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The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer.

Abstract

It is well known that there are various adverse effects during chemotherapy for cancer treatment. A taste disorder is also seen in 35-70% of patients. It has been reported that a zinc deficiency is associated with the development of these alterations in taste sensation. The purpose of this pilot study was to determine whether the zinc including infusion had the effect on taste disorder in patients with lung cancer. Taste disorder was evaluated as the increase in electrical taste thresholds using an electrogustometer. The plasma zinc concentration was also measured. Although there was no significant correlation, the increase in taste thresholds was detected in many patients who had a low zinc concentration even before receiving chemotherapy. Moreover, after 2 weeks of chemotherapy, almost all patients who did not have a zinc containing infusion showed development of taste disorder (5/5, 100% at chorda tympani area; 4/5, 80% at glossopharyngeal area), whereas no development of taste disorder was observed in those patients receiving a zinc containing infusion. These results suggest the possibility that the administration of zinc during chemotherapy could be a useful supportive therapy for preventing taste disorder and to help maintain a better quality of life.

Authors+Show Affiliations

,

Third Dept. of Internal Medicine, Division of Clinical Oncology and Palliative Medicine, Wakayama Medical University, Wakayama-City, Wakayama, Japan. y-toshi@wakayama-med.ac.jp

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Source

MeSH

Aged
Electricity
Humans
Lung Neoplasms
Middle Aged
Pilot Projects
Quality of Life
Taste Disorders
Taste Threshold
Zinc

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15053297

Citation

Yamagata, T, et al. "The Pilot Trial of the Prevention of the Increase in Electrical Taste Thresholds By Zinc Containing Fluid Infusion During Chemotherapy to Treat Primary Lung Cancer." Journal of Experimental & Clinical Cancer Research : CR, vol. 22, no. 4, 2003, pp. 557-63.
Yamagata T, Nakamura Y, Yamagata Y, et al. The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer. J Exp Clin Cancer Res. 2003;22(4):557-63.
Yamagata, T., Nakamura, Y., Yamagata, Y., Nakanishi, M., Matsunaga, K., Nakanishi, H., ... Yukawa, S. (2003). The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer. Journal of Experimental & Clinical Cancer Research : CR, 22(4), pp. 557-63.
Yamagata T, et al. The Pilot Trial of the Prevention of the Increase in Electrical Taste Thresholds By Zinc Containing Fluid Infusion During Chemotherapy to Treat Primary Lung Cancer. J Exp Clin Cancer Res. 2003;22(4):557-63. PubMed PMID: 15053297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pilot trial of the prevention of the increase in electrical taste thresholds by zinc containing fluid infusion during chemotherapy to treat primary lung cancer. AU - Yamagata,T, AU - Nakamura,Y, AU - Yamagata,Y, AU - Nakanishi,M, AU - Matsunaga,K, AU - Nakanishi,H, AU - Nishimoto,T, AU - Minakata,Y, AU - Mune,M, AU - Yukawa,S, PY - 2004/4/1/pubmed PY - 2004/10/1/medline PY - 2004/4/1/entrez SP - 557 EP - 63 JF - Journal of experimental & clinical cancer research : CR JO - J. Exp. Clin. Cancer Res. VL - 22 IS - 4 N2 - It is well known that there are various adverse effects during chemotherapy for cancer treatment. A taste disorder is also seen in 35-70% of patients. It has been reported that a zinc deficiency is associated with the development of these alterations in taste sensation. The purpose of this pilot study was to determine whether the zinc including infusion had the effect on taste disorder in patients with lung cancer. Taste disorder was evaluated as the increase in electrical taste thresholds using an electrogustometer. The plasma zinc concentration was also measured. Although there was no significant correlation, the increase in taste thresholds was detected in many patients who had a low zinc concentration even before receiving chemotherapy. Moreover, after 2 weeks of chemotherapy, almost all patients who did not have a zinc containing infusion showed development of taste disorder (5/5, 100% at chorda tympani area; 4/5, 80% at glossopharyngeal area), whereas no development of taste disorder was observed in those patients receiving a zinc containing infusion. These results suggest the possibility that the administration of zinc during chemotherapy could be a useful supportive therapy for preventing taste disorder and to help maintain a better quality of life. SN - 0392-9078 UR - https://www.unboundmedicine.com/medline/citation/15053297/full_citation L2 - http://www.diseaseinfosearch.org/result/4334 DB - PRIME DP - Unbound Medicine ER -