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Concentrations of B vitamins and homocysteine in children with sickle cell anemia.

Abstract

BACKGROUND

Elevated concentration of serum homocysteine contributes to thrombosis, a frequent event in patients with sickle cell anemia. We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover.

METHODS

We conducted a case-control study of children with homozygous sickle cell anemia (n = 17) and unaffected children (n = 11). We measured serum and red blood cell folate, vitamin B6, vitamin B12, and homocysteine concentrations, and assessed micronutrient intake.

RESULTS

Children with sickle cell anemia had concentrations of homocysteine slightly higher than those of unaffected children. They had lower vitamin B6 concentrations and comparable concentrations of folate and vitamin B12. Homocysteine concentration was inversely related to vitamin B12 concentration and was not independently associated with levels of vitamin B6 or folate.

CONCLUSION

Despite comparable intake, children with sickle cell anemia had lower concentrations of vitamin B6 than unaffected children. Larger studies are needed to determine if chronically low serum vitamin B6 concentration contributes to hyperhomocysteinemia in this population.

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  • Authors

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    Source

    Southern medical journal 97:2 2004 Feb pg 149-55

    MeSH

    African Continental Ancestry Group
    Anemia, Sickle Cell
    Case-Control Studies
    Child
    Diet
    Female
    Folic Acid
    Homocysteine
    Humans
    Male
    Vitamin B 6
    Vitamins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14982264

    Citation

    TY - JOUR T1 - Concentrations of B vitamins and homocysteine in children with sickle cell anemia. AU - Segal,Jodi B, AU - Miller,Edgar R,3rd AU - Brereton,Nga Hong, AU - Resar,Linda M S, PY - 2004/2/26/pubmed PY - 2004/3/10/medline PY - 2004/2/26/entrez SP - 149 EP - 55 JF - Southern medical journal JO - South. Med. J. VL - 97 IS - 2 N2 - BACKGROUND: Elevated concentration of serum homocysteine contributes to thrombosis, a frequent event in patients with sickle cell anemia. We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover. METHODS: We conducted a case-control study of children with homozygous sickle cell anemia (n = 17) and unaffected children (n = 11). We measured serum and red blood cell folate, vitamin B6, vitamin B12, and homocysteine concentrations, and assessed micronutrient intake. RESULTS: Children with sickle cell anemia had concentrations of homocysteine slightly higher than those of unaffected children. They had lower vitamin B6 concentrations and comparable concentrations of folate and vitamin B12. Homocysteine concentration was inversely related to vitamin B12 concentration and was not independently associated with levels of vitamin B6 or folate. CONCLUSION: Despite comparable intake, children with sickle cell anemia had lower concentrations of vitamin B6 than unaffected children. Larger studies are needed to determine if chronically low serum vitamin B6 concentration contributes to hyperhomocysteinemia in this population. SN - 0038-4348 UR - https://www.unboundmedicine.com/medline/citation/14982264/full_citation L2 - http://openurl.ebscohost.com/linksvc/linking.aspx?genre=article&sid=PubMed&issn=0038-4348&title=South Med J&volume=97&issue=2&spage=149&atitle=Concentrations of B vitamins and homocysteine in children with sickle cell anemia.&aulast=Segal&date=2004 ER -