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The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults.

Abstract

BACKGROUND

The objective of the investigation was to explore in a prospective study the associations between dietary intake of fatty acids, antioxidants and hay fever manifestation in adulthood.

METHODS

Three hundred and thirty-four hay fever cases with adult onset of clinical symptoms from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort were identified during follow-up and matched with 1336 controls. Dietary intake data were obtained by means of validated food frequency questionnaires. The influence of dietary fatty acid and vitamin intake on hay fever risk was estimated by means of unconditional logistic regression.

RESULTS

High intake of oleic acid was positively associated with hay fever [odds ratio (OR): 2.86, 95% confidence intervals (95% CI): 1.22-6.70], whereas high intake of eicosapentaenoic acid was inversely related to hay fever (OR: 0.45, 95% CI: 0.22-0.93). Furthermore, high beta-carotene intake increased the risk of hay fever (OR: 1.69, 95% CI: 1.09-2.63) while increasing intake of vitamin E was a protective factor (OR: 0.38, 95% CI: 0.17-0.85). In grouped analyses, the effects of beta-carotene and vitamin E were mainly observed among women and ex-/current-smokers; in these subgroups, linoleic acid increased the risk of hay fever.

CONCLUSIONS

In conclusion, the present results provide further evidence that dietary factors might affect the risk of clinical manifestation of hay fever. However, the effects in smokers and women may suggest different biological mechanisms for the investigated nutrients, which need further research.

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  • Authors+Show Affiliations

    ,

    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany.

    , ,

    Source

    Allergy 58:12 2003 Dec pg 1277-84

    MeSH

    Adult
    Aged
    Antioxidants
    Case-Control Studies
    Cohort Studies
    Eating
    Fatty Acids
    Female
    Humans
    Male
    Middle Aged
    Prospective Studies
    Rhinitis, Allergic, Seasonal
    Vitamins

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14616103

    Citation

    Nagel, G, et al. "The Influence of the Dietary Intake of Fatty Acids and Antioxidants On Hay Fever in Adults." Allergy, vol. 58, no. 12, 2003, pp. 1277-84.
    Nagel G, Nieters A, Becker N, et al. The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy. 2003;58(12):1277-84.
    Nagel, G., Nieters, A., Becker, N., & Linseisen, J. (2003). The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy, 58(12), pp. 1277-84.
    Nagel G, et al. The Influence of the Dietary Intake of Fatty Acids and Antioxidants On Hay Fever in Adults. Allergy. 2003;58(12):1277-84. PubMed PMID: 14616103.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. AU - Nagel,G, AU - Nieters,A, AU - Becker,N, AU - Linseisen,J, PY - 2003/11/18/pubmed PY - 2004/4/15/medline PY - 2003/11/18/entrez SP - 1277 EP - 84 JF - Allergy JO - Allergy VL - 58 IS - 12 N2 - BACKGROUND: The objective of the investigation was to explore in a prospective study the associations between dietary intake of fatty acids, antioxidants and hay fever manifestation in adulthood. METHODS: Three hundred and thirty-four hay fever cases with adult onset of clinical symptoms from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort were identified during follow-up and matched with 1336 controls. Dietary intake data were obtained by means of validated food frequency questionnaires. The influence of dietary fatty acid and vitamin intake on hay fever risk was estimated by means of unconditional logistic regression. RESULTS: High intake of oleic acid was positively associated with hay fever [odds ratio (OR): 2.86, 95% confidence intervals (95% CI): 1.22-6.70], whereas high intake of eicosapentaenoic acid was inversely related to hay fever (OR: 0.45, 95% CI: 0.22-0.93). Furthermore, high beta-carotene intake increased the risk of hay fever (OR: 1.69, 95% CI: 1.09-2.63) while increasing intake of vitamin E was a protective factor (OR: 0.38, 95% CI: 0.17-0.85). In grouped analyses, the effects of beta-carotene and vitamin E were mainly observed among women and ex-/current-smokers; in these subgroups, linoleic acid increased the risk of hay fever. CONCLUSIONS: In conclusion, the present results provide further evidence that dietary factors might affect the risk of clinical manifestation of hay fever. However, the effects in smokers and women may suggest different biological mechanisms for the investigated nutrients, which need further research. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/14616103/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=2003&volume=58&issue=12&spage=1277 DB - PRIME DP - Unbound Medicine ER -