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Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study.

Abstract

Alcohol drinking has been extensively studied in relation to prostate cancer, yet findings on the direction of the association are equivocal. Previous studies have not examined drinking patterns. Thus, the authors prospectively evaluated the associations between these factors and risk of incident prostate cancer (n = 2,479) in a cohort study of 47,843 US men (1986-1998). The men completed a questionnaire at baseline that included information on consumption of specific types of alcohol and frequency of use. The authors estimated hazard ratios using Cox proportional hazards regression for average alcohol intake and number of days per week on which alcohol was consumed stratified by average weekly intake (<105 g/week vs. > or = 105 g/week). Compared with nondrinking, the hazard ratio for consumption increased slightly from an average of 5.0-14.9 g/day (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 0.94, 1.18) to 30.0-49.9 g/day (HR = 1.13, 95% CI: 0.96, 1.33), but it was not increased at > or = 50 g/day (HR = 1.00, 95% CI: 0.77, 1.31) after adjustment for recent smoking and other factors. Compared with abstainers, risk was greatest among men who consumed an average of > or = 105 g/week but who drank on only 1-2 days per week (HR = 1.64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. eplatz@jhsph.edu

    , , ,

    Source

    American journal of epidemiology 159:5 2004 Mar 01 pg 444-53

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Cohort Studies
    Humans
    Incidence
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Prostatic Neoplasms
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14977640

    Citation

    Platz, Elizabeth A., et al. "Alcohol Intake, Drinking Patterns, and Risk of Prostate Cancer in a Large Prospective Cohort Study." American Journal of Epidemiology, vol. 159, no. 5, 2004, pp. 444-53.
    Platz EA, Leitzmann MF, Rimm EB, et al. Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study. Am J Epidemiol. 2004;159(5):444-53.
    Platz, E. A., Leitzmann, M. F., Rimm, E. B., Willett, W. C., & Giovannucci, E. (2004). Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study. American Journal of Epidemiology, 159(5), pp. 444-53.
    Platz EA, et al. Alcohol Intake, Drinking Patterns, and Risk of Prostate Cancer in a Large Prospective Cohort Study. Am J Epidemiol. 2004 Mar 1;159(5):444-53. PubMed PMID: 14977640.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study. AU - Platz,Elizabeth A, AU - Leitzmann,Michael F, AU - Rimm,Eric B, AU - Willett,Walter C, AU - Giovannucci,Edward, PY - 2004/2/24/pubmed PY - 2004/10/16/medline PY - 2004/2/24/entrez SP - 444 EP - 53 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 159 IS - 5 N2 - Alcohol drinking has been extensively studied in relation to prostate cancer, yet findings on the direction of the association are equivocal. Previous studies have not examined drinking patterns. Thus, the authors prospectively evaluated the associations between these factors and risk of incident prostate cancer (n = 2,479) in a cohort study of 47,843 US men (1986-1998). The men completed a questionnaire at baseline that included information on consumption of specific types of alcohol and frequency of use. The authors estimated hazard ratios using Cox proportional hazards regression for average alcohol intake and number of days per week on which alcohol was consumed stratified by average weekly intake (<105 g/week vs. > or = 105 g/week). Compared with nondrinking, the hazard ratio for consumption increased slightly from an average of 5.0-14.9 g/day (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 0.94, 1.18) to 30.0-49.9 g/day (HR = 1.13, 95% CI: 0.96, 1.33), but it was not increased at > or = 50 g/day (HR = 1.00, 95% CI: 0.77, 1.31) after adjustment for recent smoking and other factors. Compared with abstainers, risk was greatest among men who consumed an average of > or = 105 g/week but who drank on only 1-2 days per week (HR = 1.64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/14977640/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwh062 DB - PRIME DP - Unbound Medicine ER -