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Concentrations of B vitamins and homocysteine in children with sickle cell anemia.
South Med J 2004; 97(2):149-55SM

Abstract

BACKGROUND

Elevated concentration of serum homocysteine contributes to thrombosis, a frequent event in patients with sickle cell anemia. We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover.

METHODS

We conducted a case-control study of children with homozygous sickle cell anemia (n = 17) and unaffected children (n = 11). We measured serum and red blood cell folate, vitamin B6, vitamin B12, and homocysteine concentrations, and assessed micronutrient intake.

RESULTS

Children with sickle cell anemia had concentrations of homocysteine slightly higher than those of unaffected children. They had lower vitamin B6 concentrations and comparable concentrations of folate and vitamin B12. Homocysteine concentration was inversely related to vitamin B12 concentration and was not independently associated with levels of vitamin B6 or folate.

CONCLUSION

Despite comparable intake, children with sickle cell anemia had lower concentrations of vitamin B6 than unaffected children. Larger studies are needed to determine if chronically low serum vitamin B6 concentration contributes to hyperhomocysteinemia in this population.

Authors+Show Affiliations

Department of Medicine and Pediatrics, the Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA. jsegal@jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14982264

Citation

Segal, Jodi B., et al. "Concentrations of B Vitamins and Homocysteine in Children With Sickle Cell Anemia." Southern Medical Journal, vol. 97, no. 2, 2004, pp. 149-55.
Segal JB, Miller ER, Brereton NH, et al. Concentrations of B vitamins and homocysteine in children with sickle cell anemia. South Med J. 2004;97(2):149-55.
Segal, J. B., Miller, E. R., Brereton, N. H., & Resar, L. M. (2004). Concentrations of B vitamins and homocysteine in children with sickle cell anemia. Southern Medical Journal, 97(2), pp. 149-55.
Segal JB, et al. Concentrations of B Vitamins and Homocysteine in Children With Sickle Cell Anemia. South Med J. 2004;97(2):149-55. PubMed PMID: 14982264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concentrations of B vitamins and homocysteine in children with sickle cell anemia. AU - Segal,Jodi B, AU - Miller,Edgar R,3rd AU - Brereton,Nga Hong, AU - Resar,Linda M S, PY - 2004/2/26/pubmed PY - 2004/3/10/medline PY - 2004/2/26/entrez SP - 149 EP - 55 JF - Southern medical journal JO - South. Med. J. VL - 97 IS - 2 N2 - BACKGROUND: Elevated concentration of serum homocysteine contributes to thrombosis, a frequent event in patients with sickle cell anemia. We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover. METHODS: We conducted a case-control study of children with homozygous sickle cell anemia (n = 17) and unaffected children (n = 11). We measured serum and red blood cell folate, vitamin B6, vitamin B12, and homocysteine concentrations, and assessed micronutrient intake. RESULTS: Children with sickle cell anemia had concentrations of homocysteine slightly higher than those of unaffected children. They had lower vitamin B6 concentrations and comparable concentrations of folate and vitamin B12. Homocysteine concentration was inversely related to vitamin B12 concentration and was not independently associated with levels of vitamin B6 or folate. CONCLUSION: Despite comparable intake, children with sickle cell anemia had lower concentrations of vitamin B6 than unaffected children. Larger studies are needed to determine if chronically low serum vitamin B6 concentration contributes to hyperhomocysteinemia in this population. SN - 0038-4348 UR - https://www.unboundmedicine.com/medline/citation/14982264/full_citation L2 - http://dx.doi.org/10.1097/01.SMJ.0000051740.56511.93 DB - PRIME DP - Unbound Medicine ER -