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Vitamin D intake and incidence of multiple sclerosis.

Abstract

BACKGROUND

A protective effect of vitamin D on risk of multiple sclerosis (MS) has been proposed, but no prospective studies have addressed this hypothesis.

METHODS

Dietary vitamin D intake was examined directly in relation to risk of MS in two large cohorts of women: the Nurses' Health Study (NHS; 92,253 women followed from 1980 to 2000) and Nurses' Health Study II (NHS II; 95,310 women followed from 1991 to 2001). Diet was assessed at baseline and updated every 4 years thereafter. During the follow-up, 173 cases of MS with onset of symptoms after baseline were confirmed.

RESULTS

The pooled age-adjusted relative risk (RR) comparing women in the highest quintile of total vitamin D intake at baseline with those in the lowest was 0.67 (95% CI = 0.40 to 1.12; p for trend = 0.03). Intake of vitamin D from supplements was also inversely associated with risk of MS; the RR comparing women with intake of >or=400 IU/day with women with no supplemental vitamin D intake was 0.59 (95% CI = 0.38 to 0.91; p for trend = 0.006). No association was found between vitamin D from food and MS incidence.

CONCLUSION

These results support a protective effect of vitamin D intake on risk of developing MS.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA. kgorham@hsph.harvard.edu

    , , , , ,

    Source

    Neurology 62:1 2004 Jan 13 pg 60-5

    MeSH

    Adolescent
    Adult
    Diet
    Dietary Supplements
    Female
    Follow-Up Studies
    Humans
    Incidence
    Middle Aged
    Multiple Sclerosis
    Nurses
    Odds Ratio
    Prospective Studies
    Risk
    United States
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14718698

    Citation

    Munger, K L., et al. "Vitamin D Intake and Incidence of Multiple Sclerosis." Neurology, vol. 62, no. 1, 2004, pp. 60-5.
    Munger KL, Zhang SM, O'Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004;62(1):60-5.
    Munger, K. L., Zhang, S. M., O'Reilly, E., Hernán, M. A., Olek, M. J., Willett, W. C., & Ascherio, A. (2004). Vitamin D intake and incidence of multiple sclerosis. Neurology, 62(1), pp. 60-5.
    Munger KL, et al. Vitamin D Intake and Incidence of Multiple Sclerosis. Neurology. 2004 Jan 13;62(1):60-5. PubMed PMID: 14718698.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D intake and incidence of multiple sclerosis. AU - Munger,K L, AU - Zhang,S M, AU - O'Reilly,E, AU - Hernán,M A, AU - Olek,M J, AU - Willett,W C, AU - Ascherio,A, PY - 2004/1/14/pubmed PY - 2004/3/5/medline PY - 2004/1/14/entrez SP - 60 EP - 5 JF - Neurology JO - Neurology VL - 62 IS - 1 N2 - BACKGROUND: A protective effect of vitamin D on risk of multiple sclerosis (MS) has been proposed, but no prospective studies have addressed this hypothesis. METHODS: Dietary vitamin D intake was examined directly in relation to risk of MS in two large cohorts of women: the Nurses' Health Study (NHS; 92,253 women followed from 1980 to 2000) and Nurses' Health Study II (NHS II; 95,310 women followed from 1991 to 2001). Diet was assessed at baseline and updated every 4 years thereafter. During the follow-up, 173 cases of MS with onset of symptoms after baseline were confirmed. RESULTS: The pooled age-adjusted relative risk (RR) comparing women in the highest quintile of total vitamin D intake at baseline with those in the lowest was 0.67 (95% CI = 0.40 to 1.12; p for trend = 0.03). Intake of vitamin D from supplements was also inversely associated with risk of MS; the RR comparing women with intake of >or=400 IU/day with women with no supplemental vitamin D intake was 0.59 (95% CI = 0.38 to 0.91; p for trend = 0.006). No association was found between vitamin D from food and MS incidence. CONCLUSION: These results support a protective effect of vitamin D intake on risk of developing MS. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/14718698/full_citation L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=14718698 DB - PRIME DP - Unbound Medicine ER -