Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis.
Head Neck. 2003 Dec; 25(12):1057-70.HN

Abstract

BACKGROUND

Oral mucositis is a common sequel of radiotherapy, chemotherapy, and radiochemotherapy in patients with cancer or patients requiring hemopoietic stem cell transplants. Mucositis has a direct and significant impact on the duration of disease remission and cure rates, because it is a cancer treatment-limiting toxicity. Mucositis also affects survival because of the risk of infection and has a significant impact on the quality of life and cost of care.

METHODS

This article reviews publications on the etiopathogenesis and prevention of oral mucositis accessible from a MEDLINE search using as key words, mucositis, radiotherapy, chemotherapy, hemopoietic stem cell transplant, and oral.

CONCLUSIONS

Of the current available products, ice chips and benzydamine have the strongest scientific evidence of support for prophylaxis of mucositis.

Authors+Show Affiliations

Scully C

Eastman Dental Institute for Oral Health Care Sciences, World Health Organisation Collaborating Centre for Oral Health, Disability and Cultures, University College London, University of London, London WC1X 8LD United Kingdom. c.scully@eastman.ucl.ac.uk

Epstein J

No affiliation info available

Sonis S

No affiliation info available

MeSH

Antineoplastic AgentsCombined Modality TherapyHumansMouth MucosaRadiotherapyStomatitis

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

14648865

Clinical Trial Links

Prevention of Radiation-induced Severe Oral Mucositis in Oral Cavity, Oropharynx, Hypopharynx, and Cavum Cancer

Can Cytokines Predict the Severity of Acute Mucositis and the Need for Gastrostomy Tubes (PEG)?

Citation

Scully, Crispian, et al. "Oral Mucositis: a Challenging Complication of Radiotherapy, Chemotherapy, and Radiochemotherapy: Part 1, Pathogenesis and Prophylaxis of Mucositis." Head & Neck, vol. 25, no. 12, 2003, pp. 1057-70.

Scully C, Epstein J, Sonis S. Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis. Head Neck. 2003;25(12):1057-70.

Scully, C., Epstein, J., & Sonis, S. (2003). Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis. Head & Neck, 25(12), 1057-70.

Scully C, Epstein J, Sonis S. Oral Mucositis: a Challenging Complication of Radiotherapy, Chemotherapy, and Radiochemotherapy: Part 1, Pathogenesis and Prophylaxis of Mucositis. Head Neck. 2003;25(12):1057-70. PubMed PMID: 14648865.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis. AU - Scully,Crispian, AU - Epstein,Joel, AU - Sonis,Stephen, PY - 2003/12/3/pubmed PY - 2004/4/24/medline PY - 2003/12/3/entrez SP - 1057 EP - 70 JF - Head & neck JO - Head Neck VL - 25 IS - 12 N2 - BACKGROUND: Oral mucositis is a common sequel of radiotherapy, chemotherapy, and radiochemotherapy in patients with cancer or patients requiring hemopoietic stem cell transplants. Mucositis has a direct and significant impact on the duration of disease remission and cure rates, because it is a cancer treatment-limiting toxicity. Mucositis also affects survival because of the risk of infection and has a significant impact on the quality of life and cost of care. METHODS: This article reviews publications on the etiopathogenesis and prevention of oral mucositis accessible from a MEDLINE search using as key words, mucositis, radiotherapy, chemotherapy, hemopoietic stem cell transplant, and oral. CONCLUSIONS: Of the current available products, ice chips and benzydamine have the strongest scientific evidence of support for prophylaxis of mucositis. SN - 1043-3074 UR - https://www.unboundmedicine.com/medline/citation/14648865/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis.Head Neck. 2003 Dec; 25(12):1057-70.HN