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Stopping smoking can cause constipation.

Abstract

SETTING

Constipation is mentioned occasionally as a possible tobacco withdrawal symptom, but no systematic data have been published on this issue.

DESIGN

Smokers' clinic patients provided ratings of their level of constipation on three occasions prior to their quit date, and then weekly after they stopped smoking. The total of 1067 participants maintained at least 1 week of continuous abstinence and provided usable data.

FINDINGS

The three precessation ratings of constipation were stable. After cessation of smoking, the ratings increased significantly (P < 0.01). In 514 patients who maintained continuous abstinence for 4 weeks and provided complete data, constipation peaked at 2 weeks but remained elevated over the whole period. The net proportion of patients affected was 17%, including 9% who were symptom-free at baseline and became very or extremely constipated. In patients on nicotine replacement the increase in constipation, although significant, was less than in patients on bupropion.

CONCLUSIONS

Clinicians treating smokers need to be aware of a possibility that one in six quitters develop constipation, and that for about one in 11 the problem can be severe. Descriptions of tobacco withdrawal syndrome should include constipation.

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  • Authors+Show Affiliations

    ,

    Barts and The London, Queen Mary's School of Medicine and Dentistry, University of London, UK. p.hajek@qmul.ac.uk

    ,

    Source

    Addiction (Abingdon, England) 98:11 2003 Nov pg 1563-7

    MeSH

    Bupropion
    Constipation
    Dopamine Uptake Inhibitors
    Female
    Humans
    Male
    Middle Aged
    Nicotine
    Psychiatric Status Rating Scales
    Smoking
    Smoking Cessation
    Substance Withdrawal Syndrome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14616182

    Citation

    Hajek, Peter, et al. "Stopping Smoking Can Cause Constipation." Addiction (Abingdon, England), vol. 98, no. 11, 2003, pp. 1563-7.
    Hajek P, Gillison F, McRobbie H. Stopping smoking can cause constipation. Addiction. 2003;98(11):1563-7.
    Hajek, P., Gillison, F., & McRobbie, H. (2003). Stopping smoking can cause constipation. Addiction (Abingdon, England), 98(11), pp. 1563-7.
    Hajek P, Gillison F, McRobbie H. Stopping Smoking Can Cause Constipation. Addiction. 2003;98(11):1563-7. PubMed PMID: 14616182.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Stopping smoking can cause constipation. AU - Hajek,Peter, AU - Gillison,Fiona, AU - McRobbie,Hayden, PY - 2003/11/18/pubmed PY - 2004/3/3/medline PY - 2003/11/18/entrez SP - 1563 EP - 7 JF - Addiction (Abingdon, England) JO - Addiction VL - 98 IS - 11 N2 - SETTING: Constipation is mentioned occasionally as a possible tobacco withdrawal symptom, but no systematic data have been published on this issue. DESIGN: Smokers' clinic patients provided ratings of their level of constipation on three occasions prior to their quit date, and then weekly after they stopped smoking. The total of 1067 participants maintained at least 1 week of continuous abstinence and provided usable data. FINDINGS: The three precessation ratings of constipation were stable. After cessation of smoking, the ratings increased significantly (P < 0.01). In 514 patients who maintained continuous abstinence for 4 weeks and provided complete data, constipation peaked at 2 weeks but remained elevated over the whole period. The net proportion of patients affected was 17%, including 9% who were symptom-free at baseline and became very or extremely constipated. In patients on nicotine replacement the increase in constipation, although significant, was less than in patients on bupropion. CONCLUSIONS: Clinicians treating smokers need to be aware of a possibility that one in six quitters develop constipation, and that for about one in 11 the problem can be severe. Descriptions of tobacco withdrawal syndrome should include constipation. SN - 0965-2140 UR - https://www.unboundmedicine.com/medline/citation/14616182/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0965-2140&amp;date=2003&amp;volume=98&amp;issue=11&amp;spage=1563 DB - PRIME DP - Unbound Medicine ER -