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Magnesium intake and risk of coronary heart disease among men.

Abstract

OBJECTIVE

Our aim in this study was to assess the relationship between magnesium intake and risk of coronary heart disease (CHD) among men.

METHODS

A total of 39,633 men in the Health Professionals Follow-up Study who returned a dietary questionnaire in 1986 were followed up for 12 years. Intakes of magnesium, zinc and potassium and other nutrients were assessed in 1986, 1990 and 1994. Total CHD incidence (nonfatal myocardial infarction (MI) and fatal CHD) was ascertained by biennial questionnaire and mortality surveillance confirmed by medical record review. Standard CHD risk factors were recorded biennially.

RESULTS

During 12 years of follow-up (414,285 person-years), we documented 1,449 cases of total CHD (1,021 non-fatal MI cases, and 428 fatal CHD). The age-adjusted relative risk (RR) of developing CHD in the highest quintile (median intake = 457 mg/day) compared with the lowest quintile (median intake = 269 mg/day) was 0.73 (95% CI 0.62-0.87, p for trend <0.0001). After controlling for standard CHD risk factors and dietary factors, the RR for developing CHD among men in the highest total magnesium intake quintile compared with those in the lowest was 0.82 (95% CI 0.65-1.05, p for trend = 0.08). For supplemental magnesium intake, the RR comparing the highest quintile to non-supplement users was 0.77 (95% CI 0.56-1.06, p for trend = 0.14).

CONCLUSIONS

These results suggest that intake of magnesium may have a modest inverse association with risk of CHD among men.

Authors+Show Affiliations

,

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. wael@hsph.harvard.edu

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Source

MeSH

Adult
Aged
Cohort Studies
Coronary Disease
Follow-Up Studies
Humans
Incidence
Magnesium
Male
Middle Aged
Potassium
Risk Factors
Surveys and Questionnaires
Survival Analysis
Zinc

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14963055

Citation

Al-Delaimy, Wael K., et al. "Magnesium Intake and Risk of Coronary Heart Disease Among Men." Journal of the American College of Nutrition, vol. 23, no. 1, 2004, pp. 63-70.
Al-Delaimy WK, Rimm EB, Willett WC, et al. Magnesium intake and risk of coronary heart disease among men. J Am Coll Nutr. 2004;23(1):63-70.
Al-Delaimy, W. K., Rimm, E. B., Willett, W. C., Stampfer, M. J., & Hu, F. B. (2004). Magnesium intake and risk of coronary heart disease among men. Journal of the American College of Nutrition, 23(1), pp. 63-70.
Al-Delaimy WK, et al. Magnesium Intake and Risk of Coronary Heart Disease Among Men. J Am Coll Nutr. 2004;23(1):63-70. PubMed PMID: 14963055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium intake and risk of coronary heart disease among men. AU - Al-Delaimy,Wael K, AU - Rimm,Eric B, AU - Willett,Walter C, AU - Stampfer,Meir J, AU - Hu,Frank B, PY - 2004/2/14/pubmed PY - 2004/5/5/medline PY - 2004/2/14/entrez SP - 63 EP - 70 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 23 IS - 1 N2 - OBJECTIVE: Our aim in this study was to assess the relationship between magnesium intake and risk of coronary heart disease (CHD) among men. METHODS: A total of 39,633 men in the Health Professionals Follow-up Study who returned a dietary questionnaire in 1986 were followed up for 12 years. Intakes of magnesium, zinc and potassium and other nutrients were assessed in 1986, 1990 and 1994. Total CHD incidence (nonfatal myocardial infarction (MI) and fatal CHD) was ascertained by biennial questionnaire and mortality surveillance confirmed by medical record review. Standard CHD risk factors were recorded biennially. RESULTS: During 12 years of follow-up (414,285 person-years), we documented 1,449 cases of total CHD (1,021 non-fatal MI cases, and 428 fatal CHD). The age-adjusted relative risk (RR) of developing CHD in the highest quintile (median intake = 457 mg/day) compared with the lowest quintile (median intake = 269 mg/day) was 0.73 (95% CI 0.62-0.87, p for trend <0.0001). After controlling for standard CHD risk factors and dietary factors, the RR for developing CHD among men in the highest total magnesium intake quintile compared with those in the lowest was 0.82 (95% CI 0.65-1.05, p for trend = 0.08). For supplemental magnesium intake, the RR comparing the highest quintile to non-supplement users was 0.77 (95% CI 0.56-1.06, p for trend = 0.14). CONCLUSIONS: These results suggest that intake of magnesium may have a modest inverse association with risk of CHD among men. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/14963055/full_citation L2 - https://ClinicalTrials.gov/search/term=14963055 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -