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Synthesis of vitamin D in skin after burns.

Abstract

Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.

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  • Authors+Show Affiliations

    ,

    Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555-0352, USA. gklein@utmb.edu

    , , , , ,

    Source

    Lancet (London, England) 363:9405 2004 Jan 24 pg 291-2

    MeSH

    Adolescent
    Burns
    Child
    Child, Preschool
    Cholecalciferol
    Dietary Supplements
    Female
    Follow-Up Studies
    Humans
    Male
    Skin
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14751703

    Citation

    Klein, Gordon L., et al. "Synthesis of Vitamin D in Skin After Burns." Lancet (London, England), vol. 363, no. 9405, 2004, pp. 291-2.
    Klein GL, Chen TC, Holick MF, et al. Synthesis of vitamin D in skin after burns. Lancet. 2004;363(9405):291-2.
    Klein, G. L., Chen, T. C., Holick, M. F., Langman, C. B., Price, H., Celis, M. M., & Herndon, D. N. (2004). Synthesis of vitamin D in skin after burns. Lancet (London, England), 363(9405), pp. 291-2.
    Klein GL, et al. Synthesis of Vitamin D in Skin After Burns. Lancet. 2004 Jan 24;363(9405):291-2. PubMed PMID: 14751703.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Synthesis of vitamin D in skin after burns. AU - Klein,Gordon L, AU - Chen,Tai C, AU - Holick,Michael F, AU - Langman,Craig B, AU - Price,Heather, AU - Celis,Mario M, AU - Herndon,David N, PY - 2004/1/31/pubmed PY - 2004/3/10/medline PY - 2004/1/31/entrez SP - 291 EP - 2 JF - Lancet (London, England) JO - Lancet VL - 363 IS - 9405 N2 - Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/14751703/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(03)15388-3 DB - PRIME DP - Unbound Medicine ER -