine increases the frequency of bowel movements and hastens colonic transit in patients with chronic constipation. Colchicine may be an effective agent available to practitioners to treat a subset of patients with chronic constipation who are refractory to standard medical therapy.

Links

  • Publisher Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA.

    , , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Analysis of Variance
    Chronic Disease
    Colchicine
    Colon
    Constipation
    Cross-Over Studies
    Double-Blind Method
    Female
    Humans
    Male
    Middle Aged
    Placebo Effect
    Prospective Studies

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12809836

    Citation

    Verne, G Nicholas, et al. "Treatment of Chronic Constipation With Colchicine: Randomized, Double-blind, Placebo-controlled, Crossover Trial." The American Journal of Gastroenterology, vol. 98, no. 5, 2003, pp. 1112-6.
    Verne GN, Davis RH, Robinson ME, et al. Treatment of chronic constipation with colchicine: randomized, double-blind, placebo-controlled, crossover trial. Am J Gastroenterol. 2003;98(5):1112-6.
    Verne, G. N., Davis, R. H., Robinson, M. E., Gordon, J. M., Eaker, E. Y., & Sninksy, C. A. (2003). Treatment of chronic constipation with colchicine: randomized, double-blind, placebo-controlled, crossover trial. The American Journal of Gastroenterology, 98(5), pp. 1112-6.
    Verne GN, et al. Treatment of Chronic Constipation With Colchicine: Randomized, Double-blind, Placebo-controlled, Crossover Trial. Am J Gastroenterol. 2003;98(5):1112-6. PubMed PMID: 12809836.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Treatment of chronic constipation with colchicine: randomized, double-blind, placebo-controlled, crossover trial. AU - Verne,G Nicholas, AU - Davis,Richard H, AU - Robinson,Michael E, AU - Gordon,James M, AU - Eaker,Ervin Y, AU - Sninksy,Charles A, PY - 2003/6/18/pubmed PY - 2003/7/25/medline PY - 2003/6/18/entrez SP - 1112 EP - 6 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 98 IS - 5 N2 - OBJECTIVE: Refractory constipation is a common GI complaint seen by physicians in all practice settings. We have previously shown that p.d. colchicine (0.6 mg t.i.d.) increases the number of spontaneous bowel movements, hastens GI transit, and improves GI symptoms in patients with chronic constipation during an 8-wk, open-label therapeutic trial. The aim of this study was to determine if p.d. colchicine will increase spontaneous bowel movements and accelerate colonic transit in patients with idiopathic chronic constipation in a randomized, placebo-controlled, crossover trial. METHODS: A total of 16 patients (15 women, one man) with a mean age of 47 yr (age range 25-89) with chronic idiopathic constipation who were refractory to standard medical therapy participated in the study. Patients randomly received either colchicine 0.6 mg p.o. t.i.d. or an identical placebo p.o. t.i.d. for a total of 4 wk in a double-blind, crossover fashion. Patients recorded their daily number of bowel movements and daily symptoms of daily nausea, abdominal pain, and bloating. Mean colonic transit was calculated at baseline, weeks 6 and 12. RESULTS: Colchicine increased the number of bowel movements and accelerated colonic transit compared with baseline and placebo conditions. There were no significant differences between conditions on ratings of nausea and bloating. During colchicine administration, mean abdominal pain was greater than the baseline or placebo conditions, however, the pain decreased significantly by the last week the patient was on colchicine. CONCLUSION: Colchicine increases the frequency of bowel movements and hastens colonic transit in patients with chronic constipation. Colchicine may be an effective agent available to practitioners to treat a subset of patients with chronic constipation who are refractory to standard medical therapy. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12809836/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-9270&date=2003&volume=98&issue=5&spage=1112 DB - PRIME DP - Unbound Medicine ER -