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Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature.

Abstract

Animal experiments and human ecological studies suggest that dietary fat intake is associated with a risk of breast cancer, but individual-based studies have given contradictory results. We have carried out a meta-analysis of this association to include all papers published up to July 2003. Case-control and cohort studies that examined the association of dietary fat, or fat-containing foods, with risk of breast cancer were identified. A total of 45 risk estimates for total fat intake were obtained. Descriptive data from each study were extracted with an estimate of relative risk and its associated 95% confidence interval (CI), and were analysed using the random effects model of DerSimonian and Laird. The summary relative risk, comparing the highest and lowest levels of intake of total fat, was 1.13 (95% CI: 1.03-1.25). Cohort studies (N=14) had a summary relative risk of 1.11 (95% CI: 0.99-1.25) and case-control studies (N=31) had a relative risk of 1.14 (95% CI 0.99-1.32). Significant summary relative risks were also found for saturated fat (RR, 1.19; 95% CI: 1.06-1.35) and meat intake (RR, 1.17; 95% CI 1.06-1.29). Combined estimates of risk for total and saturated fat intake, and for meat intake, all indicate an association between higher intakes and an increased risk of breast cancer. Case-control and cohort studies gave similar results.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 1K9. boyd@uhnres.otoronto.ca

    , , , ,

    Source

    British journal of cancer 89:9 2003 Nov 03 pg 1672-85

    MeSH

    Breast Neoplasms
    Case-Control Studies
    Cohort Studies
    Dietary Fats
    Humans
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14583769

    Citation

    Boyd, N F., et al. "Dietary Fat and Breast Cancer Risk Revisited: a Meta-analysis of the Published Literature." British Journal of Cancer, vol. 89, no. 9, 2003, pp. 1672-85.
    Boyd NF, Stone J, Vogt KN, et al. Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer. 2003;89(9):1672-85.
    Boyd, N. F., Stone, J., Vogt, K. N., Connelly, B. S., Martin, L. J., & Minkin, S. (2003). Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. British Journal of Cancer, 89(9), pp. 1672-85.
    Boyd NF, et al. Dietary Fat and Breast Cancer Risk Revisited: a Meta-analysis of the Published Literature. Br J Cancer. 2003 Nov 3;89(9):1672-85. PubMed PMID: 14583769.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. AU - Boyd,N F, AU - Stone,J, AU - Vogt,K N, AU - Connelly,B S, AU - Martin,L J, AU - Minkin,S, PY - 2003/10/30/pubmed PY - 2003/12/25/medline PY - 2003/10/30/entrez SP - 1672 EP - 85 JF - British journal of cancer JO - Br. J. Cancer VL - 89 IS - 9 N2 - Animal experiments and human ecological studies suggest that dietary fat intake is associated with a risk of breast cancer, but individual-based studies have given contradictory results. We have carried out a meta-analysis of this association to include all papers published up to July 2003. Case-control and cohort studies that examined the association of dietary fat, or fat-containing foods, with risk of breast cancer were identified. A total of 45 risk estimates for total fat intake were obtained. Descriptive data from each study were extracted with an estimate of relative risk and its associated 95% confidence interval (CI), and were analysed using the random effects model of DerSimonian and Laird. The summary relative risk, comparing the highest and lowest levels of intake of total fat, was 1.13 (95% CI: 1.03-1.25). Cohort studies (N=14) had a summary relative risk of 1.11 (95% CI: 0.99-1.25) and case-control studies (N=31) had a relative risk of 1.14 (95% CI 0.99-1.32). Significant summary relative risks were also found for saturated fat (RR, 1.19; 95% CI: 1.06-1.35) and meat intake (RR, 1.17; 95% CI 1.06-1.29). Combined estimates of risk for total and saturated fat intake, and for meat intake, all indicate an association between higher intakes and an increased risk of breast cancer. Case-control and cohort studies gave similar results. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/14583769/full_citation L2 - http://dx.doi.org/10.1038/sj.bjc.6601314 DB - PRIME DP - Unbound Medicine ER -