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Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study.
Am J Clin Nutr 2003; 78(6):1085-91AJ

Abstract

BACKGROUND

Several epidemiologic studies found weak protective relations between dietary fiber intake and the risk of cardiovascular disease events. However, few of the studies addressed possible mechanisms of the effect.

OBJECTIVE

In the present study, we estimated relations between the progression of atherosclerosis and the intake of selective dietary fiber fractions. Mediation of the relations by serum lipids was also investigated.

DESIGN

Participants who were free of heart disease and aged 40-60 y were recruited into the cohort (n = 573; 47% women). The intima-media thickness (IMT) of the common carotid arteries was measured ultrasonographically at the baseline examination and at 2 follow-up examinations (n = 500), dietary intakes were assessed with six 24-h recalls (3 at baseline and 3 at the first follow-up examination), and blood samples were analyzed at baseline and at both follow-up examinations.

RESULTS

A significant inverse association was observed between IMT progression and the intakes of viscous fiber (P = 0.05) and pectin (P = 0.01). Correction for measurement error increased the magnitude of these estimated effects. The ratio of total to HDL cholesterol was inversely related to the intakes of total fiber (P = 0.01), viscous fiber (P = 0.05), and pectin (P = 0.01). The magnitude of the association between IMT progression and the intakes of viscous fiber and pectin was attenuated by adjustment for serum lipids.

CONCLUSIONS

The intake of viscous fiber, especially pectin, appears to protect against IMT progression. Serum lipids may act as a mediator between dietary fiber intake and IMT progression.

Authors+Show Affiliations

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14668268

Citation

Wu, Huiyun, et al. "Dietary Fiber and Progression of Atherosclerosis: the Los Angeles Atherosclerosis Study." The American Journal of Clinical Nutrition, vol. 78, no. 6, 2003, pp. 1085-91.
Wu H, Dwyer KM, Fan Z, et al. Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Clin Nutr. 2003;78(6):1085-91.
Wu, H., Dwyer, K. M., Fan, Z., Shircore, A., Fan, J., & Dwyer, J. H. (2003). Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. The American Journal of Clinical Nutrition, 78(6), pp. 1085-91.
Wu H, et al. Dietary Fiber and Progression of Atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Clin Nutr. 2003;78(6):1085-91. PubMed PMID: 14668268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. AU - Wu,Huiyun, AU - Dwyer,Kathleen M, AU - Fan,Zhihong, AU - Shircore,Anne, AU - Fan,Jing, AU - Dwyer,James H, PY - 2003/12/12/pubmed PY - 2004/1/6/medline PY - 2003/12/12/entrez SP - 1085 EP - 91 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 78 IS - 6 N2 - BACKGROUND: Several epidemiologic studies found weak protective relations between dietary fiber intake and the risk of cardiovascular disease events. However, few of the studies addressed possible mechanisms of the effect. OBJECTIVE: In the present study, we estimated relations between the progression of atherosclerosis and the intake of selective dietary fiber fractions. Mediation of the relations by serum lipids was also investigated. DESIGN: Participants who were free of heart disease and aged 40-60 y were recruited into the cohort (n = 573; 47% women). The intima-media thickness (IMT) of the common carotid arteries was measured ultrasonographically at the baseline examination and at 2 follow-up examinations (n = 500), dietary intakes were assessed with six 24-h recalls (3 at baseline and 3 at the first follow-up examination), and blood samples were analyzed at baseline and at both follow-up examinations. RESULTS: A significant inverse association was observed between IMT progression and the intakes of viscous fiber (P = 0.05) and pectin (P = 0.01). Correction for measurement error increased the magnitude of these estimated effects. The ratio of total to HDL cholesterol was inversely related to the intakes of total fiber (P = 0.01), viscous fiber (P = 0.05), and pectin (P = 0.01). The magnitude of the association between IMT progression and the intakes of viscous fiber and pectin was attenuated by adjustment for serum lipids. CONCLUSIONS: The intake of viscous fiber, especially pectin, appears to protect against IMT progression. Serum lipids may act as a mediator between dietary fiber intake and IMT progression. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/14668268/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/78.6.1085 DB - PRIME DP - Unbound Medicine ER -