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Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials.
Complement Ther Med. 2003 Dec; 11(4):215-22.CT

Abstract

OBJECTIVE

To investigate the effectiveness of valerian for the management of chronic insomnia in general practice.

DESIGN

Valerian versus placebo in a series of n-of-1 trials, in Queensland, Australia.

RESULTS

Of 42 enrolled patients, 24 (57%) had sufficient data for inclusion into the n-of-1 analysis. Response to valerian was fair for 23 (96%) participants evaluating their "energy level in the previous day" but poor or modest for all 24 (100%) participants' response to "total sleep time" and for 23 (96%) participants' response to "number of night awakenings" and "morning refreshment". As a group, the proportion of treatment successes ranged from 0.35 (95% CI 0.23, 0.47) to 0.55 (95% CI 0.43, 0.67) for the six elicited outcome sleep variables. There was no significant difference in the number (P=0.06), distribution (P=1.00) or severity (P=0.46) of side effects between valerian and placebo treatments.

CONCLUSIONS

Valerian was not shown to be appreciably better than placebo in promoting sleep or sleep-related factors for any individual patient or for all patients as a group.

Authors+Show Affiliations

Herbal Medicines Research and Education Center, University of Sydney, Sydney, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15022653

Citation

Coxeter, P D., et al. "Valerian Does Not Appear to Reduce Symptoms for Patients With Chronic Insomnia in General Practice Using a Series of Randomised N-of-1 Trials." Complementary Therapies in Medicine, vol. 11, no. 4, 2003, pp. 215-22.
Coxeter PD, Schluter PJ, Eastwood HL, et al. Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. Complement Ther Med. 2003;11(4):215-22.
Coxeter, P. D., Schluter, P. J., Eastwood, H. L., Nikles, C. J., & Glasziou, P. P. (2003). Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. Complementary Therapies in Medicine, 11(4), 215-22.
Coxeter PD, et al. Valerian Does Not Appear to Reduce Symptoms for Patients With Chronic Insomnia in General Practice Using a Series of Randomised N-of-1 Trials. Complement Ther Med. 2003;11(4):215-22. PubMed PMID: 15022653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. AU - Coxeter,P D, AU - Schluter,P J, AU - Eastwood,H L, AU - Nikles,C J, AU - Glasziou,P P, PY - 2004/3/17/pubmed PY - 2004/6/21/medline PY - 2004/3/17/entrez SP - 215 EP - 22 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 11 IS - 4 N2 - OBJECTIVE: To investigate the effectiveness of valerian for the management of chronic insomnia in general practice. DESIGN: Valerian versus placebo in a series of n-of-1 trials, in Queensland, Australia. RESULTS: Of 42 enrolled patients, 24 (57%) had sufficient data for inclusion into the n-of-1 analysis. Response to valerian was fair for 23 (96%) participants evaluating their "energy level in the previous day" but poor or modest for all 24 (100%) participants' response to "total sleep time" and for 23 (96%) participants' response to "number of night awakenings" and "morning refreshment". As a group, the proportion of treatment successes ranged from 0.35 (95% CI 0.23, 0.47) to 0.55 (95% CI 0.43, 0.67) for the six elicited outcome sleep variables. There was no significant difference in the number (P=0.06), distribution (P=1.00) or severity (P=0.46) of side effects between valerian and placebo treatments. CONCLUSIONS: Valerian was not shown to be appreciably better than placebo in promoting sleep or sleep-related factors for any individual patient or for all patients as a group. SN - 0965-2299 UR - https://www.unboundmedicine.com/medline/citation/15022653/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(03)00122-5 DB - PRIME DP - Unbound Medicine ER -