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Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study.
BMJ 2003; 327(7410):316BMJ

Abstract

OBJECTIVE

To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis.

DESIGN

Population based case-control study.

SETTING

Tasmania, latitudes 41-3 degrees S.

PARTICIPANTS

136 cases with multiple sclerosis and 272 controls randomly drawn from the community and matched on sex and year of birth.

MAIN OUTCOME MEASURE

Multiple sclerosis defined by both clinical and magnetic resonance imaging criteria.

RESULTS

Higher sun exposure when aged 6-15 years (average 2-3 hours or more a day in summer during weekends and holidays) was associated with a decreased risk of multiple sclerosis (adjusted odds ratio 0.31, 95% confidence interval 0.16 to 0.59). Higher exposure in winter seemed more important than higher exposure in summer. Greater actinic damage was also independently associated with a decreased risk of multiple sclerosis (0.32, 0.11 to 0.88 for grades 4-6 disease). A dose-response relation was observed between multiple sclerosis and decreasing sun exposure when aged 6-15 years and with actinic damage.

CONCLUSION

Higher sun exposure during childhood and early adolescence is associated with a reduced risk of multiple sclerosis. Insufficient ultraviolet radiation may therefore influence the development of multiple sclerosis.

Authors+Show Affiliations

Menzies Centre for Population Health Research, University of Tasmania, Hobart, TAS 7000, Australia. Ingrid.vanderMei@utas.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12907484

Citation

van der Mei, I A F., et al. "Past Exposure to Sun, Skin Phenotype, and Risk of Multiple Sclerosis: Case-control Study." BMJ (Clinical Research Ed.), vol. 327, no. 7410, 2003, p. 316.
van der Mei IA, Ponsonby AL, Dwyer T, et al. Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ. 2003;327(7410):316.
van der Mei, I. A., Ponsonby, A. L., Dwyer, T., Blizzard, L., Simmons, R., Taylor, B. V., ... Kilpatrick, T. (2003). Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ (Clinical Research Ed.), 327(7410), p. 316.
van der Mei IA, et al. Past Exposure to Sun, Skin Phenotype, and Risk of Multiple Sclerosis: Case-control Study. BMJ. 2003 Aug 9;327(7410):316. PubMed PMID: 12907484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. AU - van der Mei,I A F, AU - Ponsonby,A-L, AU - Dwyer,T, AU - Blizzard,L, AU - Simmons,R, AU - Taylor,B V, AU - Butzkueven,H, AU - Kilpatrick,T, PY - 2003/8/9/pubmed PY - 2003/8/26/medline PY - 2003/8/9/entrez SP - 316 EP - 316 JF - BMJ (Clinical research ed.) JO - BMJ VL - 327 IS - 7410 N2 - OBJECTIVE: To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis. DESIGN: Population based case-control study. SETTING: Tasmania, latitudes 41-3 degrees S. PARTICIPANTS: 136 cases with multiple sclerosis and 272 controls randomly drawn from the community and matched on sex and year of birth. MAIN OUTCOME MEASURE: Multiple sclerosis defined by both clinical and magnetic resonance imaging criteria. RESULTS: Higher sun exposure when aged 6-15 years (average 2-3 hours or more a day in summer during weekends and holidays) was associated with a decreased risk of multiple sclerosis (adjusted odds ratio 0.31, 95% confidence interval 0.16 to 0.59). Higher exposure in winter seemed more important than higher exposure in summer. Greater actinic damage was also independently associated with a decreased risk of multiple sclerosis (0.32, 0.11 to 0.88 for grades 4-6 disease). A dose-response relation was observed between multiple sclerosis and decreasing sun exposure when aged 6-15 years and with actinic damage. CONCLUSION: Higher sun exposure during childhood and early adolescence is associated with a reduced risk of multiple sclerosis. Insufficient ultraviolet radiation may therefore influence the development of multiple sclerosis. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/12907484/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=12907484 DB - PRIME DP - Unbound Medicine ER -