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Status of blood antioxidant enzymes in alcoholic cirrhosis.

Abstract

Chronic alcohol consumption is associated with increased incidence of variety of illnesses including cirrhosis. Studies have shown that ethanol consumption may result in increased oxidative stress with increased formation of lipid peroxides and free radicals. However, very few reports are available on their involvement in the toxicity of alcoholic cirrhosis. The present study was undertaken in 44 male subjects to evaluate the role of oxidative stress in liver injury with special reference to alcoholic or non alcoholic cirrhosis. It was observed that the parameters of liver function like total bilirubin, Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), gamma Glutamyl transfarase (gammaGT) were increased in cirrhotic (alcoholic or non alcoholic) patients as compared to normal controls. However antioxidant enzymes like Superoxide dismutase (SOD) and Glutathine peroxidase (GPx) lipid peroxidation marker, Malondialdehyde (MDA) showed significant changes only in alcoholic cirrhosis and not in non alcoholic cirrhosis when compared with normal controls. The possibility of assessment of antioxidant enzymes to differentiate between alcoholic or non alcoholic or non alcoholic cirrhosis is postulated.

Authors+Show Affiliations

,

Department of Biochemistry, Indira Gandhi Medical College, Nagpur 440 018.

Source

MeSH

Adult
Antioxidants
Bilirubin
Diagnosis, Differential
Erythrocytes
Glutathione Peroxidase
Humans
Liver Cirrhosis
Liver Cirrhosis, Alcoholic
Liver Function Tests
Male
Malondialdehyde
Oxidative Stress
Superoxide Dismutase
gamma-Glutamyltransferase

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

14723322

Citation

Chari, Suresh, and Madhur Gupta. "Status of Blood Antioxidant Enzymes in Alcoholic Cirrhosis." Indian Journal of Physiology and Pharmacology, vol. 47, no. 3, 2003, pp. 343-6.
Chari S, Gupta M. Status of blood antioxidant enzymes in alcoholic cirrhosis. Indian J Physiol Pharmacol. 2003;47(3):343-6.
Chari, S., & Gupta, M. (2003). Status of blood antioxidant enzymes in alcoholic cirrhosis. Indian Journal of Physiology and Pharmacology, 47(3), pp. 343-6.
Chari S, Gupta M. Status of Blood Antioxidant Enzymes in Alcoholic Cirrhosis. Indian J Physiol Pharmacol. 2003;47(3):343-6. PubMed PMID: 14723322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Status of blood antioxidant enzymes in alcoholic cirrhosis. AU - Chari,Suresh, AU - Gupta,Madhur, PY - 2004/1/16/pubmed PY - 2004/8/26/medline PY - 2004/1/16/entrez SP - 343 EP - 6 JF - Indian journal of physiology and pharmacology JO - Indian J. Physiol. Pharmacol. VL - 47 IS - 3 N2 - Chronic alcohol consumption is associated with increased incidence of variety of illnesses including cirrhosis. Studies have shown that ethanol consumption may result in increased oxidative stress with increased formation of lipid peroxides and free radicals. However, very few reports are available on their involvement in the toxicity of alcoholic cirrhosis. The present study was undertaken in 44 male subjects to evaluate the role of oxidative stress in liver injury with special reference to alcoholic or non alcoholic cirrhosis. It was observed that the parameters of liver function like total bilirubin, Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), gamma Glutamyl transfarase (gammaGT) were increased in cirrhotic (alcoholic or non alcoholic) patients as compared to normal controls. However antioxidant enzymes like Superoxide dismutase (SOD) and Glutathine peroxidase (GPx) lipid peroxidation marker, Malondialdehyde (MDA) showed significant changes only in alcoholic cirrhosis and not in non alcoholic cirrhosis when compared with normal controls. The possibility of assessment of antioxidant enzymes to differentiate between alcoholic or non alcoholic or non alcoholic cirrhosis is postulated. SN - 0019-5499 UR - https://www.unboundmedicine.com/medline/citation/14723322/full_citation L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -