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The association between gout and nephrolithiasis in men: The Health Professionals' Follow-Up Study.
Kidney Int 2003; 64(3):1022-6KI

Abstract

Approximately 10 million adults in the United States have experienced the passage of a kidney stone, and up to 5 million have been diagnosed with gout by a physician. Previous reports have suggested that gout increases the risk for the development of kidney stones, but there are no prospective data. We used data from a cohort of 51,529 male health care professionals to examine the independent association between gout and kidney stone disease. In a cross-sectional analysis of gout and kidney stone disease reported on the 1986 baseline questionnaire, the prevalence of kidney stone disease was almost twofold higher in men with history of gout compared to those without (15% vs. 8%). After adjusting for age and body mass index (BMI), a history of gout remained significantly associated with kidney stone disease (OR 1.88; 95% CI 1.68 to 2.11). We then prospectively examined the risk of incident kidney stones in men with and without a confirmed diagnosis of gout after excluding men who reported a history of kidney stone disease or gout on the baseline questionnaire. A confirmed diagnosis of gout increased the multivariate relative risk of incident kidney stones (RR 2.12; 95% CI 1.22 to 3.68). In contrast, a history of kidney stone disease was not associated with increased risk of gout (RR 1.05; 95% CI 0.54 to 2.07). In conclusion, a history of gout independently increases the risk for incident kidney stones in men. Physicians should provide dietary counseling, such as increasing fluid intake and decreasing salt consumption, to subjects with gout in addition to other risk factors, such as family history of kidney stones, in order to decrease the likelihood of stone formation.

Authors+Show Affiliations

Department of Preventive Medicine and Epidemiology, Division of Nephrology, Loyola University Medical Center, Maywood, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12911552

Citation

Kramer, Holly J., et al. "The Association Between Gout and Nephrolithiasis in Men: the Health Professionals' Follow-Up Study." Kidney International, vol. 64, no. 3, 2003, pp. 1022-6.
Kramer HJ, Choi HK, Atkinson K, et al. The association between gout and nephrolithiasis in men: The Health Professionals' Follow-Up Study. Kidney Int. 2003;64(3):1022-6.
Kramer, H. J., Choi, H. K., Atkinson, K., Stampfer, M., & Curhan, G. C. (2003). The association between gout and nephrolithiasis in men: The Health Professionals' Follow-Up Study. Kidney International, 64(3), pp. 1022-6.
Kramer HJ, et al. The Association Between Gout and Nephrolithiasis in Men: the Health Professionals' Follow-Up Study. Kidney Int. 2003;64(3):1022-6. PubMed PMID: 12911552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between gout and nephrolithiasis in men: The Health Professionals' Follow-Up Study. AU - Kramer,Holly J, AU - Choi,Hyon K, AU - Atkinson,Karen, AU - Stampfer,Meir, AU - Curhan,Gary C, PY - 2003/8/13/pubmed PY - 2004/4/15/medline PY - 2003/8/13/entrez SP - 1022 EP - 6 JF - Kidney international JO - Kidney Int. VL - 64 IS - 3 N2 - Approximately 10 million adults in the United States have experienced the passage of a kidney stone, and up to 5 million have been diagnosed with gout by a physician. Previous reports have suggested that gout increases the risk for the development of kidney stones, but there are no prospective data. We used data from a cohort of 51,529 male health care professionals to examine the independent association between gout and kidney stone disease. In a cross-sectional analysis of gout and kidney stone disease reported on the 1986 baseline questionnaire, the prevalence of kidney stone disease was almost twofold higher in men with history of gout compared to those without (15% vs. 8%). After adjusting for age and body mass index (BMI), a history of gout remained significantly associated with kidney stone disease (OR 1.88; 95% CI 1.68 to 2.11). We then prospectively examined the risk of incident kidney stones in men with and without a confirmed diagnosis of gout after excluding men who reported a history of kidney stone disease or gout on the baseline questionnaire. A confirmed diagnosis of gout increased the multivariate relative risk of incident kidney stones (RR 2.12; 95% CI 1.22 to 3.68). In contrast, a history of kidney stone disease was not associated with increased risk of gout (RR 1.05; 95% CI 0.54 to 2.07). In conclusion, a history of gout independently increases the risk for incident kidney stones in men. Physicians should provide dietary counseling, such as increasing fluid intake and decreasing salt consumption, to subjects with gout in addition to other risk factors, such as family history of kidney stones, in order to decrease the likelihood of stone formation. SN - 0085-2538 UR - https://www.unboundmedicine.com/medline/citation/12911552/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)49423-2 DB - PRIME DP - Unbound Medicine ER -