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Vitamin D intake and incidence of multiple sclerosis.
Neurology 2004; 62(1):60-5Neur

Abstract

BACKGROUND

A protective effect of vitamin D on risk of multiple sclerosis (MS) has been proposed, but no prospective studies have addressed this hypothesis.

METHODS

Dietary vitamin D intake was examined directly in relation to risk of MS in two large cohorts of women: the Nurses' Health Study (NHS; 92,253 women followed from 1980 to 2000) and Nurses' Health Study II (NHS II; 95,310 women followed from 1991 to 2001). Diet was assessed at baseline and updated every 4 years thereafter. During the follow-up, 173 cases of MS with onset of symptoms after baseline were confirmed.

RESULTS

The pooled age-adjusted relative risk (RR) comparing women in the highest quintile of total vitamin D intake at baseline with those in the lowest was 0.67 (95% CI = 0.40 to 1.12; p for trend = 0.03). Intake of vitamin D from supplements was also inversely associated with risk of MS; the RR comparing women with intake of >or=400 IU/day with women with no supplemental vitamin D intake was 0.59 (95% CI = 0.38 to 0.91; p for trend = 0.006). No association was found between vitamin D from food and MS incidence.

CONCLUSION

These results support a protective effect of vitamin D intake on risk of developing MS.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA. kgorham@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14718698

Citation

Munger, K L., et al. "Vitamin D Intake and Incidence of Multiple Sclerosis." Neurology, vol. 62, no. 1, 2004, pp. 60-5.
Munger KL, Zhang SM, O'Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004;62(1):60-5.
Munger, K. L., Zhang, S. M., O'Reilly, E., Hernán, M. A., Olek, M. J., Willett, W. C., & Ascherio, A. (2004). Vitamin D intake and incidence of multiple sclerosis. Neurology, 62(1), pp. 60-5.
Munger KL, et al. Vitamin D Intake and Incidence of Multiple Sclerosis. Neurology. 2004 Jan 13;62(1):60-5. PubMed PMID: 14718698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D intake and incidence of multiple sclerosis. AU - Munger,K L, AU - Zhang,S M, AU - O'Reilly,E, AU - Hernán,M A, AU - Olek,M J, AU - Willett,W C, AU - Ascherio,A, PY - 2004/1/14/pubmed PY - 2004/3/5/medline PY - 2004/1/14/entrez SP - 60 EP - 5 JF - Neurology JO - Neurology VL - 62 IS - 1 N2 - BACKGROUND: A protective effect of vitamin D on risk of multiple sclerosis (MS) has been proposed, but no prospective studies have addressed this hypothesis. METHODS: Dietary vitamin D intake was examined directly in relation to risk of MS in two large cohorts of women: the Nurses' Health Study (NHS; 92,253 women followed from 1980 to 2000) and Nurses' Health Study II (NHS II; 95,310 women followed from 1991 to 2001). Diet was assessed at baseline and updated every 4 years thereafter. During the follow-up, 173 cases of MS with onset of symptoms after baseline were confirmed. RESULTS: The pooled age-adjusted relative risk (RR) comparing women in the highest quintile of total vitamin D intake at baseline with those in the lowest was 0.67 (95% CI = 0.40 to 1.12; p for trend = 0.03). Intake of vitamin D from supplements was also inversely associated with risk of MS; the RR comparing women with intake of >or=400 IU/day with women with no supplemental vitamin D intake was 0.59 (95% CI = 0.38 to 0.91; p for trend = 0.006). No association was found between vitamin D from food and MS incidence. CONCLUSION: These results support a protective effect of vitamin D intake on risk of developing MS. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/14718698/full_citation L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=14718698 DB - PRIME DP - Unbound Medicine ER -